S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants

After birth, the immune system matures via interactions with microbes in the gut. The S100 calcium binding proteins S100A8 and S100A9, and their extracellular complex form, S100A8–A9, are found in high amounts in human breast milk. We studied levels of S100A8–A9 in fecal samples (also called fecal c...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2020-12, Vol.159 (6), p.2130-2145.e5
Hauptverfasser:	Willers, Maike, Ulas, Thomas, Völlger, Lena, Vogl, Thomas, Heinemann, Anna S., Pirr, Sabine, Pagel, Julia, Fehlhaber, Beate, Halle, Olga, Schöning, Jennifer, Schreek, Sabine, Löber, Ulrike, Essex, Morgan, Hombach, Peter, Graspeuntner, Simon, Basic, Marijana, Bleich, Andre, Cloppenborg-Schmidt, Katja, Künzel, Sven, Jonigk, Danny, Rupp, Jan, Hansen, Gesine, Förster, Reinhold, Baines, John F., Härtel, Christoph, Schultze, Joachim L., Forslund, Sofia K., Roth, Johannes, Viemann, Dorothee
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Biopsy BMI Calgranulin A - administration & dosage Calgranulin A - analysis Calgranulin A - metabolism Calgranulin B - analysis Calgranulin B - genetics Calgranulin B - metabolism Child, Preschool Colon - microbiology Colon - pathology DNA, Bacterial - genetics DNA, Bacterial - isolation & purification Dysbiosis - immunology Dysbiosis - microbiology Dysbiosis - prevention & control Enterocolitis, Necrotizing - epidemiology Enterocolitis, Necrotizing - immunology Enterocolitis, Necrotizing - microbiology Enterocolitis, Necrotizing - prevention & control Feces - chemistry Feces - microbiology Female Follow-Up Studies Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - immunology Gut Mucosal Immunity Humans Immunity, Mucosal Infant Infant, Newborn Infant, Premature - immunology Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Male Mice Mice, Knockout NEC Obesity - epidemiology Obesity - immunology Obesity - microbiology Obesity - prevention & control RNA, Ribosomal, 16S - genetics Sepsis - epidemiology Sepsis - immunology Sepsis - microbiology Sepsis - prevention & control Treg Cells
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