Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis
Background and purpose Benign paroxysmal positional vertigo is one of the most common vestibular diseases, especially in the elderly. Although the treatment of BPPV is relatively successful, many patients suffer recurrence after treatment. Therefore, identifying potential risk factors for BPPV recur...
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| Veröffentlicht in: | Journal of neurology 2021-11, Vol.268 (11), p.4117-4127 |
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| creator | Chen, Jinbao Zhang, Senlin Cui, Kai Liu, Chuxuan |
| description | Background and purpose
Benign paroxysmal positional vertigo is one of the most common vestibular diseases, especially in the elderly. Although the treatment of BPPV is relatively successful, many patients suffer recurrence after treatment. Therefore, identifying potential risk factors for BPPV recurrence may help improve treatment outcome and patient prognosis. However, some related risk factors for BPPV recurrence are relatively controversial and poorly studied. This meta-analysis aims to identify potential risk factors associated with BPPV recurrence, thereby reducing the recurrence rate of BPPV and improving the prognosis of patients.
Methods
This meta-analysis was conducted through systematically searching PubMed, Embase, and the Cochrane Library for eligible English original studies published up to June 2020. All search results were reviewed based on our inclusion and exclusion criteria. We calculated the pooled odds ratios (ORs) or the mean differences (MDs) with their corresponding 95% confidence intervals (CIs) to evaluate the effects of included risk factors on BPPV recurrence.
Results
A total of 14 studies involving 3060 BPPV patients published between 2010 and 2019 were finally included, including six prospective studies and eight retrospective studies, with a NOS score ranged from 6 to 9. Our pooled results of this meta-analysis suggested that the recurrence of BPPV was closely related to female gender (OR = 1.42; 95% CI 1.17–1.74;
P
= 0.0004), hypertension (OR = 2.61; 95% CI 1.22–5.59;
P
= 0.01), diabetes mellitus (OR = 2.62; 95% CI 1.25–5.48;
P
= 0.01), hyperlipidemia (OR = 1.60; 95% CI 1.23–2.09;
P
= 0.0006), osteoporosis (OR = 1.72; 95% CI 1.03–2.88;
P
= 0.04) and vitamin D deficiency (MD = − 3.29; 95% CI − 5.32 to − 1.26;
P
= 0.001).
Conclusion
This meta-analysis indicated that female gender, hypertension, diabetes mellitus, hyperlipidemia, osteoporosis, and vitamin D deficiency were risk factors for BPPV recurrence. However, the effects of other potential risk factors including advanced age, migraine, head trauma, and Menière’s disease on BPPV recurrence need further investigations. Furthermore, most studies included in this meta-analysis were performed in Asia, so our results cannot easily be extended to the whole world population. Therefore, more large-scale prospective studies in different countries are required to further investigate these risk factors. |
| doi_str_mv | 10.1007/s00415-020-10175-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2437121592</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580827859</sourcerecordid><originalsourceid>FETCH-LOGICAL-c418t-86637ddb9f243b9b6fe53f446ac45781906c98a36e4a9151b6c9276c3fa95d3b3</originalsourceid><addsrcrecordid>eNp9kE9LxDAQxYMouK5-AU8BL16qkyZpG2-y-A8WBNFzSNO0ZN02a6a7ut_e6AqCB08zw_u9x_AIOWVwwQDKSwQQTGaQQ8aAlWnbIxMmeJ4xIdU-mQAXkEkuxSE5QlwAQJWECemePL7S1tgxRKRtiLR2g-8GujIxfGyxN0u6CuhHH4a0blwcfRdodHYdoxusu6KG4hZH15vR2yRsvHunZmho70aTmeTaosdjctCaJbqTnzklL7c3z7P7bP549zC7nmdWsGrMqqLgZdPUqs0Fr1VdtE7yVojCWCHLiikorKoML5wwiklWpzMvC8tbo2TDaz4l57vcVQxva4ej7j1at1yawYU16hRbspxJlSf07A-6COuY_k2UrKDKy0qqROU7ysaAGF2rV9H3Jm41A_3Vvd51r1P3-rt7DcnEdyZM8NC5-Bv9j-sTnCaHrw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580827859</pqid></control><display><type>article</type><title>Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis</title><source>SpringerLink Journals - AutoHoldings</source><creator>Chen, Jinbao ; Zhang, Senlin ; Cui, Kai ; Liu, Chuxuan</creator><creatorcontrib>Chen, Jinbao ; Zhang, Senlin ; Cui, Kai ; Liu, Chuxuan</creatorcontrib><description>Background and purpose
Benign paroxysmal positional vertigo is one of the most common vestibular diseases, especially in the elderly. Although the treatment of BPPV is relatively successful, many patients suffer recurrence after treatment. Therefore, identifying potential risk factors for BPPV recurrence may help improve treatment outcome and patient prognosis. However, some related risk factors for BPPV recurrence are relatively controversial and poorly studied. This meta-analysis aims to identify potential risk factors associated with BPPV recurrence, thereby reducing the recurrence rate of BPPV and improving the prognosis of patients.
Methods
This meta-analysis was conducted through systematically searching PubMed, Embase, and the Cochrane Library for eligible English original studies published up to June 2020. All search results were reviewed based on our inclusion and exclusion criteria. We calculated the pooled odds ratios (ORs) or the mean differences (MDs) with their corresponding 95% confidence intervals (CIs) to evaluate the effects of included risk factors on BPPV recurrence.
Results
A total of 14 studies involving 3060 BPPV patients published between 2010 and 2019 were finally included, including six prospective studies and eight retrospective studies, with a NOS score ranged from 6 to 9. Our pooled results of this meta-analysis suggested that the recurrence of BPPV was closely related to female gender (OR = 1.42; 95% CI 1.17–1.74;
P
= 0.0004), hypertension (OR = 2.61; 95% CI 1.22–5.59;
P
= 0.01), diabetes mellitus (OR = 2.62; 95% CI 1.25–5.48;
P
= 0.01), hyperlipidemia (OR = 1.60; 95% CI 1.23–2.09;
P
= 0.0006), osteoporosis (OR = 1.72; 95% CI 1.03–2.88;
P
= 0.04) and vitamin D deficiency (MD = − 3.29; 95% CI − 5.32 to − 1.26;
P
= 0.001).
Conclusion
This meta-analysis indicated that female gender, hypertension, diabetes mellitus, hyperlipidemia, osteoporosis, and vitamin D deficiency were risk factors for BPPV recurrence. However, the effects of other potential risk factors including advanced age, migraine, head trauma, and Menière’s disease on BPPV recurrence need further investigations. Furthermore, most studies included in this meta-analysis were performed in Asia, so our results cannot easily be extended to the whole world population. Therefore, more large-scale prospective studies in different countries are required to further investigate these risk factors.</description><identifier>ISSN: 0340-5354</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-020-10175-0</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Diabetes ; Diabetes mellitus ; Gender ; Headache ; Hyperlipidemia ; Hypertension ; Medicine ; Medicine & Public Health ; Meniere's disease ; Meta-analysis ; Migraine ; Neurology ; Neuroradiology ; Neurosciences ; Osteoporosis ; Patients ; Prognosis ; Review ; Risk factors ; Trauma ; Vertigo ; Vestibular system ; Vitamin D ; Vitamin deficiency</subject><ispartof>Journal of neurology, 2021-11, Vol.268 (11), p.4117-4127</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-86637ddb9f243b9b6fe53f446ac45781906c98a36e4a9151b6c9276c3fa95d3b3</citedby><cites>FETCH-LOGICAL-c418t-86637ddb9f243b9b6fe53f446ac45781906c98a36e4a9151b6c9276c3fa95d3b3</cites><orcidid>0000-0002-1226-1457</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-020-10175-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-020-10175-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Chen, Jinbao</creatorcontrib><creatorcontrib>Zhang, Senlin</creatorcontrib><creatorcontrib>Cui, Kai</creatorcontrib><creatorcontrib>Liu, Chuxuan</creatorcontrib><title>Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><description>Background and purpose
Benign paroxysmal positional vertigo is one of the most common vestibular diseases, especially in the elderly. Although the treatment of BPPV is relatively successful, many patients suffer recurrence after treatment. Therefore, identifying potential risk factors for BPPV recurrence may help improve treatment outcome and patient prognosis. However, some related risk factors for BPPV recurrence are relatively controversial and poorly studied. This meta-analysis aims to identify potential risk factors associated with BPPV recurrence, thereby reducing the recurrence rate of BPPV and improving the prognosis of patients.
Methods
This meta-analysis was conducted through systematically searching PubMed, Embase, and the Cochrane Library for eligible English original studies published up to June 2020. All search results were reviewed based on our inclusion and exclusion criteria. We calculated the pooled odds ratios (ORs) or the mean differences (MDs) with their corresponding 95% confidence intervals (CIs) to evaluate the effects of included risk factors on BPPV recurrence.
Results
A total of 14 studies involving 3060 BPPV patients published between 2010 and 2019 were finally included, including six prospective studies and eight retrospective studies, with a NOS score ranged from 6 to 9. Our pooled results of this meta-analysis suggested that the recurrence of BPPV was closely related to female gender (OR = 1.42; 95% CI 1.17–1.74;
P
= 0.0004), hypertension (OR = 2.61; 95% CI 1.22–5.59;
P
= 0.01), diabetes mellitus (OR = 2.62; 95% CI 1.25–5.48;
P
= 0.01), hyperlipidemia (OR = 1.60; 95% CI 1.23–2.09;
P
= 0.0006), osteoporosis (OR = 1.72; 95% CI 1.03–2.88;
P
= 0.04) and vitamin D deficiency (MD = − 3.29; 95% CI − 5.32 to − 1.26;
P
= 0.001).
Conclusion
This meta-analysis indicated that female gender, hypertension, diabetes mellitus, hyperlipidemia, osteoporosis, and vitamin D deficiency were risk factors for BPPV recurrence. However, the effects of other potential risk factors including advanced age, migraine, head trauma, and Menière’s disease on BPPV recurrence need further investigations. Furthermore, most studies included in this meta-analysis were performed in Asia, so our results cannot easily be extended to the whole world population. Therefore, more large-scale prospective studies in different countries are required to further investigate these risk factors.</description><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Gender</subject><subject>Headache</subject><subject>Hyperlipidemia</subject><subject>Hypertension</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Meniere's disease</subject><subject>Meta-analysis</subject><subject>Migraine</subject><subject>Neurology</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Osteoporosis</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Review</subject><subject>Risk factors</subject><subject>Trauma</subject><subject>Vertigo</subject><subject>Vestibular system</subject><subject>Vitamin D</subject><subject>Vitamin deficiency</subject><issn>0340-5354</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kE9LxDAQxYMouK5-AU8BL16qkyZpG2-y-A8WBNFzSNO0ZN02a6a7ut_e6AqCB08zw_u9x_AIOWVwwQDKSwQQTGaQQ8aAlWnbIxMmeJ4xIdU-mQAXkEkuxSE5QlwAQJWECemePL7S1tgxRKRtiLR2g-8GujIxfGyxN0u6CuhHH4a0blwcfRdodHYdoxusu6KG4hZH15vR2yRsvHunZmho70aTmeTaosdjctCaJbqTnzklL7c3z7P7bP549zC7nmdWsGrMqqLgZdPUqs0Fr1VdtE7yVojCWCHLiikorKoML5wwiklWpzMvC8tbo2TDaz4l57vcVQxva4ej7j1at1yawYU16hRbspxJlSf07A-6COuY_k2UrKDKy0qqROU7ysaAGF2rV9H3Jm41A_3Vvd51r1P3-rt7DcnEdyZM8NC5-Bv9j-sTnCaHrw</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>Chen, Jinbao</creator><creator>Zhang, Senlin</creator><creator>Cui, Kai</creator><creator>Liu, Chuxuan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1226-1457</orcidid></search><sort><creationdate>20211101</creationdate><title>Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis</title><author>Chen, Jinbao ; Zhang, Senlin ; Cui, Kai ; Liu, Chuxuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-86637ddb9f243b9b6fe53f446ac45781906c98a36e4a9151b6c9276c3fa95d3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Gender</topic><topic>Headache</topic><topic>Hyperlipidemia</topic><topic>Hypertension</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Meniere's disease</topic><topic>Meta-analysis</topic><topic>Migraine</topic><topic>Neurology</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Osteoporosis</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Review</topic><topic>Risk factors</topic><topic>Trauma</topic><topic>Vertigo</topic><topic>Vestibular system</topic><topic>Vitamin D</topic><topic>Vitamin deficiency</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jinbao</creatorcontrib><creatorcontrib>Zhang, Senlin</creatorcontrib><creatorcontrib>Cui, Kai</creatorcontrib><creatorcontrib>Liu, Chuxuan</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jinbao</au><au>Zhang, Senlin</au><au>Cui, Kai</au><au>Liu, Chuxuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><date>2021-11-01</date><risdate>2021</risdate><volume>268</volume><issue>11</issue><spage>4117</spage><epage>4127</epage><pages>4117-4127</pages><issn>0340-5354</issn><eissn>1432-1459</eissn><abstract>Background and purpose
Benign paroxysmal positional vertigo is one of the most common vestibular diseases, especially in the elderly. Although the treatment of BPPV is relatively successful, many patients suffer recurrence after treatment. Therefore, identifying potential risk factors for BPPV recurrence may help improve treatment outcome and patient prognosis. However, some related risk factors for BPPV recurrence are relatively controversial and poorly studied. This meta-analysis aims to identify potential risk factors associated with BPPV recurrence, thereby reducing the recurrence rate of BPPV and improving the prognosis of patients.
Methods
This meta-analysis was conducted through systematically searching PubMed, Embase, and the Cochrane Library for eligible English original studies published up to June 2020. All search results were reviewed based on our inclusion and exclusion criteria. We calculated the pooled odds ratios (ORs) or the mean differences (MDs) with their corresponding 95% confidence intervals (CIs) to evaluate the effects of included risk factors on BPPV recurrence.
Results
A total of 14 studies involving 3060 BPPV patients published between 2010 and 2019 were finally included, including six prospective studies and eight retrospective studies, with a NOS score ranged from 6 to 9. Our pooled results of this meta-analysis suggested that the recurrence of BPPV was closely related to female gender (OR = 1.42; 95% CI 1.17–1.74;
P
= 0.0004), hypertension (OR = 2.61; 95% CI 1.22–5.59;
P
= 0.01), diabetes mellitus (OR = 2.62; 95% CI 1.25–5.48;
P
= 0.01), hyperlipidemia (OR = 1.60; 95% CI 1.23–2.09;
P
= 0.0006), osteoporosis (OR = 1.72; 95% CI 1.03–2.88;
P
= 0.04) and vitamin D deficiency (MD = − 3.29; 95% CI − 5.32 to − 1.26;
P
= 0.001).
Conclusion
This meta-analysis indicated that female gender, hypertension, diabetes mellitus, hyperlipidemia, osteoporosis, and vitamin D deficiency were risk factors for BPPV recurrence. However, the effects of other potential risk factors including advanced age, migraine, head trauma, and Menière’s disease on BPPV recurrence need further investigations. Furthermore, most studies included in this meta-analysis were performed in Asia, so our results cannot easily be extended to the whole world population. Therefore, more large-scale prospective studies in different countries are required to further investigate these risk factors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00415-020-10175-0</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-1226-1457</orcidid></addata></record> |
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| subjects | Diabetes Diabetes mellitus Gender Headache Hyperlipidemia Hypertension Medicine Medicine & Public Health Meniere's disease Meta-analysis Migraine Neurology Neuroradiology Neurosciences Osteoporosis Patients Prognosis Review Risk factors Trauma Vertigo Vestibular system Vitamin D Vitamin deficiency |
| title | Risk factors for benign paroxysmal positional vertigo recurrence: a systematic review and meta-analysis |
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