Effects of Fluoride on Oxidative Stress Markers of Lipid, Gene, and Protein in Rats
Endemic fluorosis is a systemic chronic disease caused by excessive intake of fluoride. It is widely accepted that oxidative stress is closely related to fluorosis; however, molecular mechanism of oxidative stress in fluorosis remains unclear. This study investigated the effects of fluoride (F) on o...
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| Veröffentlicht in: | Biological trace element research 2021-06, Vol.199 (6), p.2238-2246 |
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| description | Endemic fluorosis is a systemic chronic disease caused by excessive intake of fluoride. It is widely accepted that oxidative stress is closely related to fluorosis; however, molecular mechanism of oxidative stress in fluorosis remains unclear. This study investigated the effects of fluoride (F) on oxidative stress markers of lipid, gene, and protein in rats for revealing molecular mechanism of oxidative stress in fluorosis. The results showed concentration and exposure time of fluoride both had a significant effect on MDA and 8-OHdG. Fluoride concentration significantly impacted AGEs level, but exposure time did not. AOPP was not statistically different among the groups. AGEs decreased with the increase of fluoride in the rats with 3 months of fluoride treatment. The correlation analysis showed the degree of dental fluorosis was significantly negatively correlated with 8-OHdG at 1 month and 3 months, and negatively correlated with AGEs at 3 months. In the rats with 100 mg/L of fluoride treatment, MDA was significant positively correlated with 8-OHdG, and negatively correlated with AGEs. 8-OHdG was significantly negatively correlated with AGEs in the control group and 100 mg/L fluoride group. Taken together, fluoride had different effects on oxidative stress markers of lipid, gene, and protein. Excessive fluoride could increase MDA content, and decrease 8-OHdG and AGEs. These findings suggest that oxidative stress involved in molecular pathogenesis of fluorosis is complicated, and needs to furtherly study in the future. |
| doi_str_mv | 10.1007/s12011-020-02336-z |
| format | Article |
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It is widely accepted that oxidative stress is closely related to fluorosis; however, molecular mechanism of oxidative stress in fluorosis remains unclear. This study investigated the effects of fluoride (F) on oxidative stress markers of lipid, gene, and protein in rats for revealing molecular mechanism of oxidative stress in fluorosis. The results showed concentration and exposure time of fluoride both had a significant effect on MDA and 8-OHdG. Fluoride concentration significantly impacted AGEs level, but exposure time did not. AOPP was not statistically different among the groups. AGEs decreased with the increase of fluoride in the rats with 3 months of fluoride treatment. The correlation analysis showed the degree of dental fluorosis was significantly negatively correlated with 8-OHdG at 1 month and 3 months, and negatively correlated with AGEs at 3 months. In the rats with 100 mg/L of fluoride treatment, MDA was significant positively correlated with 8-OHdG, and negatively correlated with AGEs. 8-OHdG was significantly negatively correlated with AGEs in the control group and 100 mg/L fluoride group. Taken together, fluoride had different effects on oxidative stress markers of lipid, gene, and protein. Excessive fluoride could increase MDA content, and decrease 8-OHdG and AGEs. These findings suggest that oxidative stress involved in molecular pathogenesis of fluorosis is complicated, and needs to furtherly study in the future.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-020-02336-z</identifier><identifier>PMID: 32789643</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>8-Hydroxydeoxyguanosine ; Age ; Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Chronic illnesses ; Correlation analysis ; Dental fluorosis ; Fluoride treatments ; Fluorides ; Fluorosis ; Life Sciences ; Lipids ; Markers ; Nutrition ; Oncology ; Oxidative stress ; Pathogenesis ; Proteins</subject><ispartof>Biological trace element research, 2021-06, Vol.199 (6), p.2238-2246</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-aedbbdd13a3dfc1d90b4a2361ce6bb226cfde2d6a5b36b2060dd3cb6e0816e163</citedby><cites>FETCH-LOGICAL-c375t-aedbbdd13a3dfc1d90b4a2361ce6bb226cfde2d6a5b36b2060dd3cb6e0816e163</cites><orcidid>0000-0002-9469-9566</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12011-020-02336-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12011-020-02336-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32789643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhong, Nan</creatorcontrib><creatorcontrib>Yao, Yingjie</creatorcontrib><creatorcontrib>Ma, Yongzheng</creatorcontrib><creatorcontrib>Meng, Xinyue</creatorcontrib><creatorcontrib>Sowanou, Alphonse</creatorcontrib><creatorcontrib>Pei, Junrui</creatorcontrib><title>Effects of Fluoride on Oxidative Stress Markers of Lipid, Gene, and Protein in Rats</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Endemic fluorosis is a systemic chronic disease caused by excessive intake of fluoride. It is widely accepted that oxidative stress is closely related to fluorosis; however, molecular mechanism of oxidative stress in fluorosis remains unclear. This study investigated the effects of fluoride (F) on oxidative stress markers of lipid, gene, and protein in rats for revealing molecular mechanism of oxidative stress in fluorosis. The results showed concentration and exposure time of fluoride both had a significant effect on MDA and 8-OHdG. Fluoride concentration significantly impacted AGEs level, but exposure time did not. AOPP was not statistically different among the groups. AGEs decreased with the increase of fluoride in the rats with 3 months of fluoride treatment. The correlation analysis showed the degree of dental fluorosis was significantly negatively correlated with 8-OHdG at 1 month and 3 months, and negatively correlated with AGEs at 3 months. In the rats with 100 mg/L of fluoride treatment, MDA was significant positively correlated with 8-OHdG, and negatively correlated with AGEs. 8-OHdG was significantly negatively correlated with AGEs in the control group and 100 mg/L fluoride group. Taken together, fluoride had different effects on oxidative stress markers of lipid, gene, and protein. Excessive fluoride could increase MDA content, and decrease 8-OHdG and AGEs. These findings suggest that oxidative stress involved in molecular pathogenesis of fluorosis is complicated, and needs to furtherly study in the future.</description><subject>8-Hydroxydeoxyguanosine</subject><subject>Age</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Chronic illnesses</subject><subject>Correlation analysis</subject><subject>Dental fluorosis</subject><subject>Fluoride treatments</subject><subject>Fluorides</subject><subject>Fluorosis</subject><subject>Life Sciences</subject><subject>Lipids</subject><subject>Markers</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Oxidative stress</subject><subject>Pathogenesis</subject><subject>Proteins</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kE1LxDAQhoMoun78AQ8S8OLB6kzSptujLO4qrCh-nEPSTKW6265JK-qvN7p-gAchQw555p3Mw9guwhEC5McBBSAmICCWlCp5W2EDzLIigVzAKhsAKpmkxTDdYJshPABgLgq5zjakyIeFSuWA3ZxWFZVd4G3Fx7O-9bUj3jb88qV2pqufid90nkLgF8Y_kv_kpvWidod8Qg0dctM4fuXbjuqGx3NturDN1iozC7TzdW-xu_Hp7egsmV5Ozkcn06SUedYlhpy1zqE00lUlugJsaoRUWJKyVghVVo6EUyazUlkBCpyTpVUEQ1QUV9tiB8vchW-fegqdntehpNnMNNT2QYtUppDlmMqI7v9BH9reN_F3WmSYDnPELI-UWFKlb0PwVOmFr-fGv2oE_aFcL5XrqFx_KtdvsWnvK7q3c3I_Ld-OIyCXQIhPzT3539n_xL4DlBuLnA</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Zhong, Nan</creator><creator>Yao, Yingjie</creator><creator>Ma, Yongzheng</creator><creator>Meng, Xinyue</creator><creator>Sowanou, Alphonse</creator><creator>Pei, Junrui</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9469-9566</orcidid></search><sort><creationdate>20210601</creationdate><title>Effects of Fluoride on Oxidative Stress Markers of Lipid, Gene, and Protein in Rats</title><author>Zhong, Nan ; 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In the rats with 100 mg/L of fluoride treatment, MDA was significant positively correlated with 8-OHdG, and negatively correlated with AGEs. 8-OHdG was significantly negatively correlated with AGEs in the control group and 100 mg/L fluoride group. Taken together, fluoride had different effects on oxidative stress markers of lipid, gene, and protein. Excessive fluoride could increase MDA content, and decrease 8-OHdG and AGEs. These findings suggest that oxidative stress involved in molecular pathogenesis of fluorosis is complicated, and needs to furtherly study in the future.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32789643</pmid><doi>10.1007/s12011-020-02336-z</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-9469-9566</orcidid></addata></record> |
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| subjects | 8-Hydroxydeoxyguanosine Age Biochemistry Biomedical and Life Sciences Biotechnology Chronic illnesses Correlation analysis Dental fluorosis Fluoride treatments Fluorides Fluorosis Life Sciences Lipids Markers Nutrition Oncology Oxidative stress Pathogenesis Proteins |
| title | Effects of Fluoride on Oxidative Stress Markers of Lipid, Gene, and Protein in Rats |
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