Bacterial hepatocyte growth factor receptor agonist stimulates hepatocyte proliferation and accelerates liver regeneration in a partial hepatectomy rat model

Hepatocyte growth factor (HGF) is central to liver regeneration. The Internalin B (InlB) protein is a virulence factor produced by the pathogenic bacterium Listeria monocytogenes. InlB is known to mimic HGF activity by interacting with the HGF receptor (HGFR) and activating HGFR‐controlled signaling...

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Veröffentlicht in:	Drug development research 2021-02, Vol.82 (1), p.123-132
Hauptverfasser:	Kalinin, Egor V., Chalenko, Yaroslava M., Sysolyatina, Elena V., Midiber, Konstantin Y., Gusarov, Alexey M., Kechko, Olga I., Kulikova, Alexandra A., Mikhaleva, Ludmila M., Mukhachev, Andrey Ya, Stanishevskyi, Yaroslav M., Mitkevich, Vladimir A., Sobyanin, Konstantin A., Ermolaeva, Svetlana A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Bacterial Proteins - genetics Bacterial Proteins - pharmacology bacterial toxin Cell proliferation Cell Proliferation - drug effects Diameters Growth factors Hep G2 Cells Hepatectomy Hepatocyte growth factor Hepatocytes Humans InlB Internalin Listeria Listeria monocytogenes Liver liver regeneration Liver Regeneration - drug effects Male Mathematical models Parameters Phosphorylation Proto-Oncogene Proteins c-met - agonists Proto-Oncogene Proteins c-met - genetics Rats Rats, Wistar Receptors Recombinant Proteins - pharmacology Regeneration Rodents Surgery Thermophoresis Virulence Virulence factors Western blotting
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