Longitudinal associations between metabolic score for visceral fat and hyperuricemia in non-obese adults

The assessment of visceral adiposity is of great significance for the prevention of hyperuricemia (HUA), especially in non-obese individuals. The metabolic score for visceral fat (METS-VF) is a newly proposed surrogate of visceral obesity. We aimed to evaluate the longitudinal associations of METS-VF with the risk of HUA in non-obese adults. A total of 16,058 non-obese adults without HUA were included for this retrospective cohort analyses. The crude incidence rate of HUA in non-obese women and men were 20.9 and 69.6 per 1000 person-years, respectively. The Cox proportional hazards model indicated that METS-VF was significantly associated with the risk of HUA in both genders. Whereas, METS-VF only had the highest HR in women, but not in men. METS-VF, a novel surrogate of visceral adiposity combined biochemical and anthropometric parameters, age, and gender, could be a useful tool for the hierarchical prevention and management of HUA among non-obese women. •Obesity is a well-established risk factor of hyperuricemia (HUA).•HUA is also common in non-obese people who may exist visceral obesity.•Metabolic score for visceral fat (METS-VF) was associated with the increased risk of HUA in lean individuals.•METS-VF is potential monitor in the prevention of HUA among lean people.