Bone marrow coagulated and low‐level laser therapy accelerate bone healing by enhancing angiogenesis, cell proliferation, osteoblast differentiation, and mineralization

The present study evaluated bone marrow aspirate (BMA) and low‐level laser therapy (LLLT) on bone healing. It was created critical‐size defects (CSD) of 5 mm diameter in rat calvaria of 64 rats. Animals were randomly divided into four groups: Control (blood clot), BMA (coagulated BMA), LLLT (laser i...

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Veröffentlicht in:	Journal of biomedical materials research. Part A 2021-06, Vol.109 (6), p.849-858
Hauptverfasser:	Santinoni, Carolina S., Neves, Adrieli P. C., Almeida, Breno F. M., Kajimoto, Natália C., Pola, Natália M., Caliente, Eliana A., Belem, Eduarda L. G., Lelis, Joilson B., Fucini, Stephen E., Messora, Michel R., Garcia, Valdir G., Bomfim, Suely R. M., Ervolino, Edilson, Nagata, Maria J. H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antigens Biomarkers - analysis Biomedical materials Blood Blood clots Blood Coagulation Bone healing Bone Marrow Bone morphogenetic proteins bone regeneration Bone Regeneration - drug effects Bone Regeneration - radiation effects Calcification, Physiologic - drug effects Calcification, Physiologic - radiation effects Calvaria Cbfa-1 protein Cell differentiation Cell Differentiation - drug effects Cell proliferation Cell Proliferation - drug effects Cell Proliferation - radiation effects Euthanasia Fracture Healing Growth factors Healing immunohistochemistry Irradiation Laser Therapy - methods Lasers low‐level laser therapy Male Mesenchymal stem cells Mineralization Neovascularization, Physiologic - drug effects Neovascularization, Physiologic - radiation effects Osteoblastogenesis Osteoblasts - drug effects Osteoblasts - radiation effects Osteocalcin Osteopontin Proliferating cell nuclear antigen Rats Rats, Wistar Vascular endothelial growth factor
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