Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study
Background Gastric cancer (GC) is mostly diagnosed at advanced stage, so prognosis is poor. Therefore, it is necessary to understand the molecular mechanism of GC development to design new targeted treatment to improve the prognosis of gastric cancer patients. Aim of the Work To assess the prognosti...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2021-06, Vol.52 (2), p.728-737 |
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| creator | Elaidy, Noha F. Harb, Ola A. Mohamed, Abdel Motaleb Hemeda, Rehab Taha, Heba F. Samir, Amr Elsayed, Ahmed M. Osman, Gamal Hendawy, Elsayed I El |
| description | Background
Gastric cancer (GC) is mostly diagnosed at advanced stage, so prognosis is poor. Therefore, it is necessary to understand the molecular mechanism of GC development to design new targeted treatment to improve the prognosis of gastric cancer patients.
Aim of the Work
To assess the prognostic value of NEDD-9 and FOXL-1 expression in intestinal type gastric cancer patients, as well as their relationship to clinicopathologic features of the disease and patients outcome.
Patients and Methods
This is a retrospective study; we included 50 sections from formalin-fixed, paraffin-embedded tissue samples which included intestinal type GC and adjacent non-neoplastic gastric mucosa in the same block that were subjected to immunohistochemistry with anti-NEDD-9 and anti-FOXL-1 antibody. Patients were retrospectively followed up for about 5 years for assessment of tumor progression and survival in relation to marker expression.
Results
High NEDD-9 and low FOXL-1 expression were found in intestinal type GC more than adjacent non-neoplastic mucosa (
p
|
| doi_str_mv | 10.1007/s12029-020-00471-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2434484564</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2434484564</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-4d80c1a4948c94337552a9a8fd6fe512a24c4af84897078e20ec9d3dd04561d93</originalsourceid><addsrcrecordid>eNp9kMtKAzEUhoMoXqov4EKydBPNbS5xJ22thaKCCu5CTDI1MpPUZAYsvrzRqktX58D5_p_DB8AxwWcE4-o8EYqpQJhihDGvCGJbYJ8ITlBZsnL7b6f1HjhI6RXjkheE7II9Rqt8wmIffNzFsPQh9U7De7f0rnFaeW0TDA28mU4mSEDlDby6fVogAqfvq2hTcsFD5-Hc9zYnvWrhw3pl4UylPuaisYra-dCpi5yF864bfHhxqQ_6xXa5v4X3_WDWh2CnUW2yRz9zBB6vpg_ja7S4nc3HlwukGa96xE2NNVFc8FoLzlhVFFQJVTembGxBqKJcc9XUvBYVrmpLsdXCMGMwL0piBBuB003vKoa3IX8sO5e0bVvlbRiSpJxxXmeYZ5RuUB1DStE2chVdp-JaEiy_pMuNdJmly2_pkuXQyU__8NxZ8xf5tZwBtgFSPvmljfI1DDFrS__VfgILsYxh</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2434484564</pqid></control><display><type>article</type><title>Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study</title><source>SpringerNature Journals</source><creator>Elaidy, Noha F. ; Harb, Ola A. ; Mohamed, Abdel Motaleb ; Hemeda, Rehab ; Taha, Heba F. ; Samir, Amr ; Elsayed, Ahmed M. ; Osman, Gamal ; Hendawy, Elsayed I El</creator><creatorcontrib>Elaidy, Noha F. ; Harb, Ola A. ; Mohamed, Abdel Motaleb ; Hemeda, Rehab ; Taha, Heba F. ; Samir, Amr ; Elsayed, Ahmed M. ; Osman, Gamal ; Hendawy, Elsayed I El</creatorcontrib><description>Background
Gastric cancer (GC) is mostly diagnosed at advanced stage, so prognosis is poor. Therefore, it is necessary to understand the molecular mechanism of GC development to design new targeted treatment to improve the prognosis of gastric cancer patients.
Aim of the Work
To assess the prognostic value of NEDD-9 and FOXL-1 expression in intestinal type gastric cancer patients, as well as their relationship to clinicopathologic features of the disease and patients outcome.
Patients and Methods
This is a retrospective study; we included 50 sections from formalin-fixed, paraffin-embedded tissue samples which included intestinal type GC and adjacent non-neoplastic gastric mucosa in the same block that were subjected to immunohistochemistry with anti-NEDD-9 and anti-FOXL-1 antibody. Patients were retrospectively followed up for about 5 years for assessment of tumor progression and survival in relation to marker expression.
Results
High NEDD-9 and low FOXL-1 expression were found in intestinal type GC more than adjacent non-neoplastic mucosa (
p
< 0.001). NEDD-9 high expression and FOXL-1 low expression were associated with presence of helicobacter pylori gastritis (
p
= 0.010, 0.049), high grade (
p
= 0.007, 0.004), high stage (
p
< 0.001)
,
presence of distant metastases (
p
= 0.029, 0.021), poor DFS (
p
= 0.003), and OS rates (< 0.001).
Conclusion
NEDD-9 overexpression and FOXL-1 deficiency in intestinal type GC can help in prediction of tumor prognosis and it can guide the selection of patients for future therapies in gastric carcinoma.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-020-00471-3</identifier><identifier>PMID: 32794109</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Gastroenterology ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Radiotherapy</subject><ispartof>Journal of gastrointestinal cancer, 2021-06, Vol.52 (2), p.728-737</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-4d80c1a4948c94337552a9a8fd6fe512a24c4af84897078e20ec9d3dd04561d93</citedby><cites>FETCH-LOGICAL-c347t-4d80c1a4948c94337552a9a8fd6fe512a24c4af84897078e20ec9d3dd04561d93</cites><orcidid>0000-0002-4396-3101</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-020-00471-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-020-00471-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27931,27932,41495,42564,51326</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32794109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elaidy, Noha F.</creatorcontrib><creatorcontrib>Harb, Ola A.</creatorcontrib><creatorcontrib>Mohamed, Abdel Motaleb</creatorcontrib><creatorcontrib>Hemeda, Rehab</creatorcontrib><creatorcontrib>Taha, Heba F.</creatorcontrib><creatorcontrib>Samir, Amr</creatorcontrib><creatorcontrib>Elsayed, Ahmed M.</creatorcontrib><creatorcontrib>Osman, Gamal</creatorcontrib><creatorcontrib>Hendawy, Elsayed I El</creatorcontrib><title>Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Background
Gastric cancer (GC) is mostly diagnosed at advanced stage, so prognosis is poor. Therefore, it is necessary to understand the molecular mechanism of GC development to design new targeted treatment to improve the prognosis of gastric cancer patients.
Aim of the Work
To assess the prognostic value of NEDD-9 and FOXL-1 expression in intestinal type gastric cancer patients, as well as their relationship to clinicopathologic features of the disease and patients outcome.
Patients and Methods
This is a retrospective study; we included 50 sections from formalin-fixed, paraffin-embedded tissue samples which included intestinal type GC and adjacent non-neoplastic gastric mucosa in the same block that were subjected to immunohistochemistry with anti-NEDD-9 and anti-FOXL-1 antibody. Patients were retrospectively followed up for about 5 years for assessment of tumor progression and survival in relation to marker expression.
Results
High NEDD-9 and low FOXL-1 expression were found in intestinal type GC more than adjacent non-neoplastic mucosa (
p
< 0.001). NEDD-9 high expression and FOXL-1 low expression were associated with presence of helicobacter pylori gastritis (
p
= 0.010, 0.049), high grade (
p
= 0.007, 0.004), high stage (
p
< 0.001)
,
presence of distant metastases (
p
= 0.029, 0.021), poor DFS (
p
= 0.003), and OS rates (< 0.001).
Conclusion
NEDD-9 overexpression and FOXL-1 deficiency in intestinal type GC can help in prediction of tumor prognosis and it can guide the selection of patients for future therapies in gastric carcinoma.</description><subject>Cancer Research</subject><subject>Gastroenterology</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Radiotherapy</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kMtKAzEUhoMoXqov4EKydBPNbS5xJ22thaKCCu5CTDI1MpPUZAYsvrzRqktX58D5_p_DB8AxwWcE4-o8EYqpQJhihDGvCGJbYJ8ITlBZsnL7b6f1HjhI6RXjkheE7II9Rqt8wmIffNzFsPQh9U7De7f0rnFaeW0TDA28mU4mSEDlDby6fVogAqfvq2hTcsFD5-Hc9zYnvWrhw3pl4UylPuaisYra-dCpi5yF864bfHhxqQ_6xXa5v4X3_WDWh2CnUW2yRz9zBB6vpg_ja7S4nc3HlwukGa96xE2NNVFc8FoLzlhVFFQJVTembGxBqKJcc9XUvBYVrmpLsdXCMGMwL0piBBuB003vKoa3IX8sO5e0bVvlbRiSpJxxXmeYZ5RuUB1DStE2chVdp-JaEiy_pMuNdJmly2_pkuXQyU__8NxZ8xf5tZwBtgFSPvmljfI1DDFrS__VfgILsYxh</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Elaidy, Noha F.</creator><creator>Harb, Ola A.</creator><creator>Mohamed, Abdel Motaleb</creator><creator>Hemeda, Rehab</creator><creator>Taha, Heba F.</creator><creator>Samir, Amr</creator><creator>Elsayed, Ahmed M.</creator><creator>Osman, Gamal</creator><creator>Hendawy, Elsayed I El</creator><general>Springer US</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4396-3101</orcidid></search><sort><creationdate>20210601</creationdate><title>Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study</title><author>Elaidy, Noha F. ; Harb, Ola A. ; Mohamed, Abdel Motaleb ; Hemeda, Rehab ; Taha, Heba F. ; Samir, Amr ; Elsayed, Ahmed M. ; Osman, Gamal ; Hendawy, Elsayed I El</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-4d80c1a4948c94337552a9a8fd6fe512a24c4af84897078e20ec9d3dd04561d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cancer Research</topic><topic>Gastroenterology</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Radiotherapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elaidy, Noha F.</creatorcontrib><creatorcontrib>Harb, Ola A.</creatorcontrib><creatorcontrib>Mohamed, Abdel Motaleb</creatorcontrib><creatorcontrib>Hemeda, Rehab</creatorcontrib><creatorcontrib>Taha, Heba F.</creatorcontrib><creatorcontrib>Samir, Amr</creatorcontrib><creatorcontrib>Elsayed, Ahmed M.</creatorcontrib><creatorcontrib>Osman, Gamal</creatorcontrib><creatorcontrib>Hendawy, Elsayed I El</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elaidy, Noha F.</au><au>Harb, Ola A.</au><au>Mohamed, Abdel Motaleb</au><au>Hemeda, Rehab</au><au>Taha, Heba F.</au><au>Samir, Amr</au><au>Elsayed, Ahmed M.</au><au>Osman, Gamal</au><au>Hendawy, Elsayed I El</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>52</volume><issue>2</issue><spage>728</spage><epage>737</epage><pages>728-737</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Background
Gastric cancer (GC) is mostly diagnosed at advanced stage, so prognosis is poor. Therefore, it is necessary to understand the molecular mechanism of GC development to design new targeted treatment to improve the prognosis of gastric cancer patients.
Aim of the Work
To assess the prognostic value of NEDD-9 and FOXL-1 expression in intestinal type gastric cancer patients, as well as their relationship to clinicopathologic features of the disease and patients outcome.
Patients and Methods
This is a retrospective study; we included 50 sections from formalin-fixed, paraffin-embedded tissue samples which included intestinal type GC and adjacent non-neoplastic gastric mucosa in the same block that were subjected to immunohistochemistry with anti-NEDD-9 and anti-FOXL-1 antibody. Patients were retrospectively followed up for about 5 years for assessment of tumor progression and survival in relation to marker expression.
Results
High NEDD-9 and low FOXL-1 expression were found in intestinal type GC more than adjacent non-neoplastic mucosa (
p
< 0.001). NEDD-9 high expression and FOXL-1 low expression were associated with presence of helicobacter pylori gastritis (
p
= 0.010, 0.049), high grade (
p
= 0.007, 0.004), high stage (
p
< 0.001)
,
presence of distant metastases (
p
= 0.029, 0.021), poor DFS (
p
= 0.003), and OS rates (< 0.001).
Conclusion
NEDD-9 overexpression and FOXL-1 deficiency in intestinal type GC can help in prediction of tumor prognosis and it can guide the selection of patients for future therapies in gastric carcinoma.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32794109</pmid><doi>10.1007/s12029-020-00471-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4396-3101</orcidid></addata></record> |
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| subjects | Cancer Research Gastroenterology Internal Medicine Medicine Medicine & Public Health Oncology Original Research Radiotherapy |
| title | Prognostic Significances of NEDD-9 and FOXL-1 Expression in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study |
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