Loss of tyrosine hydroxylase, motor deficits and elevated iron in a mouse model of phospholipase A2G6-associated neurodegeneration (PLAN)

•Mouse model of phospholipase A2G6-associated neurodegeneration (PLAN).•PLAN mice displayed body tremors and diminished wire hang performance.•PLAN mice had reduced tyrosine hydroxylase but no neuronal loss in substantia nigra.•PLAN mice had spheroid neuropathology and iron accumulation in the subst...

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Veröffentlicht in:	Brain research 2020-12, Vol.1748, p.147066-147066, Article 147066
Hauptverfasser:	Minkley, Michael, MacLeod, Patrick, Anderson, Christopher K., Nashmi, Raad, Walter, Patrick B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Iron Mice NBIA Neurodegeneration Neurodegeneration with brain iron accumulation Phospholipase A2G6-associated neurodegeneration PLAN Substantia nigra
Online-Zugang:	Volltext
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