Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis
Eight coumarin derivatives ( ) obtained from natural (-)-mammea A/BB ( ) and 13 synthetic coumarins ( ) had their cytotoxicity and biological activity evaluated against H Rv reference strain and multidrug-resistant clinical isolates. Anti- activity was evaluated by resazurin microtiter assay plate,...
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| Veröffentlicht in: | Future medicinal chemistry 2020-09, Vol.12 (17), p.1533-1546 |
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| container_title | Future medicinal chemistry |
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| creator | Pires, Claudia Ta Scodro, Regiane Bl Cortez, Diógenes Ag Brenzan, Mislaine A Siqueira, Vera Ld Caleffi-Ferracioli, Katiany R Vieira, Lucas Cc Monteiro, Júlia L Corrêa, Arlene G Cardoso, Rosilene F |
| description | Eight coumarin derivatives (
) obtained from natural (-)-mammea A/BB (
) and 13 synthetic coumarins (
) had their cytotoxicity and biological activity evaluated against
H
Rv reference strain and multidrug-resistant clinical isolates.
Anti-
activity was evaluated by resazurin microtiter assay plate, and the cytotoxicity of natural and synthetic products using J774A.1 macrophages by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.
Compounds
,
,
,
and
were more active against
H
Rv and multidrug-resistant clinical isolates with MIC values ranging from 15.6 to 62.5 μg/ml.
These results demonstrate that the coumarin derivatives were active against multidrug-resistant clinical isolates, becoming potential candidates to be used in the treatment of resistant tuberculosis. |
| doi_str_mv | 10.4155/fmc-2018-0281 |
| format | Article |
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) obtained from natural (-)-mammea A/BB (
) and 13 synthetic coumarins (
) had their cytotoxicity and biological activity evaluated against
H
Rv reference strain and multidrug-resistant clinical isolates.
Anti-
activity was evaluated by resazurin microtiter assay plate, and the cytotoxicity of natural and synthetic products using J774A.1 macrophages by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.
Compounds
,
,
,
and
were more active against
H
Rv and multidrug-resistant clinical isolates with MIC values ranging from 15.6 to 62.5 μg/ml.
These results demonstrate that the coumarin derivatives were active against multidrug-resistant clinical isolates, becoming potential candidates to be used in the treatment of resistant tuberculosis.</description><identifier>ISSN: 1756-8919</identifier><identifier>EISSN: 1756-8927</identifier><identifier>DOI: 10.4155/fmc-2018-0281</identifier><identifier>PMID: 32820960</identifier><language>eng</language><publisher>England: Newlands Press</publisher><subject>Anticoagulants ; Biological activity ; Chromatography ; Clinical isolates ; Coumarin ; Cytotoxicity ; Drugs ; Macrophages ; Multidrug resistance ; Mycobacterium tuberculosis ; Solvents ; Tuberculosis</subject><ispartof>Future medicinal chemistry, 2020-09, Vol.12 (17), p.1533-1546</ispartof><rights>Copyright Newlands Press Sep 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c280t-70f4c74c3eba8682eb734280557011435758a7baef99a4dbc08cff83eea2978c3</citedby><cites>FETCH-LOGICAL-c280t-70f4c74c3eba8682eb734280557011435758a7baef99a4dbc08cff83eea2978c3</cites><orcidid>0000-0002-1138-9117 ; 0000-0001-6228-4780 ; 0000-0002-0279-4348 ; 0000-0002-9129-2445 ; 0000-0002-2389-9907 ; 0000-0001-5059-5936 ; 0000-0001-7973-4098 ; 0000-0003-4247-2228 ; 0000-0003-0345-1600</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32820960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pires, Claudia Ta</creatorcontrib><creatorcontrib>Scodro, Regiane Bl</creatorcontrib><creatorcontrib>Cortez, Diógenes Ag</creatorcontrib><creatorcontrib>Brenzan, Mislaine A</creatorcontrib><creatorcontrib>Siqueira, Vera Ld</creatorcontrib><creatorcontrib>Caleffi-Ferracioli, Katiany R</creatorcontrib><creatorcontrib>Vieira, Lucas Cc</creatorcontrib><creatorcontrib>Monteiro, Júlia L</creatorcontrib><creatorcontrib>Corrêa, Arlene G</creatorcontrib><creatorcontrib>Cardoso, Rosilene F</creatorcontrib><title>Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis</title><title>Future medicinal chemistry</title><addtitle>Future Med Chem</addtitle><description>Eight coumarin derivatives (
) obtained from natural (-)-mammea A/BB (
) and 13 synthetic coumarins (
) had their cytotoxicity and biological activity evaluated against
H
Rv reference strain and multidrug-resistant clinical isolates.
Anti-
activity was evaluated by resazurin microtiter assay plate, and the cytotoxicity of natural and synthetic products using J774A.1 macrophages by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.
Compounds
,
,
,
and
were more active against
H
Rv and multidrug-resistant clinical isolates with MIC values ranging from 15.6 to 62.5 μg/ml.
These results demonstrate that the coumarin derivatives were active against multidrug-resistant clinical isolates, becoming potential candidates to be used in the treatment of resistant tuberculosis.</description><subject>Anticoagulants</subject><subject>Biological activity</subject><subject>Chromatography</subject><subject>Clinical isolates</subject><subject>Coumarin</subject><subject>Cytotoxicity</subject><subject>Drugs</subject><subject>Macrophages</subject><subject>Multidrug resistance</subject><subject>Mycobacterium tuberculosis</subject><subject>Solvents</subject><subject>Tuberculosis</subject><issn>1756-8919</issn><issn>1756-8927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkUlLBDEQhYMoKurRqwS8eGnN0ukkRxE3UDyo55DOVGukuzNmGZh_bwaXg3WpgvfVo6iH0DEl5y0V4mKYXMMIVQ1him6hfSpF1yjN5PbfTPUeOkrpg9TiTOlO7KK9OjCiO7KPls85FpdLhMa67Fc-r3GE0WYf5vTulzgMeLZVtyO28wKn9ZzfIXuHXSiTjX7GC4h-VRdWkLB9s35OGT-uXeirYZXKhHPpIboyhuTTIdoZ7Jjg6KcfoNeb65eru-bh6fb-6vKhcUyR3EgytE62jkNvVacY9JK3VRFCEkpbLqRQVvYWBq1tu-gdUW4YFAewTEvl-AE6-_ZdxvBZIGUz-eRgHO0MoSTDWt5xTWXLK3r6D_0IJc71OsOEUJQIrnWlmm_KxZBShMEso68fWBtKzCYNU9MwmzTMJo3Kn_y4ln6CxR_9-3v-Bajxh8E</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Pires, Claudia Ta</creator><creator>Scodro, Regiane Bl</creator><creator>Cortez, Diógenes Ag</creator><creator>Brenzan, Mislaine A</creator><creator>Siqueira, Vera Ld</creator><creator>Caleffi-Ferracioli, Katiany R</creator><creator>Vieira, Lucas Cc</creator><creator>Monteiro, Júlia L</creator><creator>Corrêa, Arlene G</creator><creator>Cardoso, Rosilene F</creator><general>Newlands Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1138-9117</orcidid><orcidid>https://orcid.org/0000-0001-6228-4780</orcidid><orcidid>https://orcid.org/0000-0002-0279-4348</orcidid><orcidid>https://orcid.org/0000-0002-9129-2445</orcidid><orcidid>https://orcid.org/0000-0002-2389-9907</orcidid><orcidid>https://orcid.org/0000-0001-5059-5936</orcidid><orcidid>https://orcid.org/0000-0001-7973-4098</orcidid><orcidid>https://orcid.org/0000-0003-4247-2228</orcidid><orcidid>https://orcid.org/0000-0003-0345-1600</orcidid></search><sort><creationdate>202009</creationdate><title>Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis</title><author>Pires, Claudia Ta ; Scodro, Regiane Bl ; Cortez, Diógenes Ag ; Brenzan, Mislaine A ; Siqueira, Vera Ld ; Caleffi-Ferracioli, Katiany R ; Vieira, Lucas Cc ; Monteiro, Júlia L ; Corrêa, Arlene G ; Cardoso, Rosilene F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c280t-70f4c74c3eba8682eb734280557011435758a7baef99a4dbc08cff83eea2978c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anticoagulants</topic><topic>Biological activity</topic><topic>Chromatography</topic><topic>Clinical isolates</topic><topic>Coumarin</topic><topic>Cytotoxicity</topic><topic>Drugs</topic><topic>Macrophages</topic><topic>Multidrug resistance</topic><topic>Mycobacterium tuberculosis</topic><topic>Solvents</topic><topic>Tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pires, Claudia Ta</creatorcontrib><creatorcontrib>Scodro, Regiane Bl</creatorcontrib><creatorcontrib>Cortez, Diógenes Ag</creatorcontrib><creatorcontrib>Brenzan, Mislaine A</creatorcontrib><creatorcontrib>Siqueira, Vera Ld</creatorcontrib><creatorcontrib>Caleffi-Ferracioli, Katiany R</creatorcontrib><creatorcontrib>Vieira, Lucas Cc</creatorcontrib><creatorcontrib>Monteiro, Júlia L</creatorcontrib><creatorcontrib>Corrêa, Arlene G</creatorcontrib><creatorcontrib>Cardoso, Rosilene F</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Future medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pires, Claudia Ta</au><au>Scodro, Regiane Bl</au><au>Cortez, Diógenes Ag</au><au>Brenzan, Mislaine A</au><au>Siqueira, Vera Ld</au><au>Caleffi-Ferracioli, Katiany R</au><au>Vieira, Lucas Cc</au><au>Monteiro, Júlia L</au><au>Corrêa, Arlene G</au><au>Cardoso, Rosilene F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis</atitle><jtitle>Future medicinal chemistry</jtitle><addtitle>Future Med Chem</addtitle><date>2020-09</date><risdate>2020</risdate><volume>12</volume><issue>17</issue><spage>1533</spage><epage>1546</epage><pages>1533-1546</pages><issn>1756-8919</issn><eissn>1756-8927</eissn><abstract>Eight coumarin derivatives (
) obtained from natural (-)-mammea A/BB (
) and 13 synthetic coumarins (
) had their cytotoxicity and biological activity evaluated against
H
Rv reference strain and multidrug-resistant clinical isolates.
Anti-
activity was evaluated by resazurin microtiter assay plate, and the cytotoxicity of natural and synthetic products using J774A.1 macrophages by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.
Compounds
,
,
,
and
were more active against
H
Rv and multidrug-resistant clinical isolates with MIC values ranging from 15.6 to 62.5 μg/ml.
These results demonstrate that the coumarin derivatives were active against multidrug-resistant clinical isolates, becoming potential candidates to be used in the treatment of resistant tuberculosis.</abstract><cop>England</cop><pub>Newlands Press</pub><pmid>32820960</pmid><doi>10.4155/fmc-2018-0281</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-1138-9117</orcidid><orcidid>https://orcid.org/0000-0001-6228-4780</orcidid><orcidid>https://orcid.org/0000-0002-0279-4348</orcidid><orcidid>https://orcid.org/0000-0002-9129-2445</orcidid><orcidid>https://orcid.org/0000-0002-2389-9907</orcidid><orcidid>https://orcid.org/0000-0001-5059-5936</orcidid><orcidid>https://orcid.org/0000-0001-7973-4098</orcidid><orcidid>https://orcid.org/0000-0003-4247-2228</orcidid><orcidid>https://orcid.org/0000-0003-0345-1600</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1756-8919 |
| ispartof | Future medicinal chemistry, 2020-09, Vol.12 (17), p.1533-1546 |
| issn | 1756-8919 1756-8927 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2436391743 |
| source | PubMed Central |
| subjects | Anticoagulants Biological activity Chromatography Clinical isolates Coumarin Cytotoxicity Drugs Macrophages Multidrug resistance Mycobacterium tuberculosis Solvents Tuberculosis |
| title | Structure-activity relationship of natural and synthetic coumarin derivatives against Mycobacterium tuberculosis |
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