The tyrosine kinase SRC of grass carp (Ctenopharyngodon idellus) up-regulates the expression of IFN I by activating TANK binding kinase 1

In response to viral infections, various pattern recognition receptors (PRRs) are activated for the production of type I interferon (IFN I). As a center of these receptor responses, TANK binding kinase-1 (TBK1) activates interferon regulatory factor 3 (IRF3). SRC is a member of Src family kinases (S...

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Veröffentlicht in:	Developmental and comparative immunology 2021-01, Vol.114, p.103834-103834, Article 103834
Hauptverfasser:	Lv, Yangfeng, Deng, Hang, Liu, Yapeng, Chang, Kaile, Du, Hailing, Zhou, Pengcheng, Mao, Huiling, Hu, Chengyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Carp Carps - immunology Cells, Cultured Cloning, Molecular Ctenopharyngodon idella Cytoplasm Deletion mutant Fish Proteins - genetics Fish Proteins - metabolism Grass carp Immune response Immune system Immunity, Innate Immunology Immunoprecipitation Innate immunity Interferon Interferon regulatory factor Interferon regulatory factor 3 Interferon Type I - genetics Interferon Type I - metabolism Kinases Localization Mammals Pattern recognition Pattern recognition receptors Phosphorylation Poly I-C - immunology Polyinosinic:polycytidylic acid Protein Binding Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Protein-tyrosine kinase Receptors Signal Transduction SRC src-Family Kinases - genetics src-Family Kinases - metabolism Stimulation TBK1 Transcriptional Activation Type I IFN Tyrosine Up-Regulation Virus Diseases - immunology Virus Diseases - metabolism Zebrafish Proteins - genetics
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