Effects of Chinese herbal medicines on dementia risk in patients with sleep disorders in Taiwan
Sleep disorders affect an estimated 150 million people worldwide and result in adverse health, safety, and work performance-related outcomes that have important economic consequences. In Taiwan, Chinese herbal medicine (CHM) is a complementary natural medicine and has been widely used as an adjuncti...
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| Veröffentlicht in: | Journal of ethnopharmacology 2021-01, Vol.264, p.113267-113267, Article 113267 |
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| creator | Chen, Chao-Jung Liu, Xiang Chiou, Jian-Shiun Hang, Liang-Wen Li, Te-Mao Tsai, Fuu-Jen Ko, Cheng-Hang Lin, Ting-Hsu Liao, Chiu-Chu Huang, Shao-Mei Liang, Wen-Miin Lin, Ying-Ju |
| description | Sleep disorders affect an estimated 150 million people worldwide and result in adverse health, safety, and work performance-related outcomes that have important economic consequences. In Taiwan, Chinese herbal medicine (CHM) is a complementary natural medicine and has been widely used as an adjunctive therapy.
This study aimed to investigate the effect of CHM on dementia risk in patients with sleep disorders in Taiwan.
We identified 124,605 patients with sleep disorders between the ages of 20 and 60 years. Of these, 5876 CHM users and 5876 non-CHM users were matched according to age and gender. The chi-squared test, Cox proportional hazard model, Kaplan-Meier method, and log-rank test were used for the comparisons. Association rule mining and network analysis were applied to determine a CHM pattern specialized for sleep disorders.
More CHM users did not use sleeping pills than non-CHM users. CHM users had a lower risk of dementia than non-CHM users after adjusting for age, gender, and sleeping pill use (hazard ratio (HR): 0.469, 95% CI = 0.289–0.760; p-value = 0.002). The cumulative incidence of dementia was lower among CHM users (long-rank test, p-value |
| doi_str_mv | 10.1016/j.jep.2020.113267 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2436403219</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874120331494</els_id><sourcerecordid>2436403219</sourcerecordid><originalsourceid>FETCH-LOGICAL-c353t-a25cd4a44aa3230eb0b6a208d21ff1ff764df14928e5bca0e7c1b1e5bbbf5b643</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMotlZ_gBfJ0cvWfO1miycp9QMKXuo5JNkJzbrdXZOt4r83S6tHYWAmwzMv5EHompI5JbS4q-c19HNGWHpTzgp5gqa0lCyTueSnaEq4LLNSCjpBFzHWhBBJBTlHE85KNtYUqZVzYIeIO4eXW99CBLyFYHSDd1B5O25w1-IKdtAOXuPg4zv2Le714NMm4i8_bHFsAHpc-diFCkIcgY32X7q9RGdONxGujn2G3h5Xm-Vztn59elk-rDPLcz5kmuW2EloIrTnjBAwxhWakrBh1LpUsROWoWLAScmM1AWmpoWk2xuWmEHyGbg-5feg-9hAHtfPRQtPoFrp9VEzwQhDO6CKh9IDa0MUYwKk--J0O34oSNXpVtUpe1ehVHbymm5tj_N4kL38XvyITcH8AIH3y00NQ0SY_NjkMya-qOv9P_A8ueYlL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2436403219</pqid></control><display><type>article</type><title>Effects of Chinese herbal medicines on dementia risk in patients with sleep disorders in Taiwan</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Chen, Chao-Jung ; Liu, Xiang ; Chiou, Jian-Shiun ; Hang, Liang-Wen ; Li, Te-Mao ; Tsai, Fuu-Jen ; Ko, Cheng-Hang ; Lin, Ting-Hsu ; Liao, Chiu-Chu ; Huang, Shao-Mei ; Liang, Wen-Miin ; Lin, Ying-Ju</creator><creatorcontrib>Chen, Chao-Jung ; Liu, Xiang ; Chiou, Jian-Shiun ; Hang, Liang-Wen ; Li, Te-Mao ; Tsai, Fuu-Jen ; Ko, Cheng-Hang ; Lin, Ting-Hsu ; Liao, Chiu-Chu ; Huang, Shao-Mei ; Liang, Wen-Miin ; Lin, Ying-Ju</creatorcontrib><description>Sleep disorders affect an estimated 150 million people worldwide and result in adverse health, safety, and work performance-related outcomes that have important economic consequences. In Taiwan, Chinese herbal medicine (CHM) is a complementary natural medicine and has been widely used as an adjunctive therapy.
This study aimed to investigate the effect of CHM on dementia risk in patients with sleep disorders in Taiwan.
We identified 124,605 patients with sleep disorders between the ages of 20 and 60 years. Of these, 5876 CHM users and 5876 non-CHM users were matched according to age and gender. The chi-squared test, Cox proportional hazard model, Kaplan-Meier method, and log-rank test were used for the comparisons. Association rule mining and network analysis were applied to determine a CHM pattern specialized for sleep disorders.
More CHM users did not use sleeping pills than non-CHM users. CHM users had a lower risk of dementia than non-CHM users after adjusting for age, gender, and sleeping pill use (hazard ratio (HR): 0.469, 95% CI = 0.289–0.760; p-value = 0.002). The cumulative incidence of dementia was lower among CHM users (long-rank test, p-value < 0.001). Association rule mining and network analysis showed that Ye-Jiao-Teng (YJT; Caulis Polygoni Multiflori; Polygonum multiflorum Thunb), Suan-Zao-Ren-Tang (SZRT), Jia-Wei-Xiao-Yao-San (JWXYS), He-Huan-Pi (HHP; Cortex Albizziae; Albizia julibrissin Durazz.), and Suan-Zao-Ren (SZR; Semen Zizyphi Spinosae; Ziziphus jujuba Mill.) were important CHMs for patients with sleep disorders in Taiwan.
A comprehensive list of herbal medicines may be useful for the clinical treatment of patients with sleep disorders, and for future scientific investigations into the prevention of dementia in these patients.
[Display omitted]</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2020.113267</identifier><identifier>PMID: 32822822</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Association rule mining ; Chinese herbal medicine ; Cohort Studies ; Dementia ; Dementia - drug therapy ; Dementia - ethnology ; Drugs, Chinese Herbal - isolation & purification ; Drugs, Chinese Herbal - therapeutic use ; Female ; Humans ; Longitudinal Studies ; Male ; Medicine, Chinese Traditional - methods ; Middle Aged ; Network analysis ; Retrospective Studies ; Risk Factors ; Sleep disorders ; Sleep Wake Disorders - drug therapy ; Sleep Wake Disorders - ethnology ; Taiwan - ethnology ; Treatment Outcome ; Young Adult</subject><ispartof>Journal of ethnopharmacology, 2021-01, Vol.264, p.113267-113267, Article 113267</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-a25cd4a44aa3230eb0b6a208d21ff1ff764df14928e5bca0e7c1b1e5bbbf5b643</citedby><cites>FETCH-LOGICAL-c353t-a25cd4a44aa3230eb0b6a208d21ff1ff764df14928e5bca0e7c1b1e5bbbf5b643</cites><orcidid>0000-0002-9334-603X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874120331494$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32822822$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Chao-Jung</creatorcontrib><creatorcontrib>Liu, Xiang</creatorcontrib><creatorcontrib>Chiou, Jian-Shiun</creatorcontrib><creatorcontrib>Hang, Liang-Wen</creatorcontrib><creatorcontrib>Li, Te-Mao</creatorcontrib><creatorcontrib>Tsai, Fuu-Jen</creatorcontrib><creatorcontrib>Ko, Cheng-Hang</creatorcontrib><creatorcontrib>Lin, Ting-Hsu</creatorcontrib><creatorcontrib>Liao, Chiu-Chu</creatorcontrib><creatorcontrib>Huang, Shao-Mei</creatorcontrib><creatorcontrib>Liang, Wen-Miin</creatorcontrib><creatorcontrib>Lin, Ying-Ju</creatorcontrib><title>Effects of Chinese herbal medicines on dementia risk in patients with sleep disorders in Taiwan</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Sleep disorders affect an estimated 150 million people worldwide and result in adverse health, safety, and work performance-related outcomes that have important economic consequences. In Taiwan, Chinese herbal medicine (CHM) is a complementary natural medicine and has been widely used as an adjunctive therapy.
This study aimed to investigate the effect of CHM on dementia risk in patients with sleep disorders in Taiwan.
We identified 124,605 patients with sleep disorders between the ages of 20 and 60 years. Of these, 5876 CHM users and 5876 non-CHM users were matched according to age and gender. The chi-squared test, Cox proportional hazard model, Kaplan-Meier method, and log-rank test were used for the comparisons. Association rule mining and network analysis were applied to determine a CHM pattern specialized for sleep disorders.
More CHM users did not use sleeping pills than non-CHM users. CHM users had a lower risk of dementia than non-CHM users after adjusting for age, gender, and sleeping pill use (hazard ratio (HR): 0.469, 95% CI = 0.289–0.760; p-value = 0.002). The cumulative incidence of dementia was lower among CHM users (long-rank test, p-value < 0.001). Association rule mining and network analysis showed that Ye-Jiao-Teng (YJT; Caulis Polygoni Multiflori; Polygonum multiflorum Thunb), Suan-Zao-Ren-Tang (SZRT), Jia-Wei-Xiao-Yao-San (JWXYS), He-Huan-Pi (HHP; Cortex Albizziae; Albizia julibrissin Durazz.), and Suan-Zao-Ren (SZR; Semen Zizyphi Spinosae; Ziziphus jujuba Mill.) were important CHMs for patients with sleep disorders in Taiwan.
A comprehensive list of herbal medicines may be useful for the clinical treatment of patients with sleep disorders, and for future scientific investigations into the prevention of dementia in these patients.
[Display omitted]</description><subject>Adult</subject><subject>Association rule mining</subject><subject>Chinese herbal medicine</subject><subject>Cohort Studies</subject><subject>Dementia</subject><subject>Dementia - drug therapy</subject><subject>Dementia - ethnology</subject><subject>Drugs, Chinese Herbal - isolation & purification</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medicine, Chinese Traditional - methods</subject><subject>Middle Aged</subject><subject>Network analysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sleep disorders</subject><subject>Sleep Wake Disorders - drug therapy</subject><subject>Sleep Wake Disorders - ethnology</subject><subject>Taiwan - ethnology</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotlZ_gBfJ0cvWfO1miycp9QMKXuo5JNkJzbrdXZOt4r83S6tHYWAmwzMv5EHompI5JbS4q-c19HNGWHpTzgp5gqa0lCyTueSnaEq4LLNSCjpBFzHWhBBJBTlHE85KNtYUqZVzYIeIO4eXW99CBLyFYHSDd1B5O25w1-IKdtAOXuPg4zv2Le714NMm4i8_bHFsAHpc-diFCkIcgY32X7q9RGdONxGujn2G3h5Xm-Vztn59elk-rDPLcz5kmuW2EloIrTnjBAwxhWakrBh1LpUsROWoWLAScmM1AWmpoWk2xuWmEHyGbg-5feg-9hAHtfPRQtPoFrp9VEzwQhDO6CKh9IDa0MUYwKk--J0O34oSNXpVtUpe1ehVHbymm5tj_N4kL38XvyITcH8AIH3y00NQ0SY_NjkMya-qOv9P_A8ueYlL</recordid><startdate>20210110</startdate><enddate>20210110</enddate><creator>Chen, Chao-Jung</creator><creator>Liu, Xiang</creator><creator>Chiou, Jian-Shiun</creator><creator>Hang, Liang-Wen</creator><creator>Li, Te-Mao</creator><creator>Tsai, Fuu-Jen</creator><creator>Ko, Cheng-Hang</creator><creator>Lin, Ting-Hsu</creator><creator>Liao, Chiu-Chu</creator><creator>Huang, Shao-Mei</creator><creator>Liang, Wen-Miin</creator><creator>Lin, Ying-Ju</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9334-603X</orcidid></search><sort><creationdate>20210110</creationdate><title>Effects of Chinese herbal medicines on dementia risk in patients with sleep disorders in Taiwan</title><author>Chen, Chao-Jung ; Liu, Xiang ; Chiou, Jian-Shiun ; Hang, Liang-Wen ; Li, Te-Mao ; Tsai, Fuu-Jen ; Ko, Cheng-Hang ; Lin, Ting-Hsu ; Liao, Chiu-Chu ; Huang, Shao-Mei ; Liang, Wen-Miin ; Lin, Ying-Ju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-a25cd4a44aa3230eb0b6a208d21ff1ff764df14928e5bca0e7c1b1e5bbbf5b643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Association rule mining</topic><topic>Chinese herbal medicine</topic><topic>Cohort Studies</topic><topic>Dementia</topic><topic>Dementia - drug therapy</topic><topic>Dementia - ethnology</topic><topic>Drugs, Chinese Herbal - isolation & purification</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medicine, Chinese Traditional - methods</topic><topic>Middle Aged</topic><topic>Network analysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sleep disorders</topic><topic>Sleep Wake Disorders - drug therapy</topic><topic>Sleep Wake Disorders - ethnology</topic><topic>Taiwan - ethnology</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Chao-Jung</creatorcontrib><creatorcontrib>Liu, Xiang</creatorcontrib><creatorcontrib>Chiou, Jian-Shiun</creatorcontrib><creatorcontrib>Hang, Liang-Wen</creatorcontrib><creatorcontrib>Li, Te-Mao</creatorcontrib><creatorcontrib>Tsai, Fuu-Jen</creatorcontrib><creatorcontrib>Ko, Cheng-Hang</creatorcontrib><creatorcontrib>Lin, Ting-Hsu</creatorcontrib><creatorcontrib>Liao, Chiu-Chu</creatorcontrib><creatorcontrib>Huang, Shao-Mei</creatorcontrib><creatorcontrib>Liang, Wen-Miin</creatorcontrib><creatorcontrib>Lin, Ying-Ju</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Chao-Jung</au><au>Liu, Xiang</au><au>Chiou, Jian-Shiun</au><au>Hang, Liang-Wen</au><au>Li, Te-Mao</au><au>Tsai, Fuu-Jen</au><au>Ko, Cheng-Hang</au><au>Lin, Ting-Hsu</au><au>Liao, Chiu-Chu</au><au>Huang, Shao-Mei</au><au>Liang, Wen-Miin</au><au>Lin, Ying-Ju</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Chinese herbal medicines on dementia risk in patients with sleep disorders in Taiwan</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2021-01-10</date><risdate>2021</risdate><volume>264</volume><spage>113267</spage><epage>113267</epage><pages>113267-113267</pages><artnum>113267</artnum><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Sleep disorders affect an estimated 150 million people worldwide and result in adverse health, safety, and work performance-related outcomes that have important economic consequences. In Taiwan, Chinese herbal medicine (CHM) is a complementary natural medicine and has been widely used as an adjunctive therapy.
This study aimed to investigate the effect of CHM on dementia risk in patients with sleep disorders in Taiwan.
We identified 124,605 patients with sleep disorders between the ages of 20 and 60 years. Of these, 5876 CHM users and 5876 non-CHM users were matched according to age and gender. The chi-squared test, Cox proportional hazard model, Kaplan-Meier method, and log-rank test were used for the comparisons. Association rule mining and network analysis were applied to determine a CHM pattern specialized for sleep disorders.
More CHM users did not use sleeping pills than non-CHM users. CHM users had a lower risk of dementia than non-CHM users after adjusting for age, gender, and sleeping pill use (hazard ratio (HR): 0.469, 95% CI = 0.289–0.760; p-value = 0.002). The cumulative incidence of dementia was lower among CHM users (long-rank test, p-value < 0.001). Association rule mining and network analysis showed that Ye-Jiao-Teng (YJT; Caulis Polygoni Multiflori; Polygonum multiflorum Thunb), Suan-Zao-Ren-Tang (SZRT), Jia-Wei-Xiao-Yao-San (JWXYS), He-Huan-Pi (HHP; Cortex Albizziae; Albizia julibrissin Durazz.), and Suan-Zao-Ren (SZR; Semen Zizyphi Spinosae; Ziziphus jujuba Mill.) were important CHMs for patients with sleep disorders in Taiwan.
A comprehensive list of herbal medicines may be useful for the clinical treatment of patients with sleep disorders, and for future scientific investigations into the prevention of dementia in these patients.
[Display omitted]</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>32822822</pmid><doi>10.1016/j.jep.2020.113267</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9334-603X</orcidid></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Association rule mining Chinese herbal medicine Cohort Studies Dementia Dementia - drug therapy Dementia - ethnology Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - therapeutic use Female Humans Longitudinal Studies Male Medicine, Chinese Traditional - methods Middle Aged Network analysis Retrospective Studies Risk Factors Sleep disorders Sleep Wake Disorders - drug therapy Sleep Wake Disorders - ethnology Taiwan - ethnology Treatment Outcome Young Adult |
| title | Effects of Chinese herbal medicines on dementia risk in patients with sleep disorders in Taiwan |
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