Evaluation of DNA-binding and DNA-photocleavage ability of tetra-cationic porphyrins containing peripheral [Ru(bpy)2Cl]+ complexes: Insights for photodynamic therapy agents

The present work reports the spectroscopic and theoretical evaluation of the interaction between calf-thymus DNA (CT-DNA) and free-base meso-tetra-(ruthenated) porphyrin (H2RuTPyP) or its corresponding Zn(II) complex (ZnRuTPyP). Spectroscopic measurements (UV–vis, circular dichroism and steady-state...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2020-10, Vol.211, p.111991-111991, Article 111991
Hauptverfasser:	Oliveira, Vanessa A., Terenzi, Hernán, Menezes, Lucas B., Chaves, Otávio A., Iglesias, Bernardo A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cationic porphyrins Cations - chemistry Circular dichroism Coordination Complexes - chemistry Coordination Complexes - pharmacology Deoxyribonucleic acid Dichroism DNA DNA - radiation effects DNA Cleavage - radiation effects DNA-binding Electrophoresis Electrostatic properties Evaluation Fluorescence Free Radical Scavengers - chemistry Gel electrophoresis Irradiation Light Light irradiation Molecular docking Molecular Docking Simulation Photochemotherapy Photocleavage assays Photodynamic therapy Photodynamic therapy (PDT) Photosensitizing Agents - chemistry Photosensitizing Agents - pharmacology Porphyrins Porphyrins - chemistry Reactive Oxygen Species - chemistry Ruthenium - chemistry Static Electricity Structure-Activity Relationship Tetra-ruthenated porphyrins White light Zinc - chemistry
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