Epigenomic analysis of Parkinson’s disease neurons identifies Tet2 loss as neuroprotective

Parkinson’s disease (PD) pathogenesis may involve the epigenetic control of enhancers that modify neuronal functions. Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of patients with PD and of control individuals. We find a widespread increase in cytosine modif...

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Veröffentlicht in:	Nature neuroscience 2020-10, Vol.23 (10), p.1203-1214
Hauptverfasser:	Marshall, Lee L., Killinger, Bryan A., Ensink, Elizabeth, Li, Peipei, Li, Katie X., Cui, Wei, Lubben, Noah, Weiland, Matthew, Wang, Xinhe, Gordevicius, Juozas, Coetzee, Gerhard A., Ma, Jiyan, Jovinge, Stefan, Labrie, Viviane
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 13/51 45 45/23 45/91 631/208/176 631/378/1689/1718 64/60 Animal Genetics and Genomics Animals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell Line, Tumor Cytosine Deactivation Dioxygenases DNA Methylation DNA-Binding Proteins - genetics Dopamine receptors Enhancers Epigenesis, Genetic Epigenetics Epigenomics Female Gene Expression Regulation Genomes Humans Immune response Inactivation Inflammation Male Mice, Inbred C57BL Mice, Knockout Movement disorders Neurobiology Neurodegenerative diseases Neurons Neurons - metabolism Neuroprotection Neurosciences Parkinson Disease - genetics Parkinson's disease Pathogenesis Prefrontal Cortex - metabolism Proto-Oncogene Proteins - genetics Substantia nigra Therapeutic targets Up-regulation
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