Relationships between increased circulating YKL-40, IL-6 and TNF-α levels and phenotypes and disease activity of primary Sjögren's syndrome

•Serum levels of YKL-40, IL-6 and TNF-α were increased in pSS patients.•YKL-40, IL-6 and TNF-α were mainly involved in systemic inflammation of pSS.•Each of YKL-40, IL-6 and TNF-α had separate association with distinct pSS phenotype. There is now no single score or marker useful for evaluating disea...

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