Metabolomics on serum levels and liver of male Tupaia belangeri from 12 locations in China by GC–MS
Objectives To investigate adaptive strategies of Tupaia belangeri to environmental factors in different populations, 12 locations were selected, including higher and lower altitude areas. Results Total of 96 and 90 metabolites were annotated in serum and liver respectively, which were mainly concent...
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| Veröffentlicht in: | Biotechnology letters 2020-12, Vol.42 (12), p.2561-2567 |
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| creator | Hou, Dongmin Jia, Ting Zhang, Di Gao, Wenrong Zhu, Wanlong Wang, Zhengkun |
| description | Objectives
To investigate adaptive strategies of
Tupaia belangeri
to environmental factors in different populations, 12 locations were selected, including higher and lower altitude areas.
Results
Total of 96 and 90 metabolites were annotated in serum and liver respectively, which were mainly concentrated in primary metabolites. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) showed that the locations were divided into two groups in serum metabolites, but each group had a few samples overlap. The samples of each group overlap to some degree in the liver metabolites. The tricarboxylic acid (TCA) cycle occupies a central position in metabolism. The concentrations of TCA intermediates, lipid metabolites and amino acid metabolites were higher in higher altitude areas, and the concentrations of carbohydrate and glycolysis intermediates were higher in lower altitude areas.
Conclusions
Different areas adapted to the changes of environmental and altitude by regulating the concentration of metabolites in serum and liver, and revealed the adaptive mechanism of
T. belangeri
in different living environments. |
| doi_str_mv | 10.1007/s10529-020-02988-w |
| format | Article |
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To investigate adaptive strategies of
Tupaia belangeri
to environmental factors in different populations, 12 locations were selected, including higher and lower altitude areas.
Results
Total of 96 and 90 metabolites were annotated in serum and liver respectively, which were mainly concentrated in primary metabolites. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) showed that the locations were divided into two groups in serum metabolites, but each group had a few samples overlap. The samples of each group overlap to some degree in the liver metabolites. The tricarboxylic acid (TCA) cycle occupies a central position in metabolism. The concentrations of TCA intermediates, lipid metabolites and amino acid metabolites were higher in higher altitude areas, and the concentrations of carbohydrate and glycolysis intermediates were higher in lower altitude areas.
Conclusions
Different areas adapted to the changes of environmental and altitude by regulating the concentration of metabolites in serum and liver, and revealed the adaptive mechanism of
T. belangeri
in different living environments.</description><identifier>ISSN: 0141-5492</identifier><identifier>EISSN: 1573-6776</identifier><identifier>DOI: 10.1007/s10529-020-02988-w</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Altitude ; Amino acids ; Applied Microbiology ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Carbohydrates ; Discriminant analysis ; Environmental changes ; Environmental factors ; Glycolysis ; Intermediates ; Life Sciences ; Lipid metabolism ; Lipids ; Liver ; Metabolites ; Metabolomics ; Microbiology ; Original Research Paper ; Principal components analysis ; Serum levels ; Tricarboxylic acid cycle ; Tupaia belangeri</subject><ispartof>Biotechnology letters, 2020-12, Vol.42 (12), p.2561-2567</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-db23da179afbf9d6bf5ab87e7ea26e295fced46dff3ee07946cd707ab76e38333</citedby><cites>FETCH-LOGICAL-c389t-db23da179afbf9d6bf5ab87e7ea26e295fced46dff3ee07946cd707ab76e38333</cites><orcidid>0000-0001-8261-4089</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10529-020-02988-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10529-020-02988-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Hou, Dongmin</creatorcontrib><creatorcontrib>Jia, Ting</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Gao, Wenrong</creatorcontrib><creatorcontrib>Zhu, Wanlong</creatorcontrib><creatorcontrib>Wang, Zhengkun</creatorcontrib><title>Metabolomics on serum levels and liver of male Tupaia belangeri from 12 locations in China by GC–MS</title><title>Biotechnology letters</title><addtitle>Biotechnol Lett</addtitle><description>Objectives
To investigate adaptive strategies of
Tupaia belangeri
to environmental factors in different populations, 12 locations were selected, including higher and lower altitude areas.
Results
Total of 96 and 90 metabolites were annotated in serum and liver respectively, which were mainly concentrated in primary metabolites. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) showed that the locations were divided into two groups in serum metabolites, but each group had a few samples overlap. The samples of each group overlap to some degree in the liver metabolites. The tricarboxylic acid (TCA) cycle occupies a central position in metabolism. The concentrations of TCA intermediates, lipid metabolites and amino acid metabolites were higher in higher altitude areas, and the concentrations of carbohydrate and glycolysis intermediates were higher in lower altitude areas.
Conclusions
Different areas adapted to the changes of environmental and altitude by regulating the concentration of metabolites in serum and liver, and revealed the adaptive mechanism of
T. belangeri
in different living environments.</description><subject>Altitude</subject><subject>Amino acids</subject><subject>Applied Microbiology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Carbohydrates</subject><subject>Discriminant analysis</subject><subject>Environmental changes</subject><subject>Environmental factors</subject><subject>Glycolysis</subject><subject>Intermediates</subject><subject>Life Sciences</subject><subject>Lipid metabolism</subject><subject>Lipids</subject><subject>Liver</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Microbiology</subject><subject>Original Research Paper</subject><subject>Principal components analysis</subject><subject>Serum levels</subject><subject>Tricarboxylic acid cycle</subject><subject>Tupaia belangeri</subject><issn>0141-5492</issn><issn>1573-6776</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kLtKBTEQhoMoeLy8gFXAxmY1l02yKeXgDRQLtQ7Z3YlGsptjclax8x18Q5_E6BEEC4thmu__mfkQ2qPkkBKijjIlgumKMFJGN031soZmVCheSaXkOpoRWtNK1Jptoq2cHwkhWhE1Q3AFS9vGEAffZRxHnCFNAw7wDCFjO_Y4-GdIODo82AD4dlpYb3ELwY73kDx2KQ6YMhxiZ5c-jhn7Ec8f_FigV3w2_3h7v7rZQRvOhgy7P3sb3Z2e3M7Pq8vrs4v58WXV8UYvq75lvLdUaetap3vZOmHbRoECyyQwLVwHfS175zgAUbqWXV--sK2SwBvO-TY6WPUuUnyaIC_N4HMHoRwLccqG1VwITkQtCrr_B32MUxrLdYVSVAqqpSwUW1FdijkncGaR_GDTq6HEfJk3K_OmmDff5s1LCfFVKBf4y9Jv9T-pT1mRh_E</recordid><startdate>20201201</startdate><enddate>20201201</enddate><creator>Hou, Dongmin</creator><creator>Jia, Ting</creator><creator>Zhang, Di</creator><creator>Gao, Wenrong</creator><creator>Zhu, Wanlong</creator><creator>Wang, Zhengkun</creator><general>Springer Netherlands</general><general>Springer Nature 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metabolism</topic><topic>Lipids</topic><topic>Liver</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Microbiology</topic><topic>Original Research Paper</topic><topic>Principal components analysis</topic><topic>Serum levels</topic><topic>Tricarboxylic acid cycle</topic><topic>Tupaia belangeri</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hou, Dongmin</creatorcontrib><creatorcontrib>Jia, Ting</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Gao, Wenrong</creatorcontrib><creatorcontrib>Zhu, Wanlong</creatorcontrib><creatorcontrib>Wang, Zhengkun</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Mechanical & Transportation Engineering 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Wanlong</au><au>Wang, Zhengkun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolomics on serum levels and liver of male Tupaia belangeri from 12 locations in China by GC–MS</atitle><jtitle>Biotechnology letters</jtitle><stitle>Biotechnol Lett</stitle><date>2020-12-01</date><risdate>2020</risdate><volume>42</volume><issue>12</issue><spage>2561</spage><epage>2567</epage><pages>2561-2567</pages><issn>0141-5492</issn><eissn>1573-6776</eissn><abstract>Objectives
To investigate adaptive strategies of
Tupaia belangeri
to environmental factors in different populations, 12 locations were selected, including higher and lower altitude areas.
Results
Total of 96 and 90 metabolites were annotated in serum and liver respectively, which were mainly concentrated in primary metabolites. Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) showed that the locations were divided into two groups in serum metabolites, but each group had a few samples overlap. The samples of each group overlap to some degree in the liver metabolites. The tricarboxylic acid (TCA) cycle occupies a central position in metabolism. The concentrations of TCA intermediates, lipid metabolites and amino acid metabolites were higher in higher altitude areas, and the concentrations of carbohydrate and glycolysis intermediates were higher in lower altitude areas.
Conclusions
Different areas adapted to the changes of environmental and altitude by regulating the concentration of metabolites in serum and liver, and revealed the adaptive mechanism of
T. belangeri
in different living environments.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><doi>10.1007/s10529-020-02988-w</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8261-4089</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Altitude Amino acids Applied Microbiology Biochemistry Biomedical and Life Sciences Biotechnology Carbohydrates Discriminant analysis Environmental changes Environmental factors Glycolysis Intermediates Life Sciences Lipid metabolism Lipids Liver Metabolites Metabolomics Microbiology Original Research Paper Principal components analysis Serum levels Tricarboxylic acid cycle Tupaia belangeri |
| title | Metabolomics on serum levels and liver of male Tupaia belangeri from 12 locations in China by GC–MS |
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