Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women

Performance of early pregnancy HbA1c for predicting gestational diabetes mellitus and adverse pregnancy outcomes in obese European women

•Early pregnancy HbA1c is a poor predictor of gestational diabetes.•An HbA1c ≥ 5.7% (39 mmol/mol) has poor sensitivity for GDM regardless of gestation.•An HbA1c ≥ 5.7% (39 mmol/mol) was not associated with greater risk of adverse outcomes. To investigate the performance of early pregnancy HbA1c for...

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Veröffentlicht in:Diabetes research and clinical practice 2020-10, Vol.168, p.108378-108378, Article 108378
Hauptverfasser: Immanuel, Jincy, Simmons, David, Desoye, Gernot, Corcoy, Rosa, Adelantado, Juan M., Devlieger, Roland, Lapolla, Annunziata, Dalfra, Maria G., Bertolotto, Alessandra, Harreiter, Jürgen, Wender-Ozegowska, Ewa, Zawiejska, Agnieszka, Dunne, Fidelma P., Damm, Peter, Mathiesen, Elisabeth R., Jensen, Dorte M., Andersen, Lise Lotte T., Hill, David J., Jelsma, Judith G.M., Snoek, Frank J., Scharnagl, Hubert, Galjaard, Sander, Kautzky-Willer, Alexandra, VAN Poppel, Mireille N.M.
Format: Artikel
Sprache:eng
Schlagworte:
Diagnostic threshold
Gestational diabetes mellitus
Hemoglobin A1c
Odds Ratio
Pregnancy
Pregnancy outcome
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Zusammenfassung:•Early pregnancy HbA1c is a poor predictor of gestational diabetes.•An HbA1c ≥ 5.7% (39 mmol/mol) has poor sensitivity for GDM regardless of gestation.•An HbA1c ≥ 5.7% (39 mmol/mol) was not associated with greater risk of adverse outcomes. To investigate the performance of early pregnancy HbA1c for predicting gestational diabetes mellitus (GDM) and adverse pregnancy outcomes in obese women. Post hoc analysis using data from the Vitamin D And Lifestyle Intervention for GDM prevention trials conducted across 9 European countries (2012–2014). Pregnant women (BMI ≥ 29 kg/m2) underwent a baseline HbA1c and oral glucose tolerance tests at 
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2020.108378