Copeptin response to hypoglycemic stress is linked to prolactin activation in children
Purpose The physiological role of arginine vasopressin (AVP) in the acute stress response in humans and especially in children is unclear. The aim of this study was to explore the interaction between copeptin, a well-established surrogate marker of AVP release, and anterior pituitary hormone activat...
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| Veröffentlicht in: | Pituitary 2020-12, Vol.23 (6), p.681-690 |
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| creator | Drummond, Juliana B. Soares, Beatriz S. Pedrosa, William Vieira, Erica L. M. Teixeira, Antonio L. Christ-Crain, Mirjam Ribeiro-Oliveira, Antonio |
| description | Purpose
The physiological role of arginine vasopressin (AVP) in the acute stress response in humans and especially in children is unclear. The aim of this study was to explore the interaction between copeptin, a well-established surrogate marker of AVP release, and anterior pituitary hormone activation in response to acute hypoglycemic stress in children and adolescents.
Methods
We conducted an exploratory single center study involving 77 children and adolescents undergoing insulin-induced hypoglycemia. Blood levels of copeptin, ACTH, cortisol, GH, prolactin, interleukin-6 (IL-6), adrenaline and noradrenaline were determined at baseline and after insulin-induced hypoglycemia.
Results
Basal plasma levels of copeptin (median: 5.2 pmol/L) increased significantly after hypoglycemia (median 9.7 pmol/L;
P
|
| doi_str_mv | 10.1007/s11102-020-01076-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2437848694</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2471694359</sourcerecordid><originalsourceid>FETCH-LOGICAL-c352t-e060e0de8fa424c7dd37da27f5d7862c7095cc27835c8e2a88093aac6a3b704b3</originalsourceid><addsrcrecordid>eNp9kEtLAzEUhYMoWKt_wNWAGzfRm8ck6VKKLyi4UXEX0kymTZ1OxmQq9N-bcQTBhZv74H7ncDkInRO4IgDyOhFCgGKggIGAFFgcoAkpJcOSAzvMM1MCM07ejtFJShvIFDA-Qa_z0Lmu920RXepCm1zRh2K978Kq2Vu39bZIfT6lwqei8e27qwagi6ExdpAN9dP0PrRF3uzaN1V07Sk6qk2T3NlPn6KXu9vn-QNePN0_zm8W2LKS9tiBAAeVU7XhlFtZVUxWhsq6rKQS1EqYldZSqVhplaNGKZgxY6wwbCmBL9kUXY6--aGPnUu93vpkXdOY1oVd0pQzqbgSM57Riz_oJuxim7_LlCQDUs4yRUfKxpBSdLXuot-auNcE9BC1HqPWOWr9HbUWWcRGUcpwu3Lx1_of1RedEoHN</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2471694359</pqid></control><display><type>article</type><title>Copeptin response to hypoglycemic stress is linked to prolactin activation in children</title><source>SpringerLink Journals - AutoHoldings</source><creator>Drummond, Juliana B. ; Soares, Beatriz S. ; Pedrosa, William ; Vieira, Erica L. M. ; Teixeira, Antonio L. ; Christ-Crain, Mirjam ; Ribeiro-Oliveira, Antonio</creator><creatorcontrib>Drummond, Juliana B. ; Soares, Beatriz S. ; Pedrosa, William ; Vieira, Erica L. M. ; Teixeira, Antonio L. ; Christ-Crain, Mirjam ; Ribeiro-Oliveira, Antonio</creatorcontrib><description>Purpose
The physiological role of arginine vasopressin (AVP) in the acute stress response in humans and especially in children is unclear. The aim of this study was to explore the interaction between copeptin, a well-established surrogate marker of AVP release, and anterior pituitary hormone activation in response to acute hypoglycemic stress in children and adolescents.
Methods
We conducted an exploratory single center study involving 77 children and adolescents undergoing insulin-induced hypoglycemia. Blood levels of copeptin, ACTH, cortisol, GH, prolactin, interleukin-6 (IL-6), adrenaline and noradrenaline were determined at baseline and after insulin-induced hypoglycemia.
Results
Basal plasma levels of copeptin (median: 5.2 pmol/L) increased significantly after hypoglycemia (median 9.7 pmol/L;
P
< 0.0001). Subjects with insufficient HPA axis response or severe GH deficiency had lower hypoglycemia-induced copeptin increase (median: 2.3 pmol/L) compared with individuals with intact pituitary response (median: 5.2 pmol/L,
P
= 0.02). Copeptin increase correlated significantly with the maximal increase of ACTH (r
s
= 0.30;
P
= 0.010), cortisol (r
s
= 0.33;
P
= 0.003), prolactin (r
s
= 0.25;
P
= 0.03), IL-6 (r
s
= 0.35;
P
= 0.008) and with BMI-SDS (r
s
= − 0.28,
P
= 0.01). In multivariate regression analysis, prolactin increase was the only independent variable associated with copeptin increase (
P
= 0.0004).
Conclusion
Our data indicate that: (1) hypoglycemic stress elicits a marked copeptin response in children and adolescents, pointing out its role as an acute stress marker in this population; (2) stress-induced AVP/copeptin release is associated with anterior pituitary activation, mainly a prolactin response.</description><identifier>ISSN: 1386-341X</identifier><identifier>EISSN: 1573-7403</identifier><identifier>DOI: 10.1007/s11102-020-01076-6</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adolescents ; Adrenocorticotropic hormone ; Argipressin ; Blood levels ; Children ; Cortisol ; Endocrinology ; Epinephrine ; Growth hormones ; Human Physiology ; Hypoglycemia ; Hypothalamic-pituitary-adrenal axis ; Insulin ; Interleukin 6 ; Medicine ; Medicine & Public Health ; Norepinephrine ; Pituitary (anterior) ; Pituitary hormones ; Plasma levels ; Prolactin ; Stress response ; Teenagers ; Vasopressin</subject><ispartof>Pituitary, 2020-12, Vol.23 (6), p.681-690</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-e060e0de8fa424c7dd37da27f5d7862c7095cc27835c8e2a88093aac6a3b704b3</citedby><cites>FETCH-LOGICAL-c352t-e060e0de8fa424c7dd37da27f5d7862c7095cc27835c8e2a88093aac6a3b704b3</cites><orcidid>0000-0002-9804-978X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11102-020-01076-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11102-020-01076-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids></links><search><creatorcontrib>Drummond, Juliana B.</creatorcontrib><creatorcontrib>Soares, Beatriz S.</creatorcontrib><creatorcontrib>Pedrosa, William</creatorcontrib><creatorcontrib>Vieira, Erica L. M.</creatorcontrib><creatorcontrib>Teixeira, Antonio L.</creatorcontrib><creatorcontrib>Christ-Crain, Mirjam</creatorcontrib><creatorcontrib>Ribeiro-Oliveira, Antonio</creatorcontrib><title>Copeptin response to hypoglycemic stress is linked to prolactin activation in children</title><title>Pituitary</title><addtitle>Pituitary</addtitle><description>Purpose
The physiological role of arginine vasopressin (AVP) in the acute stress response in humans and especially in children is unclear. The aim of this study was to explore the interaction between copeptin, a well-established surrogate marker of AVP release, and anterior pituitary hormone activation in response to acute hypoglycemic stress in children and adolescents.
Methods
We conducted an exploratory single center study involving 77 children and adolescents undergoing insulin-induced hypoglycemia. Blood levels of copeptin, ACTH, cortisol, GH, prolactin, interleukin-6 (IL-6), adrenaline and noradrenaline were determined at baseline and after insulin-induced hypoglycemia.
Results
Basal plasma levels of copeptin (median: 5.2 pmol/L) increased significantly after hypoglycemia (median 9.7 pmol/L;
P
< 0.0001). Subjects with insufficient HPA axis response or severe GH deficiency had lower hypoglycemia-induced copeptin increase (median: 2.3 pmol/L) compared with individuals with intact pituitary response (median: 5.2 pmol/L,
P
= 0.02). Copeptin increase correlated significantly with the maximal increase of ACTH (r
s
= 0.30;
P
= 0.010), cortisol (r
s
= 0.33;
P
= 0.003), prolactin (r
s
= 0.25;
P
= 0.03), IL-6 (r
s
= 0.35;
P
= 0.008) and with BMI-SDS (r
s
= − 0.28,
P
= 0.01). In multivariate regression analysis, prolactin increase was the only independent variable associated with copeptin increase (
P
= 0.0004).
Conclusion
Our data indicate that: (1) hypoglycemic stress elicits a marked copeptin response in children and adolescents, pointing out its role as an acute stress marker in this population; (2) stress-induced AVP/copeptin release is associated with anterior pituitary activation, mainly a prolactin response.</description><subject>Adolescents</subject><subject>Adrenocorticotropic hormone</subject><subject>Argipressin</subject><subject>Blood levels</subject><subject>Children</subject><subject>Cortisol</subject><subject>Endocrinology</subject><subject>Epinephrine</subject><subject>Growth hormones</subject><subject>Human Physiology</subject><subject>Hypoglycemia</subject><subject>Hypothalamic-pituitary-adrenal axis</subject><subject>Insulin</subject><subject>Interleukin 6</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Norepinephrine</subject><subject>Pituitary (anterior)</subject><subject>Pituitary hormones</subject><subject>Plasma levels</subject><subject>Prolactin</subject><subject>Stress response</subject><subject>Teenagers</subject><subject>Vasopressin</subject><issn>1386-341X</issn><issn>1573-7403</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kEtLAzEUhYMoWKt_wNWAGzfRm8ck6VKKLyi4UXEX0kymTZ1OxmQq9N-bcQTBhZv74H7ncDkInRO4IgDyOhFCgGKggIGAFFgcoAkpJcOSAzvMM1MCM07ejtFJShvIFDA-Qa_z0Lmu920RXepCm1zRh2K978Kq2Vu39bZIfT6lwqei8e27qwagi6ExdpAN9dP0PrRF3uzaN1V07Sk6qk2T3NlPn6KXu9vn-QNePN0_zm8W2LKS9tiBAAeVU7XhlFtZVUxWhsq6rKQS1EqYldZSqVhplaNGKZgxY6wwbCmBL9kUXY6--aGPnUu93vpkXdOY1oVd0pQzqbgSM57Riz_oJuxim7_LlCQDUs4yRUfKxpBSdLXuot-auNcE9BC1HqPWOWr9HbUWWcRGUcpwu3Lx1_of1RedEoHN</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Drummond, Juliana B.</creator><creator>Soares, Beatriz S.</creator><creator>Pedrosa, William</creator><creator>Vieira, Erica L. M.</creator><creator>Teixeira, Antonio L.</creator><creator>Christ-Crain, Mirjam</creator><creator>Ribeiro-Oliveira, Antonio</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9804-978X</orcidid></search><sort><creationdate>20201201</creationdate><title>Copeptin response to hypoglycemic stress is linked to prolactin activation in children</title><author>Drummond, Juliana B. ; Soares, Beatriz S. ; Pedrosa, William ; Vieira, Erica L. M. ; Teixeira, Antonio L. ; Christ-Crain, Mirjam ; Ribeiro-Oliveira, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-e060e0de8fa424c7dd37da27f5d7862c7095cc27835c8e2a88093aac6a3b704b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescents</topic><topic>Adrenocorticotropic hormone</topic><topic>Argipressin</topic><topic>Blood levels</topic><topic>Children</topic><topic>Cortisol</topic><topic>Endocrinology</topic><topic>Epinephrine</topic><topic>Growth hormones</topic><topic>Human Physiology</topic><topic>Hypoglycemia</topic><topic>Hypothalamic-pituitary-adrenal axis</topic><topic>Insulin</topic><topic>Interleukin 6</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Norepinephrine</topic><topic>Pituitary (anterior)</topic><topic>Pituitary hormones</topic><topic>Plasma levels</topic><topic>Prolactin</topic><topic>Stress response</topic><topic>Teenagers</topic><topic>Vasopressin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drummond, Juliana B.</creatorcontrib><creatorcontrib>Soares, Beatriz S.</creatorcontrib><creatorcontrib>Pedrosa, William</creatorcontrib><creatorcontrib>Vieira, Erica L. M.</creatorcontrib><creatorcontrib>Teixeira, Antonio L.</creatorcontrib><creatorcontrib>Christ-Crain, Mirjam</creatorcontrib><creatorcontrib>Ribeiro-Oliveira, Antonio</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pituitary</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drummond, Juliana B.</au><au>Soares, Beatriz S.</au><au>Pedrosa, William</au><au>Vieira, Erica L. M.</au><au>Teixeira, Antonio L.</au><au>Christ-Crain, Mirjam</au><au>Ribeiro-Oliveira, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Copeptin response to hypoglycemic stress is linked to prolactin activation in children</atitle><jtitle>Pituitary</jtitle><stitle>Pituitary</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>23</volume><issue>6</issue><spage>681</spage><epage>690</epage><pages>681-690</pages><issn>1386-341X</issn><eissn>1573-7403</eissn><abstract>Purpose
The physiological role of arginine vasopressin (AVP) in the acute stress response in humans and especially in children is unclear. The aim of this study was to explore the interaction between copeptin, a well-established surrogate marker of AVP release, and anterior pituitary hormone activation in response to acute hypoglycemic stress in children and adolescents.
Methods
We conducted an exploratory single center study involving 77 children and adolescents undergoing insulin-induced hypoglycemia. Blood levels of copeptin, ACTH, cortisol, GH, prolactin, interleukin-6 (IL-6), adrenaline and noradrenaline were determined at baseline and after insulin-induced hypoglycemia.
Results
Basal plasma levels of copeptin (median: 5.2 pmol/L) increased significantly after hypoglycemia (median 9.7 pmol/L;
P
< 0.0001). Subjects with insufficient HPA axis response or severe GH deficiency had lower hypoglycemia-induced copeptin increase (median: 2.3 pmol/L) compared with individuals with intact pituitary response (median: 5.2 pmol/L,
P
= 0.02). Copeptin increase correlated significantly with the maximal increase of ACTH (r
s
= 0.30;
P
= 0.010), cortisol (r
s
= 0.33;
P
= 0.003), prolactin (r
s
= 0.25;
P
= 0.03), IL-6 (r
s
= 0.35;
P
= 0.008) and with BMI-SDS (r
s
= − 0.28,
P
= 0.01). In multivariate regression analysis, prolactin increase was the only independent variable associated with copeptin increase (
P
= 0.0004).
Conclusion
Our data indicate that: (1) hypoglycemic stress elicits a marked copeptin response in children and adolescents, pointing out its role as an acute stress marker in this population; (2) stress-induced AVP/copeptin release is associated with anterior pituitary activation, mainly a prolactin response.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11102-020-01076-6</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-9804-978X</orcidid></addata></record> |
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| ispartof | Pituitary, 2020-12, Vol.23 (6), p.681-690 |
| issn | 1386-341X 1573-7403 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Adolescents Adrenocorticotropic hormone Argipressin Blood levels Children Cortisol Endocrinology Epinephrine Growth hormones Human Physiology Hypoglycemia Hypothalamic-pituitary-adrenal axis Insulin Interleukin 6 Medicine Medicine & Public Health Norepinephrine Pituitary (anterior) Pituitary hormones Plasma levels Prolactin Stress response Teenagers Vasopressin |
| title | Copeptin response to hypoglycemic stress is linked to prolactin activation in children |
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