Electrospun nanofibers in cancer research: from engineering of in vitro 3D cancer models to therapy
Electrospinning is historically related to tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that are extremely similar to those of the extracellular matrix of living tissues. The general interest in electrospun fibrous matr...
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| Veröffentlicht in: | Biomaterials science 2020-09, Vol.8 (18), p.4887-4905 |
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| creator | Cavo, Marta Serio, Francesca Kale, Narendra R D'Amone, Eliana Gigli, Giuseppe Del Mercato, Loretta L |
| description | Electrospinning is historically related to tissue engineering due to its ability to produce nano-/microscale fibrous materials with mechanical and functional properties that are extremely similar to those of the extracellular matrix of living tissues. The general interest in electrospun fibrous matrices has recently expanded to cancer research both as scaffolds for in vitro cancer modelling and as patches for in vivo therapeutic delivery. In this review, we examine electrospinning by providing a brief description of the process and overview of most materials used in this process, discussing the effect of changing the process parameters on fiber conformations and assemblies. Then, we describe two different applications of electrospinning in service of cancer research: firstly, as three-dimensional (3D) fibrous materials for generating in vitro pre-clinical cancer models; and secondly, as patches encapsulating anticancer agents for in vivo delivery. |
| doi_str_mv | 10.1039/d0bm00390e |
| format | Article |
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| source | MEDLINE; Royal Society Of Chemistry Journals 2008- |
| subjects | Anticancer properties Cancer Electrospinning Extracellular Matrix Medical research Nanofibers Neoplasms - drug therapy Process parameters Three dimensional models Tissue Engineering Tissue Scaffolds |
| title | Electrospun nanofibers in cancer research: from engineering of in vitro 3D cancer models to therapy |
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