Lifelong Clinical Impact of the Presence of Sarcomere Gene Mutation in Japanese Patients With Hypertrophic Cardiomyopathy

Background:Hypertrophic cardiomyopathy (HCM) is mainly caused by mutations in sarcomere genes. Regarding the clinical implications of genetic information, little is known about the lifelong clinical effect of sarcomere mutations in Japanese HCM patients.Methods and Results:We studied 211 consecutive...

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Veröffentlicht in:	Circulation Journal 2020/09/25, Vol.84(10), pp.1846-1853
Hauptverfasser:	Nakashima, Yasuteru, Kubo, Toru, Sugiura, Kenta, Ochi, Yuri, Takahashi, Asa, Baba, Yuichi, Hirota, Takayoshi, Yamasaki, Naohito, Kimura, Akinori, Doi, Yoshinori L., Kitaoka, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Adolescent Adult Aged Aged, 80 and over Cardiac Myosins - genetics Cardiomyopathy, Hypertrophic - epidemiology Cardiomyopathy, Hypertrophic - genetics Carrier Proteins - genetics Child Female Genetic Testing - methods Humans Hypertrophic cardiomyopathy Japan - epidemiology Male Middle Aged Mutation Myosin Heavy Chains - genetics Prognosis Retrospective Studies Sarcomere mutations Sarcomeres - genetics Sequence Analysis, DNA - methods Tropomyosin - genetics Troponin I - genetics Troponin T - genetics Young Adult
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