The impact of EPA and DHA on ceramide lipotoxicity in the metabolic syndrome

The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors including obesity, insulin resistance (IR) and dyslipidaemia. Consumption of a high-fat diet (HFD) enriched in SFA leads to the accumulation of ceramide (Cer), the central molecule in sphingolipid metabolism. Elevations in pla...

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Veröffentlicht in:	British journal of nutrition 2021-04, Vol.125 (8), p.863-875
Hauptverfasser:	Walchuk, Chelsey, Wang, Yidi, Suh, Miyoung
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiovascular diseases Cell culture Ceramide Diabetes Diet Disease Dyslipidemia Fatty acids Glucose Health risks High fat diet Human and Clinical Nutrition In vivo methods and tests Inflammation Insulin Insulin resistance Kinases Lipid metabolism Lipids Liver Metabolic disorders Metabolic syndrome Musculoskeletal system Obesity Palmitic acid Parameters Pathogenesis Phosphorylation Plasma Proteins Resistance factors Risk analysis Risk factors
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