Acute liver failure and HELLP syndrome: A clinical case and literature review
HELLP syndrome is a pregnancy-related liver disease associated with increased maternal and foetal mortality. In rare cases, it can lead to the development of a subcapsular hepatic haematoma as well as its rupture. This rupture is life-threatening if not urgently treated. We describe a clinical case...
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| Veröffentlicht in: | Clinics and research in hepatology and gastroenterology 2021-03, Vol.45 (2), p.101498-101498, Article 101498 |
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| container_issue | 2 |
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| container_title | Clinics and research in hepatology and gastroenterology |
| container_volume | 45 |
| creator | Mazzola, Alessandra Magro, Bianca Perdigao, Fabiano Charlotte, Fréderic Atif, Muhammad Goumard, Claire Scatton, Olivier Conti, Filomena |
| description | HELLP syndrome is a pregnancy-related liver disease associated with increased maternal and foetal mortality. In rare cases, it can lead to the development of a subcapsular hepatic haematoma as well as its rupture. This rupture is life-threatening if not urgently treated.
We describe a clinical case of HELLP syndrome involving a ruptured subcapsular liver haematoma and contextualise this with a literature overview.
A 39-year-old woman of 40 weeks’ gestation presented to her local Emergency Department with symptoms and serology classically associated with HELLP syndrome. However, she clinically deteriorated and developed a ruptured subcapsular haematoma. She underwent an emergency Caesarean section at her initial hospital. Upon clinical stabilisation, she was transferred to our transplant unit for an urgent liver transplant.
LT is a life-saving procedure for patients with acute liver failure secondary to HELLP syndrome. These patients should be immediately referred to a high-volume transplant centre. |
| doi_str_mv | 10.1016/j.clinre.2020.07.005 |
| format | Article |
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We describe a clinical case of HELLP syndrome involving a ruptured subcapsular liver haematoma and contextualise this with a literature overview.
A 39-year-old woman of 40 weeks’ gestation presented to her local Emergency Department with symptoms and serology classically associated with HELLP syndrome. However, she clinically deteriorated and developed a ruptured subcapsular haematoma. She underwent an emergency Caesarean section at her initial hospital. Upon clinical stabilisation, she was transferred to our transplant unit for an urgent liver transplant.
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We describe a clinical case of HELLP syndrome involving a ruptured subcapsular liver haematoma and contextualise this with a literature overview.
A 39-year-old woman of 40 weeks’ gestation presented to her local Emergency Department with symptoms and serology classically associated with HELLP syndrome. However, she clinically deteriorated and developed a ruptured subcapsular haematoma. She underwent an emergency Caesarean section at her initial hospital. Upon clinical stabilisation, she was transferred to our transplant unit for an urgent liver transplant.
LT is a life-saving procedure for patients with acute liver failure secondary to HELLP syndrome. These patients should be immediately referred to a high-volume transplant centre.</description><subject>Haematoma</subject><subject>HELLP syndrome</subject><subject>Liver necrosis</subject><subject>Liver transplantation</subject><issn>2210-7401</issn><issn>2210-741X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMottS-gcgs3XQ8yVyScSGUUi9Q0YWCu5BkzkDKXGoyU-nbO8PULs0mgfP9-TkfIdcUQgo0vduGprS1w5ABgxB4CJCckSljFBY8pl_npzfQCZl7v4X-xAkITi_JJGKCCR7zKXldmq7FoLR7dEGhbNk5DFSdB8_rzeY98Ic6d02F98EyGBqtUWVglB-Z0rboVDtEHO4t_lyRi0KVHufHe0Y-H9cfq-fF5u3pZbXcLEyUsnaRoKFGZ1kS5UpkOeVa5Vgwhlk_SVIKGoTWkdZJlCUCtMliJVJqCsERooRFM3I7_rtzzXeHvpWV9QbLUtXYdF6yOEpFymkqejQeUeMa7x0WcudspdxBUpCDS7mVo0s5uJTAZe-yj90cGzpdYX4K_ZnrgYcRwH7PfncnvbFYG8ytQ9PKvLH_N_wCgUOGEw</recordid><startdate>202103</startdate><enddate>202103</enddate><creator>Mazzola, Alessandra</creator><creator>Magro, Bianca</creator><creator>Perdigao, Fabiano</creator><creator>Charlotte, Fréderic</creator><creator>Atif, Muhammad</creator><creator>Goumard, Claire</creator><creator>Scatton, Olivier</creator><creator>Conti, Filomena</creator><general>Elsevier Masson SAS</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202103</creationdate><title>Acute liver failure and HELLP syndrome: A clinical case and literature review</title><author>Mazzola, Alessandra ; Magro, Bianca ; Perdigao, Fabiano ; Charlotte, Fréderic ; Atif, Muhammad ; Goumard, Claire ; Scatton, Olivier ; Conti, Filomena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-5ec1cb9953da89d17badef22e95ec5610b08bb3bb539580bc94a861cf87e03523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Haematoma</topic><topic>HELLP syndrome</topic><topic>Liver necrosis</topic><topic>Liver transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mazzola, Alessandra</creatorcontrib><creatorcontrib>Magro, Bianca</creatorcontrib><creatorcontrib>Perdigao, Fabiano</creatorcontrib><creatorcontrib>Charlotte, Fréderic</creatorcontrib><creatorcontrib>Atif, Muhammad</creatorcontrib><creatorcontrib>Goumard, Claire</creatorcontrib><creatorcontrib>Scatton, Olivier</creatorcontrib><creatorcontrib>Conti, Filomena</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinics and research in hepatology and gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mazzola, Alessandra</au><au>Magro, Bianca</au><au>Perdigao, Fabiano</au><au>Charlotte, Fréderic</au><au>Atif, Muhammad</au><au>Goumard, Claire</au><au>Scatton, Olivier</au><au>Conti, Filomena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute liver failure and HELLP syndrome: A clinical case and literature review</atitle><jtitle>Clinics and research in hepatology and gastroenterology</jtitle><addtitle>Clin Res Hepatol Gastroenterol</addtitle><date>2021-03</date><risdate>2021</risdate><volume>45</volume><issue>2</issue><spage>101498</spage><epage>101498</epage><pages>101498-101498</pages><artnum>101498</artnum><issn>2210-7401</issn><eissn>2210-741X</eissn><abstract>HELLP syndrome is a pregnancy-related liver disease associated with increased maternal and foetal mortality. In rare cases, it can lead to the development of a subcapsular hepatic haematoma as well as its rupture. This rupture is life-threatening if not urgently treated.
We describe a clinical case of HELLP syndrome involving a ruptured subcapsular liver haematoma and contextualise this with a literature overview.
A 39-year-old woman of 40 weeks’ gestation presented to her local Emergency Department with symptoms and serology classically associated with HELLP syndrome. However, she clinically deteriorated and developed a ruptured subcapsular haematoma. She underwent an emergency Caesarean section at her initial hospital. Upon clinical stabilisation, she was transferred to our transplant unit for an urgent liver transplant.
LT is a life-saving procedure for patients with acute liver failure secondary to HELLP syndrome. These patients should be immediately referred to a high-volume transplant centre.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>32828747</pmid><doi>10.1016/j.clinre.2020.07.005</doi><tpages>1</tpages></addata></record> |
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| ispartof | Clinics and research in hepatology and gastroenterology, 2021-03, Vol.45 (2), p.101498-101498, Article 101498 |
| issn | 2210-7401 2210-741X |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Haematoma HELLP syndrome Liver necrosis Liver transplantation |
| title | Acute liver failure and HELLP syndrome: A clinical case and literature review |
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