Rapid Access to Tetracyclic Core of Wortmannin via an Intramolecular Reductive Olefin Coupling Strategy

A convergent approach to assemble the fused BCDE tetracyclic framework of wortmannin is presented. This route features a very challenging Suzuki–Miyaura coupling to prepare the fully functionalized furan intermediate, a Negishi-type acylation to unite the two enantio-enriched fragments, and a subseq...

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Veröffentlicht in:	Organic letters 2020-08, Vol.22 (16), p.6308-6312
Hauptverfasser:	Hu, Ying, Bai, Miao, Yang, Ying, Tian, Jiangyan, Zhou, Qianghui
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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