A novel system exploits bone debris for implant osseointegration
Background Bone debris generated during site preparation is generally evacuated with irrigation; here, we evaluated whether retention of this autologous material improved the rate of peri‐implant bone formation. Methods In 25 rats, a miniature implant system composed of an osseo‐shaping tool and a t...
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| Veröffentlicht in: | Journal of periodontology (1970) 2021-05, Vol.92 (5), p.716-726 |
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| container_title | Journal of periodontology (1970) |
| container_volume | 92 |
| creator | Coyac, Benjamin R. Salvi, Giuseppe Leahy, Brian Li, Zhijun Salmon, Benjamin Hoffmann, Waldemar Helms, Jill A. |
| description | Background
Bone debris generated during site preparation is generally evacuated with irrigation; here, we evaluated whether retention of this autologous material improved the rate of peri‐implant bone formation.
Methods
In 25 rats, a miniature implant system composed of an osseo‐shaping tool and a tri‐oval‐shaped implant was compared against a conventional drill and round implant system. A split‐mouth design was used, and fresh extraction sockets served as implant sites. Histology/histomorphometry, immunohistochemistry, and microcomputed tomography (μCT) imaging were performed immediately after implant placement, and on post‐surgery days 3, 7, 14, and 28.
Results
Compared with a conventional drill design, the osseo‐shaping tool produced a textured osteotomy surface and viable bone debris that was retained in the peri‐implant environment. Proliferating osteoprogenitor cells, identified by PCNA and Runx2 expression, contributed to faster peri‐implant bone formation. Although all implants osseointegrated, sites prepared with the osseo‐shaping tool showed evidence of new peri‐implant bone sooner than controls.
Conclusion
Bone debris produced by an osseo‐shaping tool directly contributed to faster peri‐implant bone formation and implant osseointegration. |
| doi_str_mv | 10.1002/JPER.20-0099 |
| format | Article |
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Bone debris generated during site preparation is generally evacuated with irrigation; here, we evaluated whether retention of this autologous material improved the rate of peri‐implant bone formation.
Methods
In 25 rats, a miniature implant system composed of an osseo‐shaping tool and a tri‐oval‐shaped implant was compared against a conventional drill and round implant system. A split‐mouth design was used, and fresh extraction sockets served as implant sites. Histology/histomorphometry, immunohistochemistry, and microcomputed tomography (μCT) imaging were performed immediately after implant placement, and on post‐surgery days 3, 7, 14, and 28.
Results
Compared with a conventional drill design, the osseo‐shaping tool produced a textured osteotomy surface and viable bone debris that was retained in the peri‐implant environment. Proliferating osteoprogenitor cells, identified by PCNA and Runx2 expression, contributed to faster peri‐implant bone formation. Although all implants osseointegrated, sites prepared with the osseo‐shaping tool showed evidence of new peri‐implant bone sooner than controls.
Conclusion
Bone debris produced by an osseo‐shaping tool directly contributed to faster peri‐implant bone formation and implant osseointegration.</description><identifier>ISSN: 0022-3492</identifier><identifier>EISSN: 1943-3670</identifier><identifier>DOI: 10.1002/JPER.20-0099</identifier><language>eng</language><subject>autografts ; bone graft(s) ; bone regeneration ; dental implantation ; Dentistry ; implantology</subject><ispartof>Journal of periodontology (1970), 2021-05, Vol.92 (5), p.716-726</ispartof><rights>2020 American Academy of Periodontology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3122-ed5b249303c2ec1e7ac64d1d52e988a692edfc85fffcfbba487b5035240c72fd3</citedby><cites>FETCH-LOGICAL-c3122-ed5b249303c2ec1e7ac64d1d52e988a692edfc85fffcfbba487b5035240c72fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2FJPER.20-0099$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2FJPER.20-0099$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids></links><search><creatorcontrib>Coyac, Benjamin R.</creatorcontrib><creatorcontrib>Salvi, Giuseppe</creatorcontrib><creatorcontrib>Leahy, Brian</creatorcontrib><creatorcontrib>Li, Zhijun</creatorcontrib><creatorcontrib>Salmon, Benjamin</creatorcontrib><creatorcontrib>Hoffmann, Waldemar</creatorcontrib><creatorcontrib>Helms, Jill A.</creatorcontrib><title>A novel system exploits bone debris for implant osseointegration</title><title>Journal of periodontology (1970)</title><description>Background
Bone debris generated during site preparation is generally evacuated with irrigation; here, we evaluated whether retention of this autologous material improved the rate of peri‐implant bone formation.
Methods
In 25 rats, a miniature implant system composed of an osseo‐shaping tool and a tri‐oval‐shaped implant was compared against a conventional drill and round implant system. A split‐mouth design was used, and fresh extraction sockets served as implant sites. Histology/histomorphometry, immunohistochemistry, and microcomputed tomography (μCT) imaging were performed immediately after implant placement, and on post‐surgery days 3, 7, 14, and 28.
Results
Compared with a conventional drill design, the osseo‐shaping tool produced a textured osteotomy surface and viable bone debris that was retained in the peri‐implant environment. Proliferating osteoprogenitor cells, identified by PCNA and Runx2 expression, contributed to faster peri‐implant bone formation. Although all implants osseointegrated, sites prepared with the osseo‐shaping tool showed evidence of new peri‐implant bone sooner than controls.
Conclusion
Bone debris produced by an osseo‐shaping tool directly contributed to faster peri‐implant bone formation and implant osseointegration.</description><subject>autografts</subject><subject>bone graft(s)</subject><subject>bone regeneration</subject><subject>dental implantation</subject><subject>Dentistry</subject><subject>implantology</subject><issn>0022-3492</issn><issn>1943-3670</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EEqWw4wO8ZEGKX3l4R1WVlyqBEKwtxxkjoyQOdgrk73Epa1ajqzmauToInVOyoISwq4en9fOCkYwQKQ_QjErBM16U5BDN0pplXEh2jE5ifE-RCk5m6HqJe_8JLY5THKHD8D203o0R174H3EAdXMTWB-y6odX9iH2M4F0_wlvQo_P9KTqyuo1w9jfn6PVm_bK6yzaPt_er5SYznKbX0OQ1E5ITbhgYCqU2hWhokzOQVaULyaCxpsqttcbWtRZVWeeE50wQUzLb8Dm62N8dgv_YQhxV56KBNpUCv42KCV5UhcylTOjlHjUhtQ1g1RBcp8OkKFE7UWonSjGidqISzvf4l2th-pf9DZQUnPEfC11rjA</recordid><startdate>202105</startdate><enddate>202105</enddate><creator>Coyac, Benjamin R.</creator><creator>Salvi, Giuseppe</creator><creator>Leahy, Brian</creator><creator>Li, Zhijun</creator><creator>Salmon, Benjamin</creator><creator>Hoffmann, Waldemar</creator><creator>Helms, Jill A.</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202105</creationdate><title>A novel system exploits bone debris for implant osseointegration</title><author>Coyac, Benjamin R. ; Salvi, Giuseppe ; Leahy, Brian ; Li, Zhijun ; Salmon, Benjamin ; Hoffmann, Waldemar ; Helms, Jill A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3122-ed5b249303c2ec1e7ac64d1d52e988a692edfc85fffcfbba487b5035240c72fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>autografts</topic><topic>bone graft(s)</topic><topic>bone regeneration</topic><topic>dental implantation</topic><topic>Dentistry</topic><topic>implantology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coyac, Benjamin R.</creatorcontrib><creatorcontrib>Salvi, Giuseppe</creatorcontrib><creatorcontrib>Leahy, Brian</creatorcontrib><creatorcontrib>Li, Zhijun</creatorcontrib><creatorcontrib>Salmon, Benjamin</creatorcontrib><creatorcontrib>Hoffmann, Waldemar</creatorcontrib><creatorcontrib>Helms, Jill A.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of periodontology (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coyac, Benjamin R.</au><au>Salvi, Giuseppe</au><au>Leahy, Brian</au><au>Li, Zhijun</au><au>Salmon, Benjamin</au><au>Hoffmann, Waldemar</au><au>Helms, Jill A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel system exploits bone debris for implant osseointegration</atitle><jtitle>Journal of periodontology (1970)</jtitle><date>2021-05</date><risdate>2021</risdate><volume>92</volume><issue>5</issue><spage>716</spage><epage>726</epage><pages>716-726</pages><issn>0022-3492</issn><eissn>1943-3670</eissn><abstract>Background
Bone debris generated during site preparation is generally evacuated with irrigation; here, we evaluated whether retention of this autologous material improved the rate of peri‐implant bone formation.
Methods
In 25 rats, a miniature implant system composed of an osseo‐shaping tool and a tri‐oval‐shaped implant was compared against a conventional drill and round implant system. A split‐mouth design was used, and fresh extraction sockets served as implant sites. Histology/histomorphometry, immunohistochemistry, and microcomputed tomography (μCT) imaging were performed immediately after implant placement, and on post‐surgery days 3, 7, 14, and 28.
Results
Compared with a conventional drill design, the osseo‐shaping tool produced a textured osteotomy surface and viable bone debris that was retained in the peri‐implant environment. Proliferating osteoprogenitor cells, identified by PCNA and Runx2 expression, contributed to faster peri‐implant bone formation. Although all implants osseointegrated, sites prepared with the osseo‐shaping tool showed evidence of new peri‐implant bone sooner than controls.
Conclusion
Bone debris produced by an osseo‐shaping tool directly contributed to faster peri‐implant bone formation and implant osseointegration.</abstract><doi>10.1002/JPER.20-0099</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3492 |
| ispartof | Journal of periodontology (1970), 2021-05, Vol.92 (5), p.716-726 |
| issn | 0022-3492 1943-3670 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2436869599 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | autografts bone graft(s) bone regeneration dental implantation Dentistry implantology |
| title | A novel system exploits bone debris for implant osseointegration |
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