Guidelines for β‑Lactam Synthesis: Glycal Protecting Groups Dictate Stereoelectronics and [2+2] Cycloaddition Kinetics

The alkene-isocyanate cycloaddition method affords β-lactams from glycals with high regio- and stereoselectivity, but the factors that determine substrate reactivity are poorly understood. Thus, we synthesized a library of 17 electron-rich alkenes (glycals) with varied protecting groups to systemati...

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Veröffentlicht in:	Journal of organic chemistry 2020-10, Vol.85 (19), p.12044-12057
Hauptverfasser:	Balijepalli, Anant S, McNeely, James H, Hamoud, Aladin, Grinstaff, Mark W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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