A dynamic COVID-19 immune signature includes associations with poor prognosis

Improved understanding and management of COVID-19, a potentially life-threatening disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward this end, we have identified a core peripheral blood immune signature across 63 hospital-treated patients with COVID-19 who were...

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Veröffentlicht in:	Nature medicine 2020-10, Vol.26 (10), p.1623-1635
Hauptverfasser:	Laing, Adam G., Lorenc, Anna, del Molino del Barrio, Irene, Das, Abhishek, Fish, Matthew, Monin, Leticia, Muñoz-Ruiz, Miguel, McKenzie, Duncan R., Hayday, Thomas S., Francos-Quijorna, Isaac, Kamdar, Shraddha, Joseph, Magdalene, Davies, Daniel, Davis, Richard, Jennings, Aislinn, Zlatareva, Iva, Vantourout, Pierre, Wu, Yin, Sofra, Vasiliki, Cano, Florencia, Greco, Maria, Theodoridis, Efstathios, Freedman, Joshua D., Gee, Sarah, Chan, Julie Nuo En, Ryan, Sarah, Bugallo-Blanco, Eva, Peterson, Pärt, Kisand, Kai, Haljasmägi, Liis, Chadli, Loubna, Moingeon, Philippe, Martinez, Lauren, Merrick, Blair, Bisnauthsing, Karen, Brooks, Kate, Ibrahim, Mohammad A. A., Mason, Jeremy, Lopez Gomez, Federico, Babalola, Kola, Abdul-Jawad, Sultan, Cason, John, Mant, Christine, Seow, Jeffrey, Graham, Carl, Doores, Katie J., Di Rosa, Francesca, Edgeworth, Jonathan, Shankar-Hari, Manu, Hayday, Adrian C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/254 692/699/255/2514 Aged Antibodies Antibodies, Viral - immunology B-Lymphocyte Subsets - immunology B-Lymphocytes - immunology Basophils - immunology Betacoronavirus Biomedical and Life Sciences Biomedicine Blood Cancer Research Case-Control Studies Cell Cycle Chemokine CXCL10 - immunology Chemokines Chemokines - immunology Cohort Studies Coronavirus Infections - blood Coronavirus Infections - immunology Coronaviruses COVID-19 Cytokines Cytokines - immunology Dendritic cells Dendritic Cells - immunology Depletion Disease Disease Progression Etiology Female Flow Cytometry Health aspects Hospitalization Humans Immune response Immunologic Memory Immunophenotyping Infectious Diseases Interleukin 10 Interleukin 6 Interleukin-10 - immunology Interleukin-6 - immunology IP-10 protein Leukocyte Count Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Male Metabolic Diseases Middle Aged Molecular Medicine Neurosciences Pandemics Pathogenesis Patients Peripheral blood Phenotypes Pneumonia, Viral - blood Pneumonia, Viral - immunology Prognosis SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index T-Lymphocyte Subsets - immunology T-Lymphocytes - immunology Up-Regulation
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