Risk of severe herpes zoster infection in patients with polycystic kidney disease: A nation‐wide cohort study with propensity score matching analysis
Background Polycystic kidney disease (PKD) is suggested to be likely associated with underlying immunological dysregulation. This lymphopenia poses a risk of viral infection. Data to elucidate the herpes virus infection risk in patients with PKD are lacking; therefore, we conducted a national‐wide p...
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| Veröffentlicht in: | International journal of clinical practice (Esher) 2021-04, Vol.75 (4), p.e13675-n/a |
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| container_title | International journal of clinical practice (Esher) |
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| creator | Yu, Tung‐Min Li, Chi‐Yuan Chuang, Ya‐Wen Chen, Cheng‐Hsu Lee, Brian K. Chung, Mu‐Chi Chiu, Hsien‐Fu Lin, Mei‐Chen Wu, Ming‐Ju Kao, Chia‐Hung |
| description | Background
Polycystic kidney disease (PKD) is suggested to be likely associated with underlying immunological dysregulation. This lymphopenia poses a risk of viral infection. Data to elucidate the herpes virus infection risk in patients with PKD are lacking; therefore, we conducted a national‐wide population‐based cohort study to investigate the herpes virus risk in PKD patients.
Methods
From the Taiwan National Health Insurance Research Database (NHIRD), patients who were hospitalised with a diagnosis of polycystic kidney disease were defined as case group of PKD patients; patients without any diagnosis of PKD during the study period were grouped into the non‐PKD cohort. The index date was set as the date when the patients were newly diagnosed with PKD. All study patients were followed up until the occurrence of herpes zoster infection, death, withdrawal from the NHIRD for other reasons, or until December 31, 2013.
Results
We included 4366 PKD patients and 4366 non‐PKD patients. The incidence rate and the risk of developing herpes zoster infection were estimated using multivariate stratified analyses. PKD patients had a 1.97‐fold risk of herpes zoster virus infection (aHR = 1.97, 95% CI 1.17‐3.31) compared with the non‐PKD cohort. On multilayer stratification, PKD patients without any comorbidities had a significantly increased risk of herpes zoster infection (aHR = 3.10, 95% CI 1.37‐7.00).
Conclusion
This is the first study to reveal a high risk of severe herpes zoster infection in patients with PKD. High index suspicion of severe herpes zoster infection should be maintained in clinical professionals. |
| doi_str_mv | 10.1111/ijcp.13675 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2434478183</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2434478183</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3575-712991071ba055c1cf443211ad4cb82e1a3aa83103a1270041a3a703e29cfbdc3</originalsourceid><addsrcrecordid>eNp9kU2O1DAQhS0EYn5gwwGQJTZopAwuO2kn7EYtfgaNBEKwjtxOhXZP2g4uh1ZYcQR23I-T4KYbFiyoTZVKX71X0mPsEYhLyPXMbex4CWqhqzvsFHQpC5Al3M2zWtRFJRScsDOijRCyqmpxn50oqZtaLupT9uO9o1seek74BSPyNcYRiX8NlDBy53u0yQWfJz6a5NAn4juX1nwMw2xnSs7yW9d5nHnnCA3hc37Fvdkf_fz2fec65DasQ0yc0tTNx-MYRvTk0szJhmy7Ncmunf_EjTfDTI4esHu9GQgfHvs5-_jyxYfl6-Lm7avr5dVNYVWlq0KDbBoQGlZGVJUF25elkgCmK-2qlghGGVMrEMqA1EKU-4UWCmVj-1Vn1Tl7etDNL32ekFK7dWRxGIzHMFErS1WWuoZaZfTJP-gmTDH_m6lKNDL7SpmpiwNlYyCK2LdjdFsT5xZEu4-r3cfV_o4rw4-PktNqi91f9E8-GYADsHMDzv-Raq_fLN8dRH8BnHejJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2509232122</pqid></control><display><type>article</type><title>Risk of severe herpes zoster infection in patients with polycystic kidney disease: A nation‐wide cohort study with propensity score matching analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Yu, Tung‐Min ; Li, Chi‐Yuan ; Chuang, Ya‐Wen ; Chen, Cheng‐Hsu ; Lee, Brian K. ; Chung, Mu‐Chi ; Chiu, Hsien‐Fu ; Lin, Mei‐Chen ; Wu, Ming‐Ju ; Kao, Chia‐Hung</creator><creatorcontrib>Yu, Tung‐Min ; Li, Chi‐Yuan ; Chuang, Ya‐Wen ; Chen, Cheng‐Hsu ; Lee, Brian K. ; Chung, Mu‐Chi ; Chiu, Hsien‐Fu ; Lin, Mei‐Chen ; Wu, Ming‐Ju ; Kao, Chia‐Hung</creatorcontrib><description>Background
Polycystic kidney disease (PKD) is suggested to be likely associated with underlying immunological dysregulation. This lymphopenia poses a risk of viral infection. Data to elucidate the herpes virus infection risk in patients with PKD are lacking; therefore, we conducted a national‐wide population‐based cohort study to investigate the herpes virus risk in PKD patients.
Methods
From the Taiwan National Health Insurance Research Database (NHIRD), patients who were hospitalised with a diagnosis of polycystic kidney disease were defined as case group of PKD patients; patients without any diagnosis of PKD during the study period were grouped into the non‐PKD cohort. The index date was set as the date when the patients were newly diagnosed with PKD. All study patients were followed up until the occurrence of herpes zoster infection, death, withdrawal from the NHIRD for other reasons, or until December 31, 2013.
Results
We included 4366 PKD patients and 4366 non‐PKD patients. The incidence rate and the risk of developing herpes zoster infection were estimated using multivariate stratified analyses. PKD patients had a 1.97‐fold risk of herpes zoster virus infection (aHR = 1.97, 95% CI 1.17‐3.31) compared with the non‐PKD cohort. On multilayer stratification, PKD patients without any comorbidities had a significantly increased risk of herpes zoster infection (aHR = 3.10, 95% CI 1.37‐7.00).
Conclusion
This is the first study to reveal a high risk of severe herpes zoster infection in patients with PKD. High index suspicion of severe herpes zoster infection should be maintained in clinical professionals.</description><identifier>ISSN: 1368-5031</identifier><identifier>EISSN: 1742-1241</identifier><identifier>DOI: 10.1111/ijcp.13675</identifier><identifier>PMID: 32798268</identifier><language>eng</language><publisher>England: Hindawi Limited</publisher><subject>Cohort analysis ; Cohort Studies ; cohort study ; Diagnosis ; herpes varicella‐zoster virus ; Herpes viruses ; Herpes zoster ; Herpes Zoster - complications ; Herpes Zoster - epidemiology ; Humans ; Incidence ; Infections ; Kidney diseases ; lymphocyte cell ; Lymphopenia ; Polycystic kidney ; polycystic kidney disease ; Polycystic Kidney Diseases - complications ; Polycystic Kidney Diseases - epidemiology ; Population studies ; Propensity Score ; Sodium ; Taiwan - epidemiology ; Viral infections ; Viruses</subject><ispartof>International journal of clinical practice (Esher), 2021-04, Vol.75 (4), p.e13675-n/a</ispartof><rights>2020 John Wiley & Sons Ltd</rights><rights>2020 John Wiley & Sons Ltd.</rights><rights>Copyright © 2021 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3575-712991071ba055c1cf443211ad4cb82e1a3aa83103a1270041a3a703e29cfbdc3</citedby><cites>FETCH-LOGICAL-c3575-712991071ba055c1cf443211ad4cb82e1a3aa83103a1270041a3a703e29cfbdc3</cites><orcidid>0000-0002-6368-3676</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fijcp.13675$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fijcp.13675$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32798268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Tung‐Min</creatorcontrib><creatorcontrib>Li, Chi‐Yuan</creatorcontrib><creatorcontrib>Chuang, Ya‐Wen</creatorcontrib><creatorcontrib>Chen, Cheng‐Hsu</creatorcontrib><creatorcontrib>Lee, Brian K.</creatorcontrib><creatorcontrib>Chung, Mu‐Chi</creatorcontrib><creatorcontrib>Chiu, Hsien‐Fu</creatorcontrib><creatorcontrib>Lin, Mei‐Chen</creatorcontrib><creatorcontrib>Wu, Ming‐Ju</creatorcontrib><creatorcontrib>Kao, Chia‐Hung</creatorcontrib><title>Risk of severe herpes zoster infection in patients with polycystic kidney disease: A nation‐wide cohort study with propensity score matching analysis</title><title>International journal of clinical practice (Esher)</title><addtitle>Int J Clin Pract</addtitle><description>Background
Polycystic kidney disease (PKD) is suggested to be likely associated with underlying immunological dysregulation. This lymphopenia poses a risk of viral infection. Data to elucidate the herpes virus infection risk in patients with PKD are lacking; therefore, we conducted a national‐wide population‐based cohort study to investigate the herpes virus risk in PKD patients.
Methods
From the Taiwan National Health Insurance Research Database (NHIRD), patients who were hospitalised with a diagnosis of polycystic kidney disease were defined as case group of PKD patients; patients without any diagnosis of PKD during the study period were grouped into the non‐PKD cohort. The index date was set as the date when the patients were newly diagnosed with PKD. All study patients were followed up until the occurrence of herpes zoster infection, death, withdrawal from the NHIRD for other reasons, or until December 31, 2013.
Results
We included 4366 PKD patients and 4366 non‐PKD patients. The incidence rate and the risk of developing herpes zoster infection were estimated using multivariate stratified analyses. PKD patients had a 1.97‐fold risk of herpes zoster virus infection (aHR = 1.97, 95% CI 1.17‐3.31) compared with the non‐PKD cohort. On multilayer stratification, PKD patients without any comorbidities had a significantly increased risk of herpes zoster infection (aHR = 3.10, 95% CI 1.37‐7.00).
Conclusion
This is the first study to reveal a high risk of severe herpes zoster infection in patients with PKD. High index suspicion of severe herpes zoster infection should be maintained in clinical professionals.</description><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>cohort study</subject><subject>Diagnosis</subject><subject>herpes varicella‐zoster virus</subject><subject>Herpes viruses</subject><subject>Herpes zoster</subject><subject>Herpes Zoster - complications</subject><subject>Herpes Zoster - epidemiology</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infections</subject><subject>Kidney diseases</subject><subject>lymphocyte cell</subject><subject>Lymphopenia</subject><subject>Polycystic kidney</subject><subject>polycystic kidney disease</subject><subject>Polycystic Kidney Diseases - complications</subject><subject>Polycystic Kidney Diseases - epidemiology</subject><subject>Population studies</subject><subject>Propensity Score</subject><subject>Sodium</subject><subject>Taiwan - epidemiology</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>1368-5031</issn><issn>1742-1241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2O1DAQhS0EYn5gwwGQJTZopAwuO2kn7EYtfgaNBEKwjtxOhXZP2g4uh1ZYcQR23I-T4KYbFiyoTZVKX71X0mPsEYhLyPXMbex4CWqhqzvsFHQpC5Al3M2zWtRFJRScsDOijRCyqmpxn50oqZtaLupT9uO9o1seek74BSPyNcYRiX8NlDBy53u0yQWfJz6a5NAn4juX1nwMw2xnSs7yW9d5nHnnCA3hc37Fvdkf_fz2fec65DasQ0yc0tTNx-MYRvTk0szJhmy7Ncmunf_EjTfDTI4esHu9GQgfHvs5-_jyxYfl6-Lm7avr5dVNYVWlq0KDbBoQGlZGVJUF25elkgCmK-2qlghGGVMrEMqA1EKU-4UWCmVj-1Vn1Tl7etDNL32ekFK7dWRxGIzHMFErS1WWuoZaZfTJP-gmTDH_m6lKNDL7SpmpiwNlYyCK2LdjdFsT5xZEu4-r3cfV_o4rw4-PktNqi91f9E8-GYADsHMDzv-Raq_fLN8dRH8BnHejJg</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Yu, Tung‐Min</creator><creator>Li, Chi‐Yuan</creator><creator>Chuang, Ya‐Wen</creator><creator>Chen, Cheng‐Hsu</creator><creator>Lee, Brian K.</creator><creator>Chung, Mu‐Chi</creator><creator>Chiu, Hsien‐Fu</creator><creator>Lin, Mei‐Chen</creator><creator>Wu, Ming‐Ju</creator><creator>Kao, Chia‐Hung</creator><general>Hindawi Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6368-3676</orcidid></search><sort><creationdate>202104</creationdate><title>Risk of severe herpes zoster infection in patients with polycystic kidney disease: A nation‐wide cohort study with propensity score matching analysis</title><author>Yu, Tung‐Min ; Li, Chi‐Yuan ; Chuang, Ya‐Wen ; Chen, Cheng‐Hsu ; Lee, Brian K. ; Chung, Mu‐Chi ; Chiu, Hsien‐Fu ; Lin, Mei‐Chen ; Wu, Ming‐Ju ; Kao, Chia‐Hung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3575-712991071ba055c1cf443211ad4cb82e1a3aa83103a1270041a3a703e29cfbdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>cohort study</topic><topic>Diagnosis</topic><topic>herpes varicella‐zoster virus</topic><topic>Herpes viruses</topic><topic>Herpes zoster</topic><topic>Herpes Zoster - complications</topic><topic>Herpes Zoster - epidemiology</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infections</topic><topic>Kidney diseases</topic><topic>lymphocyte cell</topic><topic>Lymphopenia</topic><topic>Polycystic kidney</topic><topic>polycystic kidney disease</topic><topic>Polycystic Kidney Diseases - complications</topic><topic>Polycystic Kidney Diseases - epidemiology</topic><topic>Population studies</topic><topic>Propensity Score</topic><topic>Sodium</topic><topic>Taiwan - epidemiology</topic><topic>Viral infections</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Tung‐Min</creatorcontrib><creatorcontrib>Li, Chi‐Yuan</creatorcontrib><creatorcontrib>Chuang, Ya‐Wen</creatorcontrib><creatorcontrib>Chen, Cheng‐Hsu</creatorcontrib><creatorcontrib>Lee, Brian K.</creatorcontrib><creatorcontrib>Chung, Mu‐Chi</creatorcontrib><creatorcontrib>Chiu, Hsien‐Fu</creatorcontrib><creatorcontrib>Lin, Mei‐Chen</creatorcontrib><creatorcontrib>Wu, Ming‐Ju</creatorcontrib><creatorcontrib>Kao, Chia‐Hung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of clinical practice (Esher)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Tung‐Min</au><au>Li, Chi‐Yuan</au><au>Chuang, Ya‐Wen</au><au>Chen, Cheng‐Hsu</au><au>Lee, Brian K.</au><au>Chung, Mu‐Chi</au><au>Chiu, Hsien‐Fu</au><au>Lin, Mei‐Chen</au><au>Wu, Ming‐Ju</au><au>Kao, Chia‐Hung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of severe herpes zoster infection in patients with polycystic kidney disease: A nation‐wide cohort study with propensity score matching analysis</atitle><jtitle>International journal of clinical practice (Esher)</jtitle><addtitle>Int J Clin Pract</addtitle><date>2021-04</date><risdate>2021</risdate><volume>75</volume><issue>4</issue><spage>e13675</spage><epage>n/a</epage><pages>e13675-n/a</pages><issn>1368-5031</issn><eissn>1742-1241</eissn><abstract>Background
Polycystic kidney disease (PKD) is suggested to be likely associated with underlying immunological dysregulation. This lymphopenia poses a risk of viral infection. Data to elucidate the herpes virus infection risk in patients with PKD are lacking; therefore, we conducted a national‐wide population‐based cohort study to investigate the herpes virus risk in PKD patients.
Methods
From the Taiwan National Health Insurance Research Database (NHIRD), patients who were hospitalised with a diagnosis of polycystic kidney disease were defined as case group of PKD patients; patients without any diagnosis of PKD during the study period were grouped into the non‐PKD cohort. The index date was set as the date when the patients were newly diagnosed with PKD. All study patients were followed up until the occurrence of herpes zoster infection, death, withdrawal from the NHIRD for other reasons, or until December 31, 2013.
Results
We included 4366 PKD patients and 4366 non‐PKD patients. The incidence rate and the risk of developing herpes zoster infection were estimated using multivariate stratified analyses. PKD patients had a 1.97‐fold risk of herpes zoster virus infection (aHR = 1.97, 95% CI 1.17‐3.31) compared with the non‐PKD cohort. On multilayer stratification, PKD patients without any comorbidities had a significantly increased risk of herpes zoster infection (aHR = 3.10, 95% CI 1.37‐7.00).
Conclusion
This is the first study to reveal a high risk of severe herpes zoster infection in patients with PKD. High index suspicion of severe herpes zoster infection should be maintained in clinical professionals.</abstract><cop>England</cop><pub>Hindawi Limited</pub><pmid>32798268</pmid><doi>10.1111/ijcp.13675</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-6368-3676</orcidid></addata></record> |
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| subjects | Cohort analysis Cohort Studies cohort study Diagnosis herpes varicella‐zoster virus Herpes viruses Herpes zoster Herpes Zoster - complications Herpes Zoster - epidemiology Humans Incidence Infections Kidney diseases lymphocyte cell Lymphopenia Polycystic kidney polycystic kidney disease Polycystic Kidney Diseases - complications Polycystic Kidney Diseases - epidemiology Population studies Propensity Score Sodium Taiwan - epidemiology Viral infections Viruses |
| title | Risk of severe herpes zoster infection in patients with polycystic kidney disease: A nation‐wide cohort study with propensity score matching analysis |
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