Pancreatic volume does not correlate with histologic fibrosis in adult patients with recurrent acute and chronic pancreatitis
Reduced pancreatic volume, often referred to as atrophy, is a commonly reported imaging feature of chronic pancreatitis (CP). This study evaluated whether there is an association between pancreatic volume and fibrosis, the criterion standard of CP, in patients undergoing total pancreatectomy with is...
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| Veröffentlicht in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2020-09, Vol.20 (6), p.1078-1084 |
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| creator | Faghih, Mahya Noë, Michaël Mannan, Rifat Kamel, Ihab R. Zaheer, Atif Kalyani, Rita R. Hall, Erica Afghani, Elham Warren, Daniel Desai, Niraj Sun, Zhaoli Walsh, Christi Makary, Martin A. Goggins, Michael Hruban, Ralph H. He, Jin Singh, Vikesh K. |
| description | Reduced pancreatic volume, often referred to as atrophy, is a commonly reported imaging feature of chronic pancreatitis (CP). This study evaluated whether there is an association between pancreatic volume and fibrosis, the criterion standard of CP, in patients undergoing total pancreatectomy with islet autotransplantation (TPIAT) for recurrent acute pancreatitis (RAP) and CP.
All adult patients who underwent TPIAT between 2010 and 2019 were categorized into 3 groups: RAP, definite CP and indeterminate CP. Pancreatic volume was calculated by summing up the areas from each thin section of the pancreas on 3D CT imaging. Excisional biopsies of the pancreatic head as well as body/tail region were obtained at the time of TPIAT. Two different fibrosis scores were used for histologic assessment.
A total of 16, 29 and 15 patients underwent TPIAT for RAP, definite CP and indeterminate CP, respectively. The mean pancreatic volumes for patients with RAP, definite CP and indeterminate CP were 65.7 ± 28.5 cc, 54.9 ± 22.9 cc and 61.8 ± 23.6 cc, respectively (p = 0.3). The mean fibrosis scores were significantly higher in patients with definite CP compared to RAP (p |
| doi_str_mv | 10.1016/j.pan.2020.07.409 |
| format | Article |
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All adult patients who underwent TPIAT between 2010 and 2019 were categorized into 3 groups: RAP, definite CP and indeterminate CP. Pancreatic volume was calculated by summing up the areas from each thin section of the pancreas on 3D CT imaging. Excisional biopsies of the pancreatic head as well as body/tail region were obtained at the time of TPIAT. Two different fibrosis scores were used for histologic assessment.
A total of 16, 29 and 15 patients underwent TPIAT for RAP, definite CP and indeterminate CP, respectively. The mean pancreatic volumes for patients with RAP, definite CP and indeterminate CP were 65.7 ± 28.5 cc, 54.9 ± 22.9 cc and 61.8 ± 23.6 cc, respectively (p = 0.3). The mean fibrosis scores were significantly higher in patients with definite CP compared to RAP (p < 0.001) and indeterminate CP (p < 0.001). Pancreatic volume was not associated with either fibrosis score after adjusting for age, gender, duration of disease, BMI and diabetes in the multivariable analysis.
While the fibrosis scores were higher in definite CP compared to both RAP and indeterminate CP, there was no correlation between pancreatic volume and fibrosis. This suggests that atrophy alone cannot be used to diagnose CP.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2020.07.409</identifier><language>eng</language><publisher>Philadelphia: Elsevier B.V</publisher><subject>Abdomen ; Age ; Atrophy ; Automation ; Biopsy ; Chronic pancreatitis ; Computed tomography ; Diabetes ; Diabetes mellitus ; Endoscopy ; Etiology ; Fibrosis ; Glucose ; Histopathology ; Medical imaging ; Pain ; Pancreas ; Pancreatic atrophy ; Pancreatic volume ; Pancreatitis ; Recurrent acute pancreatitis ; Software ; Surgery ; TPIAT ; Variables ; Variance analysis ; Veins & arteries</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020-09, Vol.20 (6), p.1078-1084</ispartof><rights>2020</rights><rights>Copyright Elsevier Limited Sep 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-10cb317418dbde4059ee28dd450fbda4122fc93205d22a15b21bf8b448c02ff43</citedby><cites>FETCH-LOGICAL-c358t-10cb317418dbde4059ee28dd450fbda4122fc93205d22a15b21bf8b448c02ff43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Faghih, Mahya</creatorcontrib><creatorcontrib>Noë, Michaël</creatorcontrib><creatorcontrib>Mannan, Rifat</creatorcontrib><creatorcontrib>Kamel, Ihab R.</creatorcontrib><creatorcontrib>Zaheer, Atif</creatorcontrib><creatorcontrib>Kalyani, Rita R.</creatorcontrib><creatorcontrib>Hall, Erica</creatorcontrib><creatorcontrib>Afghani, Elham</creatorcontrib><creatorcontrib>Warren, Daniel</creatorcontrib><creatorcontrib>Desai, Niraj</creatorcontrib><creatorcontrib>Sun, Zhaoli</creatorcontrib><creatorcontrib>Walsh, Christi</creatorcontrib><creatorcontrib>Makary, Martin A.</creatorcontrib><creatorcontrib>Goggins, Michael</creatorcontrib><creatorcontrib>Hruban, Ralph H.</creatorcontrib><creatorcontrib>He, Jin</creatorcontrib><creatorcontrib>Singh, Vikesh K.</creatorcontrib><title>Pancreatic volume does not correlate with histologic fibrosis in adult patients with recurrent acute and chronic pancreatitis</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><description>Reduced pancreatic volume, often referred to as atrophy, is a commonly reported imaging feature of chronic pancreatitis (CP). This study evaluated whether there is an association between pancreatic volume and fibrosis, the criterion standard of CP, in patients undergoing total pancreatectomy with islet autotransplantation (TPIAT) for recurrent acute pancreatitis (RAP) and CP.
All adult patients who underwent TPIAT between 2010 and 2019 were categorized into 3 groups: RAP, definite CP and indeterminate CP. Pancreatic volume was calculated by summing up the areas from each thin section of the pancreas on 3D CT imaging. Excisional biopsies of the pancreatic head as well as body/tail region were obtained at the time of TPIAT. Two different fibrosis scores were used for histologic assessment.
A total of 16, 29 and 15 patients underwent TPIAT for RAP, definite CP and indeterminate CP, respectively. The mean pancreatic volumes for patients with RAP, definite CP and indeterminate CP were 65.7 ± 28.5 cc, 54.9 ± 22.9 cc and 61.8 ± 23.6 cc, respectively (p = 0.3). The mean fibrosis scores were significantly higher in patients with definite CP compared to RAP (p < 0.001) and indeterminate CP (p < 0.001). Pancreatic volume was not associated with either fibrosis score after adjusting for age, gender, duration of disease, BMI and diabetes in the multivariable analysis.
While the fibrosis scores were higher in definite CP compared to both RAP and indeterminate CP, there was no correlation between pancreatic volume and fibrosis. This suggests that atrophy alone cannot be used to diagnose CP.</description><subject>Abdomen</subject><subject>Age</subject><subject>Atrophy</subject><subject>Automation</subject><subject>Biopsy</subject><subject>Chronic pancreatitis</subject><subject>Computed tomography</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Endoscopy</subject><subject>Etiology</subject><subject>Fibrosis</subject><subject>Glucose</subject><subject>Histopathology</subject><subject>Medical imaging</subject><subject>Pain</subject><subject>Pancreas</subject><subject>Pancreatic atrophy</subject><subject>Pancreatic volume</subject><subject>Pancreatitis</subject><subject>Recurrent acute pancreatitis</subject><subject>Software</subject><subject>Surgery</subject><subject>TPIAT</subject><subject>Variables</subject><subject>Variance analysis</subject><subject>Veins & arteries</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kbtOBCEUhidGE68PYEdiY7Mjh4s7EytjvCUmWmhNGDjjspmFERiNhe8uZtXCwgqK7ztw_r-qDoHWQOH0ZFmP2teMMlrTeS1ou1HtgGBixluAzd875dvVbkpLShkDaHeqjwftTUSdnSGvYZhWSGzARHzIxIQYcdAZyZvLC7JwKYchPBeyd10MySXiPNF2GjIZywT0Oa3RiGYqrs9Em6n42ltiFjH44o4_D2aX9qutXg8JD77Pverp6vLx4mZ2d399e3F-NzNcNnkG1HQc5gIa21kUVLaIrLFWSNp3VgtgrDctZ1RaxjTIjkHXN50QjaGs7wXfq47Xc8cYXiZMWa1cMjgM2mOYkmKCn_JWCi4LevQHXYYp-vK7QgmQkkHTFgrWlCk5pIi9GqNb6fiugKqvQtRSlUXVVyGKzlUppDhnawfLpq8Oo0qmZGbQupJXVja4f-xPir2VmQ</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Faghih, Mahya</creator><creator>Noë, Michaël</creator><creator>Mannan, Rifat</creator><creator>Kamel, Ihab R.</creator><creator>Zaheer, Atif</creator><creator>Kalyani, Rita R.</creator><creator>Hall, Erica</creator><creator>Afghani, Elham</creator><creator>Warren, Daniel</creator><creator>Desai, Niraj</creator><creator>Sun, Zhaoli</creator><creator>Walsh, Christi</creator><creator>Makary, Martin A.</creator><creator>Goggins, Michael</creator><creator>Hruban, Ralph H.</creator><creator>He, Jin</creator><creator>Singh, Vikesh K.</creator><general>Elsevier B.V</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Pancreatic volume does not correlate with histologic fibrosis in adult patients with recurrent acute and chronic pancreatitis</title><author>Faghih, Mahya ; Noë, Michaël ; Mannan, Rifat ; Kamel, Ihab R. ; Zaheer, Atif ; Kalyani, Rita R. ; Hall, Erica ; Afghani, Elham ; Warren, Daniel ; Desai, Niraj ; Sun, Zhaoli ; Walsh, Christi ; Makary, Martin A. ; Goggins, Michael ; Hruban, Ralph H. ; He, Jin ; Singh, Vikesh K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-10cb317418dbde4059ee28dd450fbda4122fc93205d22a15b21bf8b448c02ff43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abdomen</topic><topic>Age</topic><topic>Atrophy</topic><topic>Automation</topic><topic>Biopsy</topic><topic>Chronic pancreatitis</topic><topic>Computed tomography</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Endoscopy</topic><topic>Etiology</topic><topic>Fibrosis</topic><topic>Glucose</topic><topic>Histopathology</topic><topic>Medical imaging</topic><topic>Pain</topic><topic>Pancreas</topic><topic>Pancreatic atrophy</topic><topic>Pancreatic volume</topic><topic>Pancreatitis</topic><topic>Recurrent acute pancreatitis</topic><topic>Software</topic><topic>Surgery</topic><topic>TPIAT</topic><topic>Variables</topic><topic>Variance analysis</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Faghih, Mahya</creatorcontrib><creatorcontrib>Noë, Michaël</creatorcontrib><creatorcontrib>Mannan, Rifat</creatorcontrib><creatorcontrib>Kamel, Ihab R.</creatorcontrib><creatorcontrib>Zaheer, Atif</creatorcontrib><creatorcontrib>Kalyani, Rita R.</creatorcontrib><creatorcontrib>Hall, Erica</creatorcontrib><creatorcontrib>Afghani, Elham</creatorcontrib><creatorcontrib>Warren, Daniel</creatorcontrib><creatorcontrib>Desai, Niraj</creatorcontrib><creatorcontrib>Sun, Zhaoli</creatorcontrib><creatorcontrib>Walsh, Christi</creatorcontrib><creatorcontrib>Makary, Martin A.</creatorcontrib><creatorcontrib>Goggins, Michael</creatorcontrib><creatorcontrib>Hruban, Ralph H.</creatorcontrib><creatorcontrib>He, Jin</creatorcontrib><creatorcontrib>Singh, Vikesh K.</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Faghih, Mahya</au><au>Noë, Michaël</au><au>Mannan, Rifat</au><au>Kamel, Ihab R.</au><au>Zaheer, Atif</au><au>Kalyani, Rita R.</au><au>Hall, Erica</au><au>Afghani, Elham</au><au>Warren, Daniel</au><au>Desai, Niraj</au><au>Sun, Zhaoli</au><au>Walsh, Christi</au><au>Makary, Martin A.</au><au>Goggins, Michael</au><au>Hruban, Ralph H.</au><au>He, Jin</au><au>Singh, Vikesh K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pancreatic volume does not correlate with histologic fibrosis in adult patients with recurrent acute and chronic pancreatitis</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><date>2020-09</date><risdate>2020</risdate><volume>20</volume><issue>6</issue><spage>1078</spage><epage>1084</epage><pages>1078-1084</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Reduced pancreatic volume, often referred to as atrophy, is a commonly reported imaging feature of chronic pancreatitis (CP). This study evaluated whether there is an association between pancreatic volume and fibrosis, the criterion standard of CP, in patients undergoing total pancreatectomy with islet autotransplantation (TPIAT) for recurrent acute pancreatitis (RAP) and CP.
All adult patients who underwent TPIAT between 2010 and 2019 were categorized into 3 groups: RAP, definite CP and indeterminate CP. Pancreatic volume was calculated by summing up the areas from each thin section of the pancreas on 3D CT imaging. Excisional biopsies of the pancreatic head as well as body/tail region were obtained at the time of TPIAT. Two different fibrosis scores were used for histologic assessment.
A total of 16, 29 and 15 patients underwent TPIAT for RAP, definite CP and indeterminate CP, respectively. The mean pancreatic volumes for patients with RAP, definite CP and indeterminate CP were 65.7 ± 28.5 cc, 54.9 ± 22.9 cc and 61.8 ± 23.6 cc, respectively (p = 0.3). The mean fibrosis scores were significantly higher in patients with definite CP compared to RAP (p < 0.001) and indeterminate CP (p < 0.001). Pancreatic volume was not associated with either fibrosis score after adjusting for age, gender, duration of disease, BMI and diabetes in the multivariable analysis.
While the fibrosis scores were higher in definite CP compared to both RAP and indeterminate CP, there was no correlation between pancreatic volume and fibrosis. This suggests that atrophy alone cannot be used to diagnose CP.</abstract><cop>Philadelphia</cop><pub>Elsevier B.V</pub><doi>10.1016/j.pan.2020.07.409</doi><tpages>7</tpages></addata></record> |
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| ispartof | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2020-09, Vol.20 (6), p.1078-1084 |
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| source | Alma/SFX Local Collection |
| subjects | Abdomen Age Atrophy Automation Biopsy Chronic pancreatitis Computed tomography Diabetes Diabetes mellitus Endoscopy Etiology Fibrosis Glucose Histopathology Medical imaging Pain Pancreas Pancreatic atrophy Pancreatic volume Pancreatitis Recurrent acute pancreatitis Software Surgery TPIAT Variables Variance analysis Veins & arteries |
| title | Pancreatic volume does not correlate with histologic fibrosis in adult patients with recurrent acute and chronic pancreatitis |
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