Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice

Cenpj is a centrosomal protein located at the centrosomes and the base of cilia, it plays essential roles in regulating neurogenesis and cerebral cortex development. Although centrosomal and cilium dysfunction are one of the causes of obesity, insulin resistance, and type 2 diabetes, the role that C...

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Veröffentlicht in:	Science China. Life sciences 2021-03, Vol.64 (3), p.419-433
Hauptverfasser:	Ding, Wenyu, Zhang, Changjiang, Wang, Baisong, Zhou, Xin, Sun, Le, Zhong, Suijuan, Liu, Jing, Zhang, Junjing, Wang, Xiaoqun, Wu, Qian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Arcuate nucleus Biomedical and Life Sciences Body weight Cell Line Cell Proliferation Centrosomes Cerebral cortex Cilia Diabetes mellitus (non-insulin dependent) Embryos Gene Knockdown Techniques Hypothalamus Hypothalamus - embryology Hypothalamus - metabolism Hypothalamus - physiopathology Insulin Insulin resistance Life Sciences Melanocortin Melanocortin MC4 receptors Mice Microtubule-Associated Proteins - genetics Neurogenesis Neurons - metabolism Neuropeptide Y Obesity Obesity, Morbid - genetics Obesity, Morbid - physiopathology Paraventricular nucleus Pro-Opiomelanocortin - metabolism Proopiomelanocortin Proteins Receptor, Melanocortin, Type 4 - metabolism Research Paper Thyroid Nuclear Factor 1 - genetics Thyroid transcription factor 1
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