Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors

Lysophosphatidylserine (LysoPS), an endogenous ligand of G protein-coupled receptors, consists of l-serine, glycerol, and fatty acid moieties connected by phosphodiester and ester linkages, respectively. An ester linkage of phosphatidylserine can be hydrolyzed at the 1-position or at the 2-position...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-09, Vol.63 (17), p.9990-10029
Hauptverfasser:	Nakamura, Sho, Sayama, Misa, Uwamizu, Akiharu, Jung, Sejin, Ikubo, Masaya, Otani, Yuko, Kano, Kuniyuki, Omi, Jumpei, Inoue, Asuka, Aoki, Junken, Ohwada, Tomohiko
Format:	Artikel
Sprache:	eng
Schlagworte:	HEK293 Cells Humans Isomerism Lysophospholipids - chemical synthesis Lysophospholipids - pharmacology Molecular Conformation Molecular Docking Simulation Purinergic P2 Receptor Agonists - chemical synthesis Purinergic P2 Receptor Agonists - pharmacology Receptors, Lysophospholipid - agonists Receptors, Purinergic P2 - metabolism Structure-Activity Relationship
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