The Action of Benzene, Resveratrol and Their Combination on Ovarian Cell Hormone Release
The aim of our study was to examine the direct influence of plant polyphenol resveratrol and oil-related environmental contaminant benzene on ovarian hormone release, as well as the ability of resveratrol to prevent the effect of benzene. Porcine ovarian granulosa cells were cultured with and withou...
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| Veröffentlicht in: | Folia biologica 2020-01, Vol.66 (2), p.67-71 |
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| container_title | Folia biologica |
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| creator | Sirotkin, A Kádasi, A Balaží, A Kotwica, J Alwasel, S Harrath, A H |
| description | The aim of our study was to examine the direct influence of plant polyphenol resveratrol and oil-related environmental contaminant benzene on ovarian hormone release, as well as the ability of resveratrol to prevent the effect of benzene. Porcine ovarian granulosa cells were cultured with and without resveratrol (0, 1,10 or 100 ug/ml) alone or in combination with 0.1% benzene. The release of progesterone, oxytocin and prostaglandin F was measured by enzyme immunoassay (EIA). Benzene promoted the release of progesterone, oxytocin and prostaglandin F. Resveratrol, when given alone, stimulated both progesterone and prostaglandin F, but not the oxytocin output. Moreover, resveratrol prevented and even inverted the stimulatory action of benzene on all analysed hormones. These observations demonstrate the direct influence of both benzene and resveratrol on porcine ovarian hormone release, as well as the ability of resveratrol to prevent the benzene action on the ovary. |
| doi_str_mv | 10.14712/fb2020066020067 |
| format | Article |
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Porcine ovarian granulosa cells were cultured with and without resveratrol (0, 1,10 or 100 ug/ml) alone or in combination with 0.1% benzene. The release of progesterone, oxytocin and prostaglandin F was measured by enzyme immunoassay (EIA). Benzene promoted the release of progesterone, oxytocin and prostaglandin F. Resveratrol, when given alone, stimulated both progesterone and prostaglandin F, but not the oxytocin output. Moreover, resveratrol prevented and even inverted the stimulatory action of benzene on all analysed hormones. 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Porcine ovarian granulosa cells were cultured with and without resveratrol (0, 1,10 or 100 ug/ml) alone or in combination with 0.1% benzene. The release of progesterone, oxytocin and prostaglandin F was measured by enzyme immunoassay (EIA). Benzene promoted the release of progesterone, oxytocin and prostaglandin F. Resveratrol, when given alone, stimulated both progesterone and prostaglandin F, but not the oxytocin output. Moreover, resveratrol prevented and even inverted the stimulatory action of benzene on all analysed hormones. These observations demonstrate the direct influence of both benzene and resveratrol on porcine ovarian hormone release, as well as the ability of resveratrol to prevent the benzene action on the ovary.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Benzene</subject><subject>Benzene - pharmacology</subject><subject>Cell growth</subject><subject>Cells, Cultured</subject><subject>Contaminants</subject><subject>Enzyme immunoassay</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Female</subject><subject>Fertility</subject><subject>Granulosa cells</subject><subject>Granulosa Cells - cytology</subject><subject>Granulosa Cells - drug effects</subject><subject>Granulosa Cells - metabolism</subject><subject>Hormone release</subject><subject>Hormones</subject><subject>Hydrocarbons</subject><subject>Immunoassay</subject><subject>Ovaries</subject><subject>Oxytocin</subject><subject>Oxytocin - metabolism</subject><subject>Progesterone</subject><subject>Progesterone - metabolism</subject><subject>Prostaglandins</subject><subject>Prostaglandins F - metabolism</subject><subject>Resveratrol</subject><subject>Resveratrol - pharmacology</subject><subject>Swine</subject><subject>Variance analysis</subject><issn>0015-5500</issn><issn>2533-7602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkM1LAzEQxYMotlbvniTgxYOr2Xzsx7EuaoVCQSp4W7KbCW7ZTWqyW9C_3thWD73MMMzvPR4PocuY3MU8jem9riihhCTJdqZHaEwFY1Ea7mM0JiQWkRCEjNCZ9ytCGCeMnaIRo5mIM5aM0fvyA_C07htrsNX4Acw3GLjFr-A34GTvbIulUThgjcOF7arGyB1t8GIjXSMNLqBt8cy6zhoIyhakh3N0omXr4WK_J-jt6XFZzKL54vmlmM6jmuZ5H1WEc00zWuUqlVmag64ZUTHNQdSyZorrlNcC8ioVSnOhMp38vnmmlYYsr9gE3ex8185-DuD7smt8HQJJA3bwJeUszXiYPKDXB-jKDs6EdIGiTCRc5CRQZEfVznrvQJdr13TSfZUxKbetlwetB8nV3nioOlD_gr-a2Q-kPnvf</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Sirotkin, A</creator><creator>Kádasi, A</creator><creator>Balaží, A</creator><creator>Kotwica, J</creator><creator>Alwasel, S</creator><creator>Harrath, A H</creator><general>Charles University in Prague, First Faculty of Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200101</creationdate><title>The Action of Benzene, Resveratrol and Their Combination on Ovarian Cell Hormone Release</title><author>Sirotkin, A ; Kádasi, A ; Balaží, A ; Kotwica, J ; Alwasel, S ; Harrath, A H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c299t-b044f282b9d7a879efc30d129e5cac3d4f74c5e9b75df45d8f60d1248fdfe89b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Benzene</topic><topic>Benzene - pharmacology</topic><topic>Cell growth</topic><topic>Cells, Cultured</topic><topic>Contaminants</topic><topic>Enzyme immunoassay</topic><topic>Enzymes</topic><topic>Experiments</topic><topic>Female</topic><topic>Fertility</topic><topic>Granulosa cells</topic><topic>Granulosa Cells - cytology</topic><topic>Granulosa Cells - drug effects</topic><topic>Granulosa Cells - metabolism</topic><topic>Hormone release</topic><topic>Hormones</topic><topic>Hydrocarbons</topic><topic>Immunoassay</topic><topic>Ovaries</topic><topic>Oxytocin</topic><topic>Oxytocin - metabolism</topic><topic>Progesterone</topic><topic>Progesterone - metabolism</topic><topic>Prostaglandins</topic><topic>Prostaglandins F - metabolism</topic><topic>Resveratrol</topic><topic>Resveratrol - pharmacology</topic><topic>Swine</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sirotkin, A</creatorcontrib><creatorcontrib>Kádasi, A</creatorcontrib><creatorcontrib>Balaží, A</creatorcontrib><creatorcontrib>Kotwica, J</creatorcontrib><creatorcontrib>Alwasel, S</creatorcontrib><creatorcontrib>Harrath, A H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Folia biologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sirotkin, A</au><au>Kádasi, A</au><au>Balaží, A</au><au>Kotwica, J</au><au>Alwasel, S</au><au>Harrath, A H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Action of Benzene, Resveratrol and Their Combination on Ovarian Cell Hormone Release</atitle><jtitle>Folia biologica</jtitle><addtitle>Folia Biol (Praha)</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>66</volume><issue>2</issue><spage>67</spage><epage>71</epage><pages>67-71</pages><issn>0015-5500</issn><eissn>2533-7602</eissn><abstract>The aim of our study was to examine the direct influence of plant polyphenol resveratrol and oil-related environmental contaminant benzene on ovarian hormone release, as well as the ability of resveratrol to prevent the effect of benzene. Porcine ovarian granulosa cells were cultured with and without resveratrol (0, 1,10 or 100 ug/ml) alone or in combination with 0.1% benzene. The release of progesterone, oxytocin and prostaglandin F was measured by enzyme immunoassay (EIA). Benzene promoted the release of progesterone, oxytocin and prostaglandin F. Resveratrol, when given alone, stimulated both progesterone and prostaglandin F, but not the oxytocin output. Moreover, resveratrol prevented and even inverted the stimulatory action of benzene on all analysed hormones. These observations demonstrate the direct influence of both benzene and resveratrol on porcine ovarian hormone release, as well as the ability of resveratrol to prevent the benzene action on the ovary.</abstract><cop>Czech Republic</cop><pub>Charles University in Prague, First Faculty of Medicine</pub><pmid>32851836</pmid><doi>10.14712/fb2020066020067</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Apoptosis Benzene Benzene - pharmacology Cell growth Cells, Cultured Contaminants Enzyme immunoassay Enzymes Experiments Female Fertility Granulosa cells Granulosa Cells - cytology Granulosa Cells - drug effects Granulosa Cells - metabolism Hormone release Hormones Hydrocarbons Immunoassay Ovaries Oxytocin Oxytocin - metabolism Progesterone Progesterone - metabolism Prostaglandins Prostaglandins F - metabolism Resveratrol Resveratrol - pharmacology Swine Variance analysis |
| title | The Action of Benzene, Resveratrol and Their Combination on Ovarian Cell Hormone Release |
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