Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk
Elevated lipoprotein(a) (Lp[a]) and family history (FHx) of coronary heart disease (CHD) are individually associated with cardiovascular risk, and Lp(a) is commonly measured in those with FHx. The aim of this study was to determine independent and joint associations of Lp(a) and FHx with atheroscler...
Gespeichert in:
| Veröffentlicht in: | Journal of the American College of Cardiology 2020-08, Vol.76 (7), p.781-793 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 793 |
|---|---|
| container_issue | 7 |
| container_start_page | 781 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 76 |
| creator | Mehta, Anurag Virani, Salim S Ayers, Colby R Sun, Wensheng Hoogeveen, Ron C Rohatgi, Anand Berry, Jarett D Joshi, Parag H Ballantyne, Christie M Khera, Amit |
| description | Elevated lipoprotein(a) (Lp[a]) and family history (FHx) of coronary heart disease (CHD) are individually associated with cardiovascular risk, and Lp(a) is commonly measured in those with FHx.
The aim of this study was to determine independent and joint associations of Lp(a) and FHx with atherosclerotic cardiovascular disease (ASCVD) and CHD among asymptomatic subjects.
Plasma Lp(a) was measured and FHx was ascertained in 2 cohorts. Elevated Lp(a) was defined as the highest race-specific quintile. Independent and joint associations of Lp(a) and FHx with cardiovascular risk were determined using Cox regression models adjusted for cardiovascular risk factors.
Among 12,149 ARIC (Atherosclerosis Risk In Communities) participants (54 years, 56% women, 23% black, 44% with FHx), 3,114 ASCVD events were observed during 21 years of follow-up. FHx and elevated Lp(a) were independently associated with ASCVD (hazard ratio [HR]: 1.17; 95% confidence interval [CI]: 1.09 to 1.26, and HR: 1.25; 95% CI: 1.12 to 1.40, respectively), and no Lp(a)-by-FHx interaction was noted (p = 0.75). Compared with subjects without FHx and nonelevated Lp(a), those with either elevated Lp(a) or FHx were at a higher ASCVD risk, while those with both had the highest risk (HR: 1.43; 95% CI: 1.27 to 1.62). Similar findings were observed for CHD risk in ARIC, in analyses stratified by premature FHx, and in an independent cohort, the DHS (Dallas Heart Study). Presence of both elevated Lp(a) and FHx resulted in greater improvement in ASCVD and CHD risk reclassification and discrimination indexes than either marker alone.
Elevated plasma Lp(a) and FHx have independent and additive joint associations with cardiovascular risk and may be useful concurrently for guiding primary prevention therapy decisions. |
| doi_str_mv | 10.1016/j.jacc.2020.06.040 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2434486281</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2434486281</sourcerecordid><originalsourceid>FETCH-LOGICAL-c413t-360dc59c7aa3319196e5b1bdf12e5d35e50382f89d945408e66bd059033a7eed3</originalsourceid><addsrcrecordid>eNo90MFLwzAUBvAgipvTf8CD9DgPrS9JkzZHmZsTBoroOaTJK2R260xaYf-9HZue3uX7Ph4_Qm4pZBSofFhna2NtxoBBBjKDHM7ImApRplyo4pyMoeAipaCKEbmKcQ0AsqTqkow4KxSDQozJfOV37S60Hfrt1NwnZuuShdn4Zp8sfezasE_eAjpvu2RmgvPtj4m2b0xInnxEEzF59_HrmlzUpol4c7oT8rmYf8yW6er1-WX2uEptTnmXcgnOCmULYziniiqJoqKVqylD4bhAAbxkdamcykUOJUpZORAKODcFouMTMj3uDh9_9xg7vfHRYtOYLbZ91CzneV5KVtIhyo5RG9oYA9Z6F_zGhL2moA98eq0PfPrAp0HqgW8o3Z32-2qD7r_y58V_AeZoa00</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2434486281</pqid></control><display><type>article</type><title>Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Mehta, Anurag ; Virani, Salim S ; Ayers, Colby R ; Sun, Wensheng ; Hoogeveen, Ron C ; Rohatgi, Anand ; Berry, Jarett D ; Joshi, Parag H ; Ballantyne, Christie M ; Khera, Amit</creator><creatorcontrib>Mehta, Anurag ; Virani, Salim S ; Ayers, Colby R ; Sun, Wensheng ; Hoogeveen, Ron C ; Rohatgi, Anand ; Berry, Jarett D ; Joshi, Parag H ; Ballantyne, Christie M ; Khera, Amit</creatorcontrib><description>Elevated lipoprotein(a) (Lp[a]) and family history (FHx) of coronary heart disease (CHD) are individually associated with cardiovascular risk, and Lp(a) is commonly measured in those with FHx.
The aim of this study was to determine independent and joint associations of Lp(a) and FHx with atherosclerotic cardiovascular disease (ASCVD) and CHD among asymptomatic subjects.
Plasma Lp(a) was measured and FHx was ascertained in 2 cohorts. Elevated Lp(a) was defined as the highest race-specific quintile. Independent and joint associations of Lp(a) and FHx with cardiovascular risk were determined using Cox regression models adjusted for cardiovascular risk factors.
Among 12,149 ARIC (Atherosclerosis Risk In Communities) participants (54 years, 56% women, 23% black, 44% with FHx), 3,114 ASCVD events were observed during 21 years of follow-up. FHx and elevated Lp(a) were independently associated with ASCVD (hazard ratio [HR]: 1.17; 95% confidence interval [CI]: 1.09 to 1.26, and HR: 1.25; 95% CI: 1.12 to 1.40, respectively), and no Lp(a)-by-FHx interaction was noted (p = 0.75). Compared with subjects without FHx and nonelevated Lp(a), those with either elevated Lp(a) or FHx were at a higher ASCVD risk, while those with both had the highest risk (HR: 1.43; 95% CI: 1.27 to 1.62). Similar findings were observed for CHD risk in ARIC, in analyses stratified by premature FHx, and in an independent cohort, the DHS (Dallas Heart Study). Presence of both elevated Lp(a) and FHx resulted in greater improvement in ASCVD and CHD risk reclassification and discrimination indexes than either marker alone.
Elevated plasma Lp(a) and FHx have independent and additive joint associations with cardiovascular risk and may be useful concurrently for guiding primary prevention therapy decisions.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2020.06.040</identifier><identifier>PMID: 32792075</identifier><language>eng</language><publisher>United States</publisher><subject>Asymptomatic Diseases - epidemiology ; Coronary Disease - blood ; Coronary Disease - diagnosis ; Coronary Disease - epidemiology ; Coronary Disease - prevention & control ; Female ; Heart Disease Risk Factors ; Humans ; Lipoprotein(a) - blood ; Male ; Medical History Taking - methods ; Medical History Taking - statistics & numerical data ; Middle Aged ; Needs Assessment ; Primary Prevention - organization & administration ; United States - epidemiology</subject><ispartof>Journal of the American College of Cardiology, 2020-08, Vol.76 (7), p.781-793</ispartof><rights>Copyright © 2020 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-360dc59c7aa3319196e5b1bdf12e5d35e50382f89d945408e66bd059033a7eed3</citedby><cites>FETCH-LOGICAL-c413t-360dc59c7aa3319196e5b1bdf12e5d35e50382f89d945408e66bd059033a7eed3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32792075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehta, Anurag</creatorcontrib><creatorcontrib>Virani, Salim S</creatorcontrib><creatorcontrib>Ayers, Colby R</creatorcontrib><creatorcontrib>Sun, Wensheng</creatorcontrib><creatorcontrib>Hoogeveen, Ron C</creatorcontrib><creatorcontrib>Rohatgi, Anand</creatorcontrib><creatorcontrib>Berry, Jarett D</creatorcontrib><creatorcontrib>Joshi, Parag H</creatorcontrib><creatorcontrib>Ballantyne, Christie M</creatorcontrib><creatorcontrib>Khera, Amit</creatorcontrib><title>Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Elevated lipoprotein(a) (Lp[a]) and family history (FHx) of coronary heart disease (CHD) are individually associated with cardiovascular risk, and Lp(a) is commonly measured in those with FHx.
The aim of this study was to determine independent and joint associations of Lp(a) and FHx with atherosclerotic cardiovascular disease (ASCVD) and CHD among asymptomatic subjects.
Plasma Lp(a) was measured and FHx was ascertained in 2 cohorts. Elevated Lp(a) was defined as the highest race-specific quintile. Independent and joint associations of Lp(a) and FHx with cardiovascular risk were determined using Cox regression models adjusted for cardiovascular risk factors.
Among 12,149 ARIC (Atherosclerosis Risk In Communities) participants (54 years, 56% women, 23% black, 44% with FHx), 3,114 ASCVD events were observed during 21 years of follow-up. FHx and elevated Lp(a) were independently associated with ASCVD (hazard ratio [HR]: 1.17; 95% confidence interval [CI]: 1.09 to 1.26, and HR: 1.25; 95% CI: 1.12 to 1.40, respectively), and no Lp(a)-by-FHx interaction was noted (p = 0.75). Compared with subjects without FHx and nonelevated Lp(a), those with either elevated Lp(a) or FHx were at a higher ASCVD risk, while those with both had the highest risk (HR: 1.43; 95% CI: 1.27 to 1.62). Similar findings were observed for CHD risk in ARIC, in analyses stratified by premature FHx, and in an independent cohort, the DHS (Dallas Heart Study). Presence of both elevated Lp(a) and FHx resulted in greater improvement in ASCVD and CHD risk reclassification and discrimination indexes than either marker alone.
Elevated plasma Lp(a) and FHx have independent and additive joint associations with cardiovascular risk and may be useful concurrently for guiding primary prevention therapy decisions.</description><subject>Asymptomatic Diseases - epidemiology</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - diagnosis</subject><subject>Coronary Disease - epidemiology</subject><subject>Coronary Disease - prevention & control</subject><subject>Female</subject><subject>Heart Disease Risk Factors</subject><subject>Humans</subject><subject>Lipoprotein(a) - blood</subject><subject>Male</subject><subject>Medical History Taking - methods</subject><subject>Medical History Taking - statistics & numerical data</subject><subject>Middle Aged</subject><subject>Needs Assessment</subject><subject>Primary Prevention - organization & administration</subject><subject>United States - epidemiology</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MFLwzAUBvAgipvTf8CD9DgPrS9JkzZHmZsTBoroOaTJK2R260xaYf-9HZue3uX7Ph4_Qm4pZBSofFhna2NtxoBBBjKDHM7ImApRplyo4pyMoeAipaCKEbmKcQ0AsqTqkow4KxSDQozJfOV37S60Hfrt1NwnZuuShdn4Zp8sfezasE_eAjpvu2RmgvPtj4m2b0xInnxEEzF59_HrmlzUpol4c7oT8rmYf8yW6er1-WX2uEptTnmXcgnOCmULYziniiqJoqKVqylD4bhAAbxkdamcykUOJUpZORAKODcFouMTMj3uDh9_9xg7vfHRYtOYLbZ91CzneV5KVtIhyo5RG9oYA9Z6F_zGhL2moA98eq0PfPrAp0HqgW8o3Z32-2qD7r_y58V_AeZoa00</recordid><startdate>20200818</startdate><enddate>20200818</enddate><creator>Mehta, Anurag</creator><creator>Virani, Salim S</creator><creator>Ayers, Colby R</creator><creator>Sun, Wensheng</creator><creator>Hoogeveen, Ron C</creator><creator>Rohatgi, Anand</creator><creator>Berry, Jarett D</creator><creator>Joshi, Parag H</creator><creator>Ballantyne, Christie M</creator><creator>Khera, Amit</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200818</creationdate><title>Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk</title><author>Mehta, Anurag ; Virani, Salim S ; Ayers, Colby R ; Sun, Wensheng ; Hoogeveen, Ron C ; Rohatgi, Anand ; Berry, Jarett D ; Joshi, Parag H ; Ballantyne, Christie M ; Khera, Amit</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-360dc59c7aa3319196e5b1bdf12e5d35e50382f89d945408e66bd059033a7eed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Asymptomatic Diseases - epidemiology</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - diagnosis</topic><topic>Coronary Disease - epidemiology</topic><topic>Coronary Disease - prevention & control</topic><topic>Female</topic><topic>Heart Disease Risk Factors</topic><topic>Humans</topic><topic>Lipoprotein(a) - blood</topic><topic>Male</topic><topic>Medical History Taking - methods</topic><topic>Medical History Taking - statistics & numerical data</topic><topic>Middle Aged</topic><topic>Needs Assessment</topic><topic>Primary Prevention - organization & administration</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehta, Anurag</creatorcontrib><creatorcontrib>Virani, Salim S</creatorcontrib><creatorcontrib>Ayers, Colby R</creatorcontrib><creatorcontrib>Sun, Wensheng</creatorcontrib><creatorcontrib>Hoogeveen, Ron C</creatorcontrib><creatorcontrib>Rohatgi, Anand</creatorcontrib><creatorcontrib>Berry, Jarett D</creatorcontrib><creatorcontrib>Joshi, Parag H</creatorcontrib><creatorcontrib>Ballantyne, Christie M</creatorcontrib><creatorcontrib>Khera, Amit</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehta, Anurag</au><au>Virani, Salim S</au><au>Ayers, Colby R</au><au>Sun, Wensheng</au><au>Hoogeveen, Ron C</au><au>Rohatgi, Anand</au><au>Berry, Jarett D</au><au>Joshi, Parag H</au><au>Ballantyne, Christie M</au><au>Khera, Amit</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2020-08-18</date><risdate>2020</risdate><volume>76</volume><issue>7</issue><spage>781</spage><epage>793</epage><pages>781-793</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Elevated lipoprotein(a) (Lp[a]) and family history (FHx) of coronary heart disease (CHD) are individually associated with cardiovascular risk, and Lp(a) is commonly measured in those with FHx.
The aim of this study was to determine independent and joint associations of Lp(a) and FHx with atherosclerotic cardiovascular disease (ASCVD) and CHD among asymptomatic subjects.
Plasma Lp(a) was measured and FHx was ascertained in 2 cohorts. Elevated Lp(a) was defined as the highest race-specific quintile. Independent and joint associations of Lp(a) and FHx with cardiovascular risk were determined using Cox regression models adjusted for cardiovascular risk factors.
Among 12,149 ARIC (Atherosclerosis Risk In Communities) participants (54 years, 56% women, 23% black, 44% with FHx), 3,114 ASCVD events were observed during 21 years of follow-up. FHx and elevated Lp(a) were independently associated with ASCVD (hazard ratio [HR]: 1.17; 95% confidence interval [CI]: 1.09 to 1.26, and HR: 1.25; 95% CI: 1.12 to 1.40, respectively), and no Lp(a)-by-FHx interaction was noted (p = 0.75). Compared with subjects without FHx and nonelevated Lp(a), those with either elevated Lp(a) or FHx were at a higher ASCVD risk, while those with both had the highest risk (HR: 1.43; 95% CI: 1.27 to 1.62). Similar findings were observed for CHD risk in ARIC, in analyses stratified by premature FHx, and in an independent cohort, the DHS (Dallas Heart Study). Presence of both elevated Lp(a) and FHx resulted in greater improvement in ASCVD and CHD risk reclassification and discrimination indexes than either marker alone.
Elevated plasma Lp(a) and FHx have independent and additive joint associations with cardiovascular risk and may be useful concurrently for guiding primary prevention therapy decisions.</abstract><cop>United States</cop><pmid>32792075</pmid><doi>10.1016/j.jacc.2020.06.040</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2020-08, Vol.76 (7), p.781-793 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2434486281 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Asymptomatic Diseases - epidemiology Coronary Disease - blood Coronary Disease - diagnosis Coronary Disease - epidemiology Coronary Disease - prevention & control Female Heart Disease Risk Factors Humans Lipoprotein(a) - blood Male Medical History Taking - methods Medical History Taking - statistics & numerical data Middle Aged Needs Assessment Primary Prevention - organization & administration United States - epidemiology |
| title | Lipoprotein(a) and Family History Predict Cardiovascular Disease Risk |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T09%3A12%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lipoprotein(a)%20and%20Family%20History%20Predict%20Cardiovascular%20Disease%20Risk&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=Mehta,%20Anurag&rft.date=2020-08-18&rft.volume=76&rft.issue=7&rft.spage=781&rft.epage=793&rft.pages=781-793&rft.issn=0735-1097&rft.eissn=1558-3597&rft_id=info:doi/10.1016/j.jacc.2020.06.040&rft_dat=%3Cproquest_cross%3E2434486281%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2434486281&rft_id=info:pmid/32792075&rfr_iscdi=true |