Identifying mismatch repair‐deficient colon cancer: near‐perfect concordance between immunohistochemistry and microsatellite instability testing in a large, population‐based series

Aims Establishing the mismatch repair (MMR) status of colorectal cancers is important to enable the detection of underlying Lynch syndrome and inform prognosis and therapy. Current testing typically involves either polymerase chain reaction (PCR)‐based microsatellite instability (MSI) testing or MMR...

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Veröffentlicht in:	Histopathology 2021-02, Vol.78 (3), p.401-413
Hauptverfasser:	Loughrey, Maurice B, McGrath, Jason, Coleman, Helen G, Bankhead, Peter, Maxwell, Perry, McGready, Claire, Bingham, Victoria, Humphries, Matthew P, Craig, Stephanie G, McQuaid, Stephen, Salto‐Tellez, Manuel, James, Jacqueline A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cohort Studies Colon - pathology Colon cancer Colonic Neoplasms - diagnosis Colonic Neoplasms - epidemiology Colonic Neoplasms - genetics Colonic Neoplasms - pathology Colorectal cancer Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis Colorectal Neoplasms, Hereditary Nonpolyposis - epidemiology Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Colorectal Neoplasms, Hereditary Nonpolyposis - pathology DNA Mismatch Repair Epithelial cells Female Humans Immunohistochemistry Immunohistochemistry - methods Inflammation Male Microsatellite Instability Middle Aged Mismatch repair MMR protein Polymerase chain reaction Polymerase Chain Reaction - methods Prognosis Sensitivity and Specificity Tumors
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