Hemodynamic changes in neonates born to mothers with Graves’ disease
Purpose Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD. Methods Overall, 80 newbor...
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| Veröffentlicht in: | Endocrine 2021-04, Vol.72 (1), p.171-178 |
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| creator | Ishikawa, Takamichi Uchiyama, Hiroki Iwashima, Satoru Baba, Toru Ohishi, Akira Iijima, Shigeo Itoh, Hiroaki |
| description | Purpose
Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD.
Methods
Overall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT
3
), free thyroxine (FT
4
), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of life).
Results
The TRAb-positive newborns had higher FT
4
levels and CI on Day 5 (both
p
|
| doi_str_mv | 10.1007/s12020-020-02443-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2434059659</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2434059659</sourcerecordid><originalsourceid>FETCH-LOGICAL-c370t-1b30e0455c9410df8758898f2677a3e678f6ac79ab33d29665d986c6058a15a03</originalsourceid><addsrcrecordid>eNp9kM9KAzEQxoMotv55AQ8S8OJldTbZ7CZHKbYVCl4UvIXsbtZu6W5qsrX05mv4ej6JI1sVPAgZMjDffPPxI-QshqsYILsOMQMGUV9JwqPNHhnGQqgIcL6PPRciApBPA3IUwgKAMZZmh2TAWSaFVHJIxlPbuHLbmqYuaDE37bMNtG5pa11rOuxz51vaOdq4bm59oJu6m9OJN682fLy907IO1gR7Qg4qswz2dPcfk8fx7cNoGs3uJ3ejm1lU8Ay6KM45WEiEKFQSQ1nJTEiMUWGqzHCbZrJKTZEpk3NeMpWmolQyLVIQ0sTCAD8ml73vyruXtQ2dbupQ2OXSYOB10CzhCQiVCoXSiz_ShVv7FtNpJhAcPs5QxXpV4V0I3lZ65evG-K2OQX9R1j1l3RdS1htcOt9Zr_PGlj8r31hRwHtBwBEi9b-3_7H9BFmyhv4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2520220232</pqid></control><display><type>article</type><title>Hemodynamic changes in neonates born to mothers with Graves’ disease</title><source>SpringerLink Journals</source><creator>Ishikawa, Takamichi ; Uchiyama, Hiroki ; Iwashima, Satoru ; Baba, Toru ; Ohishi, Akira ; Iijima, Shigeo ; Itoh, Hiroaki</creator><creatorcontrib>Ishikawa, Takamichi ; Uchiyama, Hiroki ; Iwashima, Satoru ; Baba, Toru ; Ohishi, Akira ; Iijima, Shigeo ; Itoh, Hiroaki</creatorcontrib><description>Purpose
Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD.
Methods
Overall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT
3
), free thyroxine (FT
4
), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of life).
Results
The TRAb-positive newborns had higher FT
4
levels and CI on Day 5 (both
p
< 0.05) and higher FT
3
(
p
< 0.05) and FT
4
levels (
p
< 0.01) and CI (
p
< 0.01) but lower TSH levels (
p
< 0.05) on Day 10 than the TRAb-negative newborns. The TRAb-positive newborns had significantly higher NT-proBNP levels on Days 5 (median 752 vs. 563 pg/mL,
p
= 0.034) and 10 (median 789 vs. 552 pg/mL,
p
= 0.002) than the TRAb-negative newborns.
Conclusions
Hemodynamic changes in neonates born to TRAb-positive mothers with GD resulted in a higher CI and NT-proBNP levels than in those with TRAb-negative mothers from postnatal days 5 to 10.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-020-02443-w</identifier><identifier>PMID: 32785898</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Brain natriuretic peptide ; Coronary artery disease ; Diabetes ; Echocardiography ; Endocrinology ; Graves' disease ; Heart diseases ; Hemodynamics ; Humanities and Social Sciences ; Hyperthyroidism ; Internal Medicine ; Medicine ; Medicine & Public Health ; Morbidity ; Mothers ; multidisciplinary ; Neonates ; Original Article ; Science ; Serum levels ; Thyroid hormones ; Thyroid-stimulating hormone ; Thyroxine ; Triiodothyronine</subject><ispartof>Endocrine, 2021-04, Vol.72 (1), p.171-178</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c370t-1b30e0455c9410df8758898f2677a3e678f6ac79ab33d29665d986c6058a15a03</cites><orcidid>0000-0002-7118-3014</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-020-02443-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-020-02443-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32785898$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ishikawa, Takamichi</creatorcontrib><creatorcontrib>Uchiyama, Hiroki</creatorcontrib><creatorcontrib>Iwashima, Satoru</creatorcontrib><creatorcontrib>Baba, Toru</creatorcontrib><creatorcontrib>Ohishi, Akira</creatorcontrib><creatorcontrib>Iijima, Shigeo</creatorcontrib><creatorcontrib>Itoh, Hiroaki</creatorcontrib><title>Hemodynamic changes in neonates born to mothers with Graves’ disease</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>Purpose
Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD.
Methods
Overall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT
3
), free thyroxine (FT
4
), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of life).
Results
The TRAb-positive newborns had higher FT
4
levels and CI on Day 5 (both
p
< 0.05) and higher FT
3
(
p
< 0.05) and FT
4
levels (
p
< 0.01) and CI (
p
< 0.01) but lower TSH levels (
p
< 0.05) on Day 10 than the TRAb-negative newborns. The TRAb-positive newborns had significantly higher NT-proBNP levels on Days 5 (median 752 vs. 563 pg/mL,
p
= 0.034) and 10 (median 789 vs. 552 pg/mL,
p
= 0.002) than the TRAb-negative newborns.
Conclusions
Hemodynamic changes in neonates born to TRAb-positive mothers with GD resulted in a higher CI and NT-proBNP levels than in those with TRAb-negative mothers from postnatal days 5 to 10.</description><subject>Brain natriuretic peptide</subject><subject>Coronary artery disease</subject><subject>Diabetes</subject><subject>Echocardiography</subject><subject>Endocrinology</subject><subject>Graves' disease</subject><subject>Heart diseases</subject><subject>Hemodynamics</subject><subject>Humanities and Social Sciences</subject><subject>Hyperthyroidism</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Mothers</subject><subject>multidisciplinary</subject><subject>Neonates</subject><subject>Original Article</subject><subject>Science</subject><subject>Serum levels</subject><subject>Thyroid hormones</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>Triiodothyronine</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kM9KAzEQxoMotv55AQ8S8OJldTbZ7CZHKbYVCl4UvIXsbtZu6W5qsrX05mv4ej6JI1sVPAgZMjDffPPxI-QshqsYILsOMQMGUV9JwqPNHhnGQqgIcL6PPRciApBPA3IUwgKAMZZmh2TAWSaFVHJIxlPbuHLbmqYuaDE37bMNtG5pa11rOuxz51vaOdq4bm59oJu6m9OJN682fLy907IO1gR7Qg4qswz2dPcfk8fx7cNoGs3uJ3ejm1lU8Ay6KM45WEiEKFQSQ1nJTEiMUWGqzHCbZrJKTZEpk3NeMpWmolQyLVIQ0sTCAD8ml73vyruXtQ2dbupQ2OXSYOB10CzhCQiVCoXSiz_ShVv7FtNpJhAcPs5QxXpV4V0I3lZ65evG-K2OQX9R1j1l3RdS1htcOt9Zr_PGlj8r31hRwHtBwBEi9b-3_7H9BFmyhv4</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Ishikawa, Takamichi</creator><creator>Uchiyama, Hiroki</creator><creator>Iwashima, Satoru</creator><creator>Baba, Toru</creator><creator>Ohishi, Akira</creator><creator>Iijima, Shigeo</creator><creator>Itoh, Hiroaki</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7118-3014</orcidid></search><sort><creationdate>20210401</creationdate><title>Hemodynamic changes in neonates born to mothers with Graves’ disease</title><author>Ishikawa, Takamichi ; Uchiyama, Hiroki ; Iwashima, Satoru ; Baba, Toru ; Ohishi, Akira ; Iijima, Shigeo ; Itoh, Hiroaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c370t-1b30e0455c9410df8758898f2677a3e678f6ac79ab33d29665d986c6058a15a03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brain natriuretic peptide</topic><topic>Coronary artery disease</topic><topic>Diabetes</topic><topic>Echocardiography</topic><topic>Endocrinology</topic><topic>Graves' disease</topic><topic>Heart diseases</topic><topic>Hemodynamics</topic><topic>Humanities and Social Sciences</topic><topic>Hyperthyroidism</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Mothers</topic><topic>multidisciplinary</topic><topic>Neonates</topic><topic>Original Article</topic><topic>Science</topic><topic>Serum levels</topic><topic>Thyroid hormones</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><topic>Triiodothyronine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishikawa, Takamichi</creatorcontrib><creatorcontrib>Uchiyama, Hiroki</creatorcontrib><creatorcontrib>Iwashima, Satoru</creatorcontrib><creatorcontrib>Baba, Toru</creatorcontrib><creatorcontrib>Ohishi, Akira</creatorcontrib><creatorcontrib>Iijima, Shigeo</creatorcontrib><creatorcontrib>Itoh, Hiroaki</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishikawa, Takamichi</au><au>Uchiyama, Hiroki</au><au>Iwashima, Satoru</au><au>Baba, Toru</au><au>Ohishi, Akira</au><au>Iijima, Shigeo</au><au>Itoh, Hiroaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hemodynamic changes in neonates born to mothers with Graves’ disease</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>72</volume><issue>1</issue><spage>171</spage><epage>178</epage><pages>171-178</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>Purpose
Cardiac insufficiency is a major morbidity in neonatal hyperthyroidism. It is important to assess the hemodynamics in neonates born to mothers with Graves’ disease (GD). This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD.
Methods
Overall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT
3
), free thyroxine (FT
4
), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of life).
Results
The TRAb-positive newborns had higher FT
4
levels and CI on Day 5 (both
p
< 0.05) and higher FT
3
(
p
< 0.05) and FT
4
levels (
p
< 0.01) and CI (
p
< 0.01) but lower TSH levels (
p
< 0.05) on Day 10 than the TRAb-negative newborns. The TRAb-positive newborns had significantly higher NT-proBNP levels on Days 5 (median 752 vs. 563 pg/mL,
p
= 0.034) and 10 (median 789 vs. 552 pg/mL,
p
= 0.002) than the TRAb-negative newborns.
Conclusions
Hemodynamic changes in neonates born to TRAb-positive mothers with GD resulted in a higher CI and NT-proBNP levels than in those with TRAb-negative mothers from postnatal days 5 to 10.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32785898</pmid><doi>10.1007/s12020-020-02443-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-7118-3014</orcidid><oa>free_for_read</oa></addata></record> |
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| source | SpringerLink Journals |
| subjects | Brain natriuretic peptide Coronary artery disease Diabetes Echocardiography Endocrinology Graves' disease Heart diseases Hemodynamics Humanities and Social Sciences Hyperthyroidism Internal Medicine Medicine Medicine & Public Health Morbidity Mothers multidisciplinary Neonates Original Article Science Serum levels Thyroid hormones Thyroid-stimulating hormone Thyroxine Triiodothyronine |
| title | Hemodynamic changes in neonates born to mothers with Graves’ disease |
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