Single-Cell Analysis of Signaling Proteins Provides Insights into Proapoptotic Properties of Anticancer Drugs

Single-cell DNA analysis technology has provided unprecedented insights into many physiological and pathological processes. In contrast, technologies that allow protein analysis in single cells have lagged behind. Herein, a method called single-cell Plasmonic ImmunoSandwich Assay (scPISA) that is ca...

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Veröffentlicht in:	Analytical chemistry (Washington) 2020-09, Vol.92 (18), p.12498-12508
Hauptverfasser:	Wen, Yanrong, Liu, Jia, He, Hui, Li, Shawn S.C, Liu, Zhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycin Analytical chemistry Anticancer properties Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antineoplastic drugs Antitumor agents Apoptosis Apoptosis - drug effects Cancer Caspase 3 - analysis Caspase 3 - metabolism Caspase-3 Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Cytochrome Cytochrome c Cytochromes Cytochromes c - analysis Cytochromes c - metabolism Cytotoxicity Dactinomycin - chemistry Dactinomycin - pharmacology Deoxyribonucleic acid DNA Drug Screening Assays, Antitumor Drugs Humans Immunoassay Kinetics Metformin Metformin - chemistry Metformin - pharmacology Particle Size Plasmonics Precision medicine Proteins Signaling Single-Cell Analysis Surface Properties Survivin Technology assessment
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