Effects of interleukin-6 and tumor necrosis factor-α on the expression of angiogenic and collagenolytic factors in premature and mature adipocytes

The remodeling of the vascular network and collagen in the extracellular matrix is closely associated with the expansion and dysfunction of adipose tissue. In the present study, we investigated the effects of interleukin (IL)-6 and tumor necrosis factor (TNF)-α on the expression of angiogenic factor...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-10, Vol.531 (3), p.297-304
Hauptverfasser:	Shibata, Chika, Nakai, Kumiko, Ozaki, Manami, Koshi, Ryosuke, Tanaka, Hideki, Morita, Toyoko, Maeno, Masao, Kawato, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes Adipocytes - drug effects Adipocytes - enzymology Adipocytes - metabolism Angiogenic factors Animals Cell Differentiation - drug effects Collagen Type I - genetics Collagen Type I - metabolism Collagenolytic factors Culture Media, Conditioned - pharmacology Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Interleukin-6 Interleukin-6 - pharmacology Matrix Metalloproteinase 13 - metabolism Mice Neovascularization, Physiologic - drug effects RNA, Messenger - genetics RNA, Messenger - metabolism Tissue Inhibitor of Metalloproteinase-1 - metabolism Tumor Necrosis Factor-alpha - pharmacology Tumor necrosis factor-α
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