CAIX Regulates GBM Motility and TAM Adhesion and Polarization through EGFR/STAT3 under Hypoxic Conditions

Carbonic anhydrases (CAs) are acid-base regulatory proteins that modulate a variety of physiological functions. Recent findings have shown that CAIX is particularly upregulated in glioblastoma multiforme (GBM) and is associated with a poor patient outcome and survival rate. An analysis of the GSE429...

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Veröffentlicht in:	International journal of molecular sciences 2020-08, Vol.21 (16), p.5838, Article 5838
Hauptverfasser:	Huang, Bor-Ren, Liu, Yu-Shu, Lai, Sheng-Wei, Lin, Hui-Jung, Shen, Ching-Kai, Yang, Liang-Yo, Lu, Dah-Yuu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Acids Adhesion Biochemistry & Molecular Biology Brain cancer Brain Neoplasms - enzymology Brain Neoplasms - pathology Breast cancer CAIX (carbonic anhydrase IX) Cancer therapies Carbon dioxide Carbonic Anhydrase IX - metabolism Cell Adhesion Cell growth Cell Line, Tumor Cell Movement Cell Polarity Chemistry Chemistry, Multidisciplinary Chemotherapy Cytotoxicity Datasets Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - metabolism GBM (glioblastoma multiforme) Gene expression Glioblastoma Glioblastoma - enzymology Glioblastoma - pathology Growth factors Humans Hydrogen-Ion Concentration Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factor 1a Hypoxia-inducible factors hypoxic condition Kinases Life Sciences & Biomedicine M2 polarization Macrophages Medical prognosis Metabolism Metabolites Monocytes Monocytes - pathology Motility Pancreatic cancer Physical Sciences Physiology Polarization Protein expression Proteins Regulatory proteins Science & Technology Stat3 protein STAT3 Transcription Factor - metabolism Transcription Tumor Hypoxia Tumor Microenvironment Tumor-Associated Macrophages - enzymology Tumor-Associated Macrophages - pathology Tumors Vascular endothelial growth factor
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