Thermoprotective molecules to improve oocyte competence under elevated temperature

Heat stress is an environmental factor that challenges livestock by disturbing animal homeostasis. Despite the broad detrimental effects of heat stress on reproductive function, the germline and the early preimplantation embryo are particularly prone. There is extensive evidence that elevated temperature reduces oocyte developmental competence through a series of cellular and molecular damages. Further research revealed that the oocyte respond to stress by activating cellular mechanisms such as heat shock response, unfolded protein response and autophagy to improve survival under heat shock. Such knowledge paved the way for the identification of thermoprotective molecules that alleviate heat-induced oocyte oxidative stress, organelle damage, and apoptosis. Therefore, this review depicts the deleterious effects of heat shock on oocyte developmental competence, heat-induced cellular and molecular changes, outlines pro-survival cellular mechanisms and explores thermoprotective molecules to improve oocyte competence. [Display omitted] •Heat stress diminishes oocyte developmental competence.•Cellular adaptative mechanisms contribute to oocyte survival under heat stress.•Understanding heat stress effects on oocytes led to thermoprotective approaches.•Thermoprotective molecules ensure oocyte competence under heat stress.