Preoperative neutrophil–lymphocyte ratio, an independent risk factor for postoperative cognitive dysfunction in elderly patients with gastric cancer
Aim This study aimed to investigate the potential risk factors for postoperative cognitive dysfunction (POCD) in elderly patients with gastric cancer (GC) after radical gastrectomy. Methods In total, 221 elderly patients with GC who were scheduled to undergo selective radical gastrectomy in our hosp...
Gespeichert in:
| Veröffentlicht in: | Geriatrics & gerontology international 2020-10, Vol.20 (10), p.927-931 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 931 |
|---|---|
| container_issue | 10 |
| container_start_page | 927 |
| container_title | Geriatrics & gerontology international |
| container_volume | 20 |
| creator | Yong, Rong Meng, Yongsheng |
| description | Aim
This study aimed to investigate the potential risk factors for postoperative cognitive dysfunction (POCD) in elderly patients with gastric cancer (GC) after radical gastrectomy.
Methods
In total, 221 elderly patients with GC who were scheduled to undergo selective radical gastrectomy in our hospital were enrolled in this study. To define early POCD, the neuropsychological assessment was carried out 1 day before surgery and 7 days after surgery. Receiver operating characteristic curve analysis was carried out to evaluate the predicative and cut‐off values of risk factors, including neutrophil–lymphocyte ratio (NLR) for early POCD. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for early POCD.
Results
Of the 221 enrolled elderly patients with GC, 42 were identified as early POCD with an incidence of 19.0% (42 of 221). Receiver operating characteristic curve analysis indicated that NLR was a significant predictor for POCD with a cut‐off value of 2.50 and an area under the curve of 0.711 (95% confidence interval: 0.624–0.798, P |
| doi_str_mv | 10.1111/ggi.14016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2436870669</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2447630823</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3546-b02d88d9ea32dae62ebfe7e91aace6e32e3438ce06bee8cdf92d0f091e24d12a3</originalsourceid><addsrcrecordid>eNp1kdtKxDAQhosoeLzwDQLeKFjNadP2UkRXQdALvS7ZZLob7SY1SV165zsIPqBPYnZXEAQH5gDzzc_An2WHBJ-RFOfTqTkjHBOxke0Qzoscjyq-uZp5Tkal2M52Q3jGmBQVITvZ54MH14GX0bwBstBH77qZab_eP9ph3s2cGiKg5dqdImmRsRo6SMVG5E14QY1U0XnUpOxciL9ayk2tWU16CE1vVZJY3iNoNfh2QF3ikkxACxNnaCpD9EYhJa0Cv59tNbINcPDT97Kn66vHy5v87n58e3lxlys24iKfYKrLUlcgGdUSBIVJAwVUREoFAhgFxlmpAIsJQKl0U1GNG1wRoFwTKtledrzW7bx77SHEem6CgraVFlwfasqZKAssRJXQoz_os-u9Td8liheC4ZKyRJ2sKeVdCB6auvNmLv1QE1wvHaqTQ_XKocSer9mFaWH4H6zH49v1xTcpvJif</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2447630823</pqid></control><display><type>article</type><title>Preoperative neutrophil–lymphocyte ratio, an independent risk factor for postoperative cognitive dysfunction in elderly patients with gastric cancer</title><source>Access via Wiley Online Library</source><creator>Yong, Rong ; Meng, Yongsheng</creator><creatorcontrib>Yong, Rong ; Meng, Yongsheng</creatorcontrib><description>Aim
This study aimed to investigate the potential risk factors for postoperative cognitive dysfunction (POCD) in elderly patients with gastric cancer (GC) after radical gastrectomy.
Methods
In total, 221 elderly patients with GC who were scheduled to undergo selective radical gastrectomy in our hospital were enrolled in this study. To define early POCD, the neuropsychological assessment was carried out 1 day before surgery and 7 days after surgery. Receiver operating characteristic curve analysis was carried out to evaluate the predicative and cut‐off values of risk factors, including neutrophil–lymphocyte ratio (NLR) for early POCD. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for early POCD.
Results
Of the 221 enrolled elderly patients with GC, 42 were identified as early POCD with an incidence of 19.0% (42 of 221). Receiver operating characteristic curve analysis indicated that NLR was a significant predictor for POCD with a cut‐off value of 2.50 and an area under the curve of 0.711 (95% confidence interval: 0.624–0.798, P < 0.001). Preoperative NLR (≥2.50) was the only independent risk factor associated with POCD (odds ratio: 2.44, 95% confidence interval: 1.52–3.68, P = 0.013) by the multivariate logistic regression analysis.
Conclusions
Preoperative NLR level was an independent risk factor for POCD in elderly patients with GC undergoing curative resection. Geriatr Gerontol Int 2020; 20: 927–931.</description><identifier>ISSN: 1444-1586</identifier><identifier>EISSN: 1447-0594</identifier><identifier>DOI: 10.1111/ggi.14016</identifier><language>eng</language><publisher>Kyoto, Japan: John Wiley & Sons Australia, Ltd</publisher><subject>Confidence intervals ; Gastric cancer ; Neutrophils ; neutrophil–lymphocyte ratio ; postoperative cognitive dysfunction ; risk factor ; Risk factors</subject><ispartof>Geriatrics & gerontology international, 2020-10, Vol.20 (10), p.927-931</ispartof><rights>2020 Japan Geriatrics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3546-b02d88d9ea32dae62ebfe7e91aace6e32e3438ce06bee8cdf92d0f091e24d12a3</citedby><cites>FETCH-LOGICAL-c3546-b02d88d9ea32dae62ebfe7e91aace6e32e3438ce06bee8cdf92d0f091e24d12a3</cites><orcidid>0000-0001-8063-7682</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fggi.14016$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fggi.14016$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Yong, Rong</creatorcontrib><creatorcontrib>Meng, Yongsheng</creatorcontrib><title>Preoperative neutrophil–lymphocyte ratio, an independent risk factor for postoperative cognitive dysfunction in elderly patients with gastric cancer</title><title>Geriatrics & gerontology international</title><description>Aim
This study aimed to investigate the potential risk factors for postoperative cognitive dysfunction (POCD) in elderly patients with gastric cancer (GC) after radical gastrectomy.
Methods
In total, 221 elderly patients with GC who were scheduled to undergo selective radical gastrectomy in our hospital were enrolled in this study. To define early POCD, the neuropsychological assessment was carried out 1 day before surgery and 7 days after surgery. Receiver operating characteristic curve analysis was carried out to evaluate the predicative and cut‐off values of risk factors, including neutrophil–lymphocyte ratio (NLR) for early POCD. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for early POCD.
Results
Of the 221 enrolled elderly patients with GC, 42 were identified as early POCD with an incidence of 19.0% (42 of 221). Receiver operating characteristic curve analysis indicated that NLR was a significant predictor for POCD with a cut‐off value of 2.50 and an area under the curve of 0.711 (95% confidence interval: 0.624–0.798, P < 0.001). Preoperative NLR (≥2.50) was the only independent risk factor associated with POCD (odds ratio: 2.44, 95% confidence interval: 1.52–3.68, P = 0.013) by the multivariate logistic regression analysis.
Conclusions
Preoperative NLR level was an independent risk factor for POCD in elderly patients with GC undergoing curative resection. Geriatr Gerontol Int 2020; 20: 927–931.</description><subject>Confidence intervals</subject><subject>Gastric cancer</subject><subject>Neutrophils</subject><subject>neutrophil–lymphocyte ratio</subject><subject>postoperative cognitive dysfunction</subject><subject>risk factor</subject><subject>Risk factors</subject><issn>1444-1586</issn><issn>1447-0594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kdtKxDAQhosoeLzwDQLeKFjNadP2UkRXQdALvS7ZZLob7SY1SV165zsIPqBPYnZXEAQH5gDzzc_An2WHBJ-RFOfTqTkjHBOxke0Qzoscjyq-uZp5Tkal2M52Q3jGmBQVITvZ54MH14GX0bwBstBH77qZab_eP9ph3s2cGiKg5dqdImmRsRo6SMVG5E14QY1U0XnUpOxciL9ayk2tWU16CE1vVZJY3iNoNfh2QF3ikkxACxNnaCpD9EYhJa0Cv59tNbINcPDT97Kn66vHy5v87n58e3lxlys24iKfYKrLUlcgGdUSBIVJAwVUREoFAhgFxlmpAIsJQKl0U1GNG1wRoFwTKtledrzW7bx77SHEem6CgraVFlwfasqZKAssRJXQoz_os-u9Td8liheC4ZKyRJ2sKeVdCB6auvNmLv1QE1wvHaqTQ_XKocSer9mFaWH4H6zH49v1xTcpvJif</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Yong, Rong</creator><creator>Meng, Yongsheng</creator><general>John Wiley & Sons Australia, Ltd</general><general>Blackwell Publishing Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8063-7682</orcidid></search><sort><creationdate>202010</creationdate><title>Preoperative neutrophil–lymphocyte ratio, an independent risk factor for postoperative cognitive dysfunction in elderly patients with gastric cancer</title><author>Yong, Rong ; Meng, Yongsheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3546-b02d88d9ea32dae62ebfe7e91aace6e32e3438ce06bee8cdf92d0f091e24d12a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Confidence intervals</topic><topic>Gastric cancer</topic><topic>Neutrophils</topic><topic>neutrophil–lymphocyte ratio</topic><topic>postoperative cognitive dysfunction</topic><topic>risk factor</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yong, Rong</creatorcontrib><creatorcontrib>Meng, Yongsheng</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Geriatrics & gerontology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yong, Rong</au><au>Meng, Yongsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preoperative neutrophil–lymphocyte ratio, an independent risk factor for postoperative cognitive dysfunction in elderly patients with gastric cancer</atitle><jtitle>Geriatrics & gerontology international</jtitle><date>2020-10</date><risdate>2020</risdate><volume>20</volume><issue>10</issue><spage>927</spage><epage>931</epage><pages>927-931</pages><issn>1444-1586</issn><eissn>1447-0594</eissn><abstract>Aim
This study aimed to investigate the potential risk factors for postoperative cognitive dysfunction (POCD) in elderly patients with gastric cancer (GC) after radical gastrectomy.
Methods
In total, 221 elderly patients with GC who were scheduled to undergo selective radical gastrectomy in our hospital were enrolled in this study. To define early POCD, the neuropsychological assessment was carried out 1 day before surgery and 7 days after surgery. Receiver operating characteristic curve analysis was carried out to evaluate the predicative and cut‐off values of risk factors, including neutrophil–lymphocyte ratio (NLR) for early POCD. The univariate and multivariate logistic regression analyses were performed to investigate risk factors for early POCD.
Results
Of the 221 enrolled elderly patients with GC, 42 were identified as early POCD with an incidence of 19.0% (42 of 221). Receiver operating characteristic curve analysis indicated that NLR was a significant predictor for POCD with a cut‐off value of 2.50 and an area under the curve of 0.711 (95% confidence interval: 0.624–0.798, P < 0.001). Preoperative NLR (≥2.50) was the only independent risk factor associated with POCD (odds ratio: 2.44, 95% confidence interval: 1.52–3.68, P = 0.013) by the multivariate logistic regression analysis.
Conclusions
Preoperative NLR level was an independent risk factor for POCD in elderly patients with GC undergoing curative resection. Geriatr Gerontol Int 2020; 20: 927–931.</abstract><cop>Kyoto, Japan</cop><pub>John Wiley & Sons Australia, Ltd</pub><doi>10.1111/ggi.14016</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0001-8063-7682</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1444-1586 |
| ispartof | Geriatrics & gerontology international, 2020-10, Vol.20 (10), p.927-931 |
| issn | 1444-1586 1447-0594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2436870669 |
| source | Access via Wiley Online Library |
| subjects | Confidence intervals Gastric cancer Neutrophils neutrophil–lymphocyte ratio postoperative cognitive dysfunction risk factor Risk factors |
| title | Preoperative neutrophil–lymphocyte ratio, an independent risk factor for postoperative cognitive dysfunction in elderly patients with gastric cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T23%3A26%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Preoperative%20neutrophil%E2%80%93lymphocyte%20ratio,%20an%20independent%20risk%20factor%20for%20postoperative%20cognitive%20dysfunction%20in%20elderly%20patients%20with%20gastric%20cancer&rft.jtitle=Geriatrics%20&%20gerontology%20international&rft.au=Yong,%20Rong&rft.date=2020-10&rft.volume=20&rft.issue=10&rft.spage=927&rft.epage=931&rft.pages=927-931&rft.issn=1444-1586&rft.eissn=1447-0594&rft_id=info:doi/10.1111/ggi.14016&rft_dat=%3Cproquest_cross%3E2447630823%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2447630823&rft_id=info:pmid/&rfr_iscdi=true |