Anemia after kidney transplantation: Does its basis differ from anemia in chronic kidney disease?
Background Although similar factors play a role in both PTA and anemia in patients with CKD, additional risk factors exist in the pathogenesis of PTA. The present study aimed at comparing anemia and inflammation‐related parameters between RTx recipients and CKD patients and elucidating the risk fact...
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| Veröffentlicht in: | Pediatric transplantation 2020-12, Vol.24 (8), p.e13818-n/a |
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| container_title | Pediatric transplantation |
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| creator | Oruç, Çiğdem Canpolat, Nur Pehlivan, Esra Balcı Ekmekçi, Özlem Ağbaş, Ayşe Çalışkan, Salim Sever, Fatma Lale |
| description | Background
Although similar factors play a role in both PTA and anemia in patients with CKD, additional risk factors exist in the pathogenesis of PTA. The present study aimed at comparing anemia and inflammation‐related parameters between RTx recipients and CKD patients and elucidating the risk factors of PTA.
Methods
This single‐centered, cross‐sectional study consisted of 68 participants: 48 were in the RTx group and 20 were in the CKD group. The CKD patients were comparable to the RTx recipients in terms of age, gender, and eGFR. Serum levels of EPO, hepcidin, and IL‐6 were measured by enzyme‐linked immunosorbent assays. The ratio of EPO/Hb was calculated to estimate endogenous EPO resistance.
Results
The prevalence of anemia was 46% in the RTx group and 30% in the CKD group (P = .23). RTx recipients had significantly lower Hb (P = .04), higher EPO (P |
| doi_str_mv | 10.1111/petr.13818 |
| format | Article |
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Although similar factors play a role in both PTA and anemia in patients with CKD, additional risk factors exist in the pathogenesis of PTA. The present study aimed at comparing anemia and inflammation‐related parameters between RTx recipients and CKD patients and elucidating the risk factors of PTA.
Methods
This single‐centered, cross‐sectional study consisted of 68 participants: 48 were in the RTx group and 20 were in the CKD group. The CKD patients were comparable to the RTx recipients in terms of age, gender, and eGFR. Serum levels of EPO, hepcidin, and IL‐6 were measured by enzyme‐linked immunosorbent assays. The ratio of EPO/Hb was calculated to estimate endogenous EPO resistance.
Results
The prevalence of anemia was 46% in the RTx group and 30% in the CKD group (P = .23). RTx recipients had significantly lower Hb (P = .04), higher EPO (P < .001), and ferritin levels (P = .001), and higher EPO/Hb ratios (P < .001); however, CKD patients showed a higher frequency of absolute iron deficiency (P = .008). Neither hepcidin nor IL‐6 levels differed between the two groups. Hb level of RTx recipients was correlated with only eGFR (r = .437, P = .002) but not with any of the transplantation‐related factors, while Fe level was the only parameter to be correlated with Hb level of CKD patients (r = .622, P = .01).
Conclusion
In the present study comparing GFR‐matched RTx and CKD patients, lower GFR level appears to be the factor most strongly associated with anemia, and endogenous EPO resistance is among the contributing factors to PTA.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.13818</identifier><identifier>PMID: 32797673</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Anemia ; Epidermal growth factor receptors ; erythropoietin resistance ; Ferritin ; Hepcidin ; Iron deficiency ; Kidney diseases ; Kidney transplantation ; Kidney transplants ; Nutrient deficiency ; post‐transplant anemia ; Risk factors ; Serum levels</subject><ispartof>Pediatric transplantation, 2020-12, Vol.24 (8), p.e13818-n/a</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3578-2317753fc5f1ee7c7a83dbea297f043dade07ac0ccc163b48df8f76ad2ee946d3</citedby><cites>FETCH-LOGICAL-c3578-2317753fc5f1ee7c7a83dbea297f043dade07ac0ccc163b48df8f76ad2ee946d3</cites><orcidid>0000-0002-6315-2138 ; 0000-0002-3316-8032 ; 0000-0002-3420-9756 ; 0000-0002-3658-8622 ; 0000-0002-5918-6204 ; 0000-0001-7432-9915 ; 0000-0002-9659-0601</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpetr.13818$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpetr.13818$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32797673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oruç, Çiğdem</creatorcontrib><creatorcontrib>Canpolat, Nur</creatorcontrib><creatorcontrib>Pehlivan, Esra</creatorcontrib><creatorcontrib>Balcı Ekmekçi, Özlem</creatorcontrib><creatorcontrib>Ağbaş, Ayşe</creatorcontrib><creatorcontrib>Çalışkan, Salim</creatorcontrib><creatorcontrib>Sever, Fatma Lale</creatorcontrib><title>Anemia after kidney transplantation: Does its basis differ from anemia in chronic kidney disease?</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>Background
Although similar factors play a role in both PTA and anemia in patients with CKD, additional risk factors exist in the pathogenesis of PTA. The present study aimed at comparing anemia and inflammation‐related parameters between RTx recipients and CKD patients and elucidating the risk factors of PTA.
Methods
This single‐centered, cross‐sectional study consisted of 68 participants: 48 were in the RTx group and 20 were in the CKD group. The CKD patients were comparable to the RTx recipients in terms of age, gender, and eGFR. Serum levels of EPO, hepcidin, and IL‐6 were measured by enzyme‐linked immunosorbent assays. The ratio of EPO/Hb was calculated to estimate endogenous EPO resistance.
Results
The prevalence of anemia was 46% in the RTx group and 30% in the CKD group (P = .23). RTx recipients had significantly lower Hb (P = .04), higher EPO (P < .001), and ferritin levels (P = .001), and higher EPO/Hb ratios (P < .001); however, CKD patients showed a higher frequency of absolute iron deficiency (P = .008). Neither hepcidin nor IL‐6 levels differed between the two groups. Hb level of RTx recipients was correlated with only eGFR (r = .437, P = .002) but not with any of the transplantation‐related factors, while Fe level was the only parameter to be correlated with Hb level of CKD patients (r = .622, P = .01).
Conclusion
In the present study comparing GFR‐matched RTx and CKD patients, lower GFR level appears to be the factor most strongly associated with anemia, and endogenous EPO resistance is among the contributing factors to PTA.</description><subject>Anemia</subject><subject>Epidermal growth factor receptors</subject><subject>erythropoietin resistance</subject><subject>Ferritin</subject><subject>Hepcidin</subject><subject>Iron deficiency</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Kidney transplants</subject><subject>Nutrient deficiency</subject><subject>post‐transplant anemia</subject><subject>Risk factors</subject><subject>Serum levels</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp90MtKAzEUBuAgiq3VjQ8gATciTM1tJhk3It5BUKSuhzQ5wdTOTE2mSN_e2LEuXJjNyeLLz8mP0CElY5rO2QK6MKZcUbWFhpSXZcaJKLbXd5lxKtgA7cU4I4QWQoldNOBMlrKQfIj0ZQO111i7DgJ-97aBFe6CbuJirptOd75tzvF1CxH7LuKpjj5i651L2oW2xrp_7xts3kLbeLMJsT6CjnCxj3acnkc4-Jkj9Hp7M7m6zx6f7h6uLh8zw3OpMsaplDl3JncUQBqpFbdT0KyUjghutQUitSHGGFrwqVDWKScLbRlAKQrLR-ikz12E9mMJsatqHw3M0zegXcaKCS6EYpzwRI__0Fm7DE3aLqmCiVyxPE_qtFcmtDEGcNUi-FqHVUVJ9V189V18tS4-4aOfyOW0BvtLN00nQHvw6eew-ieqer6ZvPShX7jPjrc</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Oruç, Çiğdem</creator><creator>Canpolat, Nur</creator><creator>Pehlivan, Esra</creator><creator>Balcı Ekmekçi, Özlem</creator><creator>Ağbaş, Ayşe</creator><creator>Çalışkan, Salim</creator><creator>Sever, Fatma Lale</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6315-2138</orcidid><orcidid>https://orcid.org/0000-0002-3316-8032</orcidid><orcidid>https://orcid.org/0000-0002-3420-9756</orcidid><orcidid>https://orcid.org/0000-0002-3658-8622</orcidid><orcidid>https://orcid.org/0000-0002-5918-6204</orcidid><orcidid>https://orcid.org/0000-0001-7432-9915</orcidid><orcidid>https://orcid.org/0000-0002-9659-0601</orcidid></search><sort><creationdate>202012</creationdate><title>Anemia after kidney transplantation: Does its basis differ from anemia in chronic kidney disease?</title><author>Oruç, Çiğdem ; Canpolat, Nur ; Pehlivan, Esra ; Balcı Ekmekçi, Özlem ; Ağbaş, Ayşe ; Çalışkan, Salim ; Sever, Fatma Lale</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3578-2317753fc5f1ee7c7a83dbea297f043dade07ac0ccc163b48df8f76ad2ee946d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anemia</topic><topic>Epidermal growth factor receptors</topic><topic>erythropoietin resistance</topic><topic>Ferritin</topic><topic>Hepcidin</topic><topic>Iron deficiency</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Kidney transplants</topic><topic>Nutrient deficiency</topic><topic>post‐transplant anemia</topic><topic>Risk factors</topic><topic>Serum levels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oruç, Çiğdem</creatorcontrib><creatorcontrib>Canpolat, Nur</creatorcontrib><creatorcontrib>Pehlivan, Esra</creatorcontrib><creatorcontrib>Balcı Ekmekçi, Özlem</creatorcontrib><creatorcontrib>Ağbaş, Ayşe</creatorcontrib><creatorcontrib>Çalışkan, Salim</creatorcontrib><creatorcontrib>Sever, Fatma Lale</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oruç, Çiğdem</au><au>Canpolat, Nur</au><au>Pehlivan, Esra</au><au>Balcı Ekmekçi, Özlem</au><au>Ağbaş, Ayşe</au><au>Çalışkan, Salim</au><au>Sever, Fatma Lale</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anemia after kidney transplantation: Does its basis differ from anemia in chronic kidney disease?</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2020-12</date><risdate>2020</risdate><volume>24</volume><issue>8</issue><spage>e13818</spage><epage>n/a</epage><pages>e13818-n/a</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Background
Although similar factors play a role in both PTA and anemia in patients with CKD, additional risk factors exist in the pathogenesis of PTA. The present study aimed at comparing anemia and inflammation‐related parameters between RTx recipients and CKD patients and elucidating the risk factors of PTA.
Methods
This single‐centered, cross‐sectional study consisted of 68 participants: 48 were in the RTx group and 20 were in the CKD group. The CKD patients were comparable to the RTx recipients in terms of age, gender, and eGFR. Serum levels of EPO, hepcidin, and IL‐6 were measured by enzyme‐linked immunosorbent assays. The ratio of EPO/Hb was calculated to estimate endogenous EPO resistance.
Results
The prevalence of anemia was 46% in the RTx group and 30% in the CKD group (P = .23). RTx recipients had significantly lower Hb (P = .04), higher EPO (P < .001), and ferritin levels (P = .001), and higher EPO/Hb ratios (P < .001); however, CKD patients showed a higher frequency of absolute iron deficiency (P = .008). Neither hepcidin nor IL‐6 levels differed between the two groups. Hb level of RTx recipients was correlated with only eGFR (r = .437, P = .002) but not with any of the transplantation‐related factors, while Fe level was the only parameter to be correlated with Hb level of CKD patients (r = .622, P = .01).
Conclusion
In the present study comparing GFR‐matched RTx and CKD patients, lower GFR level appears to be the factor most strongly associated with anemia, and endogenous EPO resistance is among the contributing factors to PTA.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32797673</pmid><doi>10.1111/petr.13818</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6315-2138</orcidid><orcidid>https://orcid.org/0000-0002-3316-8032</orcidid><orcidid>https://orcid.org/0000-0002-3420-9756</orcidid><orcidid>https://orcid.org/0000-0002-3658-8622</orcidid><orcidid>https://orcid.org/0000-0002-5918-6204</orcidid><orcidid>https://orcid.org/0000-0001-7432-9915</orcidid><orcidid>https://orcid.org/0000-0002-9659-0601</orcidid></addata></record> |
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| subjects | Anemia Epidermal growth factor receptors erythropoietin resistance Ferritin Hepcidin Iron deficiency Kidney diseases Kidney transplantation Kidney transplants Nutrient deficiency post‐transplant anemia Risk factors Serum levels |
| title | Anemia after kidney transplantation: Does its basis differ from anemia in chronic kidney disease? |
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