Cancer metastasis‐associated protein 1 localizes to the nucleolus and regulates pre‐rRNA synthesis in cancer cells

Metastasis‐associated protein 1 (MTA1) is a critical component of the nucleosome remodeling and histone deacetylase (NuRD) complex. MTA1 has several biological functions, and it is closely associated with the malignant properties of human cancers; however, the mechanisms and subcellular localization...

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Veröffentlicht in:	Journal of cellular biochemistry 2021-02, Vol.122 (2), p.180-188
Hauptverfasser:	Liu, Jian, Li, Chunxiao, Xue, Hongsheng, Li, Lina, Liu, Qun, Wang, Haijuan, Wen, Tao, Qian, Haili
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Cell Nucleolus - metabolism Chemical synthesis Critical components Fibrillarin Histone deacetylase Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Immunoelectron microscopy Immunofluorescence Immunoprecipitation Localization Metastases Metastasis Microscopy, Immunoelectron MTA1 Nucleoli Nucleolin nucleolus Polymerase chain reaction pre‐rRNA transcription Promoter Regions, Genetic - genetics Proteins Repressor Proteins - genetics Repressor Proteins - metabolism RNA Precursors - metabolism rRNA subcellular localization Trans-Activators - genetics Trans-Activators - metabolism Transcription activation Transcription, Genetic - genetics
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