Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains

Interactome maps are valuable resources to elucidate protein function and disease mechanisms. Here, we report on an interactome map that focuses on neurodegenerative disease (ND), connects ∼5,000 human proteins via ∼30,000 candidate interactions and is generated by systematic yeast two-hybrid intera...

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Veröffentlicht in:	Cell reports (Cambridge) 2020-08, Vol.32 (7), p.108050-108050, Article 108050
Hauptverfasser:	Haenig, Christian, Atias, Nir, Taylor, Alexander K., Mazza, Arnon, Schaefer, Martin H., Russ, Jenny, Riechers, Sean-Patrick, Jain, Shushant, Coughlin, Maura, Fontaine, Jean-Fred, Freibaum, Brian D., Brusendorf, Lydia, Zenkner, Martina, Porras, Pablo, Stroedicke, Martin, Schnoegl, Sigrid, Arnsburg, Kristin, Boeddrich, Annett, Pigazzini, Lucia, Heutink, Peter, Taylor, J. Paul, Kirstein, Janine, Andrade-Navarro, Miguel A., Sharan, Roded, Wanker, Erich E.
Format:	Artikel
Sprache:	eng
Schlagworte:	aggregation modulators ARF-GEP100 disease network modules disease-causing proteins neurodegenerative diseases PPI validation protein aggregation protein-protein interactions TDP-43 yeast-two-hybrid
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