Outcomes after anomalous aortic origin of a coronary artery repair: A Congenital Heart Surgeons’ Society Study
It remains unclear when sudden cardiac event risk outweighs surgical risk for patients with anomalous aortic origin of a coronary artery. The Congenital Heart Surgeons' Society sought to characterize the surgical risks by determining the techniques, complications, and outcomes of repair. Betwee...
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| Veröffentlicht in: | The Journal of thoracic and cardiovascular surgery 2020-09, Vol.160 (3), p.757-771.e5 |
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| creator | Jegatheeswaran, Anusha Devlin, Paul J. Williams, William G. Brothers, Julie A. Jacobs, Marshall L. DeCampli, William M. Fleishman, Craig E. Kirklin, James K. Mertens, Luc Mery, Carlos M. Molossi, Silvana Caldarone, Christopher A. Aghaei, Nabi Lorber, Richard O. McCrindle, Brian W. |
| description | It remains unclear when sudden cardiac event risk outweighs surgical risk for patients with anomalous aortic origin of a coronary artery. The Congenital Heart Surgeons' Society sought to characterize the surgical risks by determining the techniques, complications, and outcomes of repair.
Between January 2000 and September 2018, 682 patients with anomalous aortic origin of a coronary artery aged 30 years or less were enrolled. Demographic, morphologic, operative, imaging, and ischemia-related data were analyzed.
There were 395 of 682 (57%) surgical patients (45 centers, median follow-up 2.8 years). In addition to primary repair (87% unroofing, 26% commissural manipulation), 13 patients had 15 coronary-related reoperations. Of 358 patients with pre/postoperative aortic insufficiency assessment, 27 (8%) developed new mild or greater aortic insufficiency postoperatively, and 7 (2%) developed new moderate or greater aortic insufficiency. Freedom from mild aortic insufficiency differed in those with versus without commissural manipulation (85%/91% at 6 months, 83%/90% at 1 year, and 77%/88% at 3 years, respectively) (P = .05). Of 347 patients with preoperative/postoperative ejection fraction, 6 (2%) developed new abnormal ejection fraction ( |
| doi_str_mv | 10.1016/j.jtcvs.2020.01.114 |
| format | Article |
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Between January 2000 and September 2018, 682 patients with anomalous aortic origin of a coronary artery aged 30 years or less were enrolled. Demographic, morphologic, operative, imaging, and ischemia-related data were analyzed.
There were 395 of 682 (57%) surgical patients (45 centers, median follow-up 2.8 years). In addition to primary repair (87% unroofing, 26% commissural manipulation), 13 patients had 15 coronary-related reoperations. Of 358 patients with pre/postoperative aortic insufficiency assessment, 27 (8%) developed new mild or greater aortic insufficiency postoperatively, and 7 (2%) developed new moderate or greater aortic insufficiency. Freedom from mild aortic insufficiency differed in those with versus without commissural manipulation (85%/91% at 6 months, 83%/90% at 1 year, and 77%/88% at 3 years, respectively) (P = .05). Of 347 patients with preoperative/postoperative ejection fraction, 6 (2%) developed new abnormal ejection fraction (<50%) within 30 days of surgery which persisted. Although 64 of 395 patients (16%) had preoperative ischemia, after surgery 51 of 64 patients (80%) no longer had ischemia (13 = new postoperative ischemia, P < .0001). Four patients died postoperatively (preoperatively 2 asymptomatic, 1 symptomatic, 1 in extremis). Composite surgical adverse event rates were 7% to 13% in the entire cohort (increasing/decreasing by presentation/anatomy/repair strategy).
Anomalous aortic origin of a coronary artery surgery may relieve ischemia with low mortality; however, it can result in a variety of important morbidities, varying by the group evaluated. Strategies avoiding commissural manipulation may decrease the risk of developing aortic insufficiency. Understanding these risks should inform surgical decision-making and support the need for standardized assessment and management.
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Between January 2000 and September 2018, 682 patients with anomalous aortic origin of a coronary artery aged 30 years or less were enrolled. Demographic, morphologic, operative, imaging, and ischemia-related data were analyzed.
There were 395 of 682 (57%) surgical patients (45 centers, median follow-up 2.8 years). In addition to primary repair (87% unroofing, 26% commissural manipulation), 13 patients had 15 coronary-related reoperations. Of 358 patients with pre/postoperative aortic insufficiency assessment, 27 (8%) developed new mild or greater aortic insufficiency postoperatively, and 7 (2%) developed new moderate or greater aortic insufficiency. Freedom from mild aortic insufficiency differed in those with versus without commissural manipulation (85%/91% at 6 months, 83%/90% at 1 year, and 77%/88% at 3 years, respectively) (P = .05). Of 347 patients with preoperative/postoperative ejection fraction, 6 (2%) developed new abnormal ejection fraction (<50%) within 30 days of surgery which persisted. Although 64 of 395 patients (16%) had preoperative ischemia, after surgery 51 of 64 patients (80%) no longer had ischemia (13 = new postoperative ischemia, P < .0001). Four patients died postoperatively (preoperatively 2 asymptomatic, 1 symptomatic, 1 in extremis). Composite surgical adverse event rates were 7% to 13% in the entire cohort (increasing/decreasing by presentation/anatomy/repair strategy).
Anomalous aortic origin of a coronary artery surgery may relieve ischemia with low mortality; however, it can result in a variety of important morbidities, varying by the group evaluated. Strategies avoiding commissural manipulation may decrease the risk of developing aortic insufficiency. Understanding these risks should inform surgical decision-making and support the need for standardized assessment and management.
[Display omitted]</description><subject>anomalous aortic origin of a coronary artery</subject><subject>complications</subject><subject>congenital heart disease</subject><subject>epidemiology</subject><subject>surgery</subject><issn>0022-5223</issn><issn>1097-685X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kMFKAzEQhoMoWKtP4CVHL7tONtndVvBQilqh0EMVvIVsdrak7G5qkhV68zV8PZ_E1Hr2NAzz_wPfR8g1g5QBK2636TboD59mkEEKLGVMnJARg2mZFJP87ZSMALIsybOMn5ML77cAUAKbjshuNQRtO_RUNQEdVb3tVGuHuFsXjKbWmY3pqW2ooto62yu3p8rF7J463Cnj7uiMzm2_wd4E1dIFxitdD26Dtvffn190bbXBsKfrMNT7S3LWqNbj1d8ck9fHh5f5Ilmunp7ns2WiOS9CUlVc5I1oGK9rlufAc62LcgJFXgnNlZ5mvAbGmeIFVwq1qqpSTGrOoBZVUXE-JjfHvztn3wf0QXbGa2xb1WPEk5ngosyZgEOUH6PaWe8dNnLnTBc5JQN58Cu38tevPPiVwGT0G1v3xxZGig-DTvqI2WusjUMdZG3Nv_0fxheHYQ</recordid><startdate>202009</startdate><enddate>202009</enddate><creator>Jegatheeswaran, Anusha</creator><creator>Devlin, Paul J.</creator><creator>Williams, William G.</creator><creator>Brothers, Julie A.</creator><creator>Jacobs, Marshall L.</creator><creator>DeCampli, William M.</creator><creator>Fleishman, Craig E.</creator><creator>Kirklin, James K.</creator><creator>Mertens, Luc</creator><creator>Mery, Carlos M.</creator><creator>Molossi, Silvana</creator><creator>Caldarone, Christopher A.</creator><creator>Aghaei, Nabi</creator><creator>Lorber, Richard O.</creator><creator>McCrindle, Brian W.</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202009</creationdate><title>Outcomes after anomalous aortic origin of a coronary artery repair: A Congenital Heart Surgeons’ Society Study</title><author>Jegatheeswaran, Anusha ; Devlin, Paul J. ; Williams, William G. ; Brothers, Julie A. ; Jacobs, Marshall L. ; DeCampli, William M. ; Fleishman, Craig E. ; Kirklin, James K. ; Mertens, Luc ; Mery, Carlos M. ; Molossi, Silvana ; Caldarone, Christopher A. ; Aghaei, Nabi ; Lorber, Richard O. ; McCrindle, Brian W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-bb345f4f13dd155035cc678065b4c3ac923d0131a363aaecabb748d310d4b6b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>anomalous aortic origin of a coronary artery</topic><topic>complications</topic><topic>congenital heart disease</topic><topic>epidemiology</topic><topic>surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jegatheeswaran, Anusha</creatorcontrib><creatorcontrib>Devlin, Paul J.</creatorcontrib><creatorcontrib>Williams, William G.</creatorcontrib><creatorcontrib>Brothers, Julie A.</creatorcontrib><creatorcontrib>Jacobs, Marshall L.</creatorcontrib><creatorcontrib>DeCampli, William M.</creatorcontrib><creatorcontrib>Fleishman, Craig E.</creatorcontrib><creatorcontrib>Kirklin, James K.</creatorcontrib><creatorcontrib>Mertens, Luc</creatorcontrib><creatorcontrib>Mery, Carlos M.</creatorcontrib><creatorcontrib>Molossi, Silvana</creatorcontrib><creatorcontrib>Caldarone, Christopher A.</creatorcontrib><creatorcontrib>Aghaei, Nabi</creatorcontrib><creatorcontrib>Lorber, Richard O.</creatorcontrib><creatorcontrib>McCrindle, Brian W.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jegatheeswaran, Anusha</au><au>Devlin, Paul J.</au><au>Williams, William G.</au><au>Brothers, Julie A.</au><au>Jacobs, Marshall L.</au><au>DeCampli, William M.</au><au>Fleishman, Craig E.</au><au>Kirklin, James K.</au><au>Mertens, Luc</au><au>Mery, Carlos M.</au><au>Molossi, Silvana</au><au>Caldarone, Christopher A.</au><au>Aghaei, Nabi</au><au>Lorber, Richard O.</au><au>McCrindle, Brian W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcomes after anomalous aortic origin of a coronary artery repair: A Congenital Heart Surgeons’ Society Study</atitle><jtitle>The Journal of thoracic and cardiovascular surgery</jtitle><date>2020-09</date><risdate>2020</risdate><volume>160</volume><issue>3</issue><spage>757</spage><epage>771.e5</epage><pages>757-771.e5</pages><issn>0022-5223</issn><eissn>1097-685X</eissn><abstract>It remains unclear when sudden cardiac event risk outweighs surgical risk for patients with anomalous aortic origin of a coronary artery. The Congenital Heart Surgeons' Society sought to characterize the surgical risks by determining the techniques, complications, and outcomes of repair.
Between January 2000 and September 2018, 682 patients with anomalous aortic origin of a coronary artery aged 30 years or less were enrolled. Demographic, morphologic, operative, imaging, and ischemia-related data were analyzed.
There were 395 of 682 (57%) surgical patients (45 centers, median follow-up 2.8 years). In addition to primary repair (87% unroofing, 26% commissural manipulation), 13 patients had 15 coronary-related reoperations. Of 358 patients with pre/postoperative aortic insufficiency assessment, 27 (8%) developed new mild or greater aortic insufficiency postoperatively, and 7 (2%) developed new moderate or greater aortic insufficiency. Freedom from mild aortic insufficiency differed in those with versus without commissural manipulation (85%/91% at 6 months, 83%/90% at 1 year, and 77%/88% at 3 years, respectively) (P = .05). Of 347 patients with preoperative/postoperative ejection fraction, 6 (2%) developed new abnormal ejection fraction (<50%) within 30 days of surgery which persisted. Although 64 of 395 patients (16%) had preoperative ischemia, after surgery 51 of 64 patients (80%) no longer had ischemia (13 = new postoperative ischemia, P < .0001). Four patients died postoperatively (preoperatively 2 asymptomatic, 1 symptomatic, 1 in extremis). Composite surgical adverse event rates were 7% to 13% in the entire cohort (increasing/decreasing by presentation/anatomy/repair strategy).
Anomalous aortic origin of a coronary artery surgery may relieve ischemia with low mortality; however, it can result in a variety of important morbidities, varying by the group evaluated. Strategies avoiding commissural manipulation may decrease the risk of developing aortic insufficiency. Understanding these risks should inform surgical decision-making and support the need for standardized assessment and management.
[Display omitted]</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.jtcvs.2020.01.114</doi></addata></record> |
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| ispartof | The Journal of thoracic and cardiovascular surgery, 2020-09, Vol.160 (3), p.757-771.e5 |
| issn | 0022-5223 1097-685X |
| language | eng |
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| source | Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | anomalous aortic origin of a coronary artery complications congenital heart disease epidemiology surgery |
| title | Outcomes after anomalous aortic origin of a coronary artery repair: A Congenital Heart Surgeons’ Society Study |
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