Appropriate thresholds for accurate screening for β-thalassemias in the newborn period: results from a French center for newborn screening

Newborn screening (NBS) for β-thalassemia is based on measuring the expression of the hemoglobin A (HbA) fraction. An absence or very low level of HbA at birth may indicate β-thalassemia. The difficulty is that the HbA fraction at birth is correlated with gestational age (GA) and highly variable bet...

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Veröffentlicht in:	Clinical chemistry and laboratory medicine 2021-01, Vol.59 (1), p.209-216
Hauptverfasser:	Allaf, Bichr, Pondarre, Corinne, Allali, Slimane, De Montalembert, Mariane, Arnaud, Cécile, Barrey, Catherine, Benkerrou, Malika, Benhaim, Patricia, Bensaid, Philippe, Brousse, Valentine, Dollfus, Catherine, Eyssette-Guerreau, Stéphanie, Galacteros, Frédéric, Gajdos, Vincent, Garrec, Nathalie, Guillaumat, Cécile, Guitton, Corinne, Monfort-Gouraud, Marie, Gouraud, François, Holvoet, Laurent, Ithier, Ghislaine, Kamdem, Annie, Koehl, Bérengère, Malric, Aurore, Missud, Florence, Monier, Brigitte, Odièvre, Marie-Hélène, Joly, Philippe, Renoux, Céline, Patin, Franck, Pissard, Serge, Couque, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	anemia Birth cutoff Evaluation Gestational age Hemoglobin hemoglobin A Low level Medical screening multiple of median Neonates newborn screening Public health Reliability analysis Sickle cell disease Thalassemia Thresholds β-thalassemia
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