A single nucleotide polymorphism genetic risk score to aid diagnosis of coeliac disease: a pilot study in clinical care

Summary Background Single nucleotide polymorphism–based genetic risk scores (GRS) model genetic risk as a continuum and can discriminate coeliac disease but have not been validated in clinic. Human leukocyte antigen (HLA) DQ gene testing is available in clinic but does not include non‐HLA attributed...

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Veröffentlicht in:	Alimentary pharmacology & therapeutics 2020-10, Vol.52 (7), p.1165-1173
Hauptverfasser:	Sharp, Seth A., Jones, Samuel E., Kimmitt, Robert A., Weedon, Michael N., Halpin, Anne M., Wood, Andrew R., Beaumont, Robin N., King, Seema, Heel, David A., Campbell, Patricia M., Hagopian, William A., Turner, Justine M., Oram, Richard A
Format:	Artikel
Sprache:	eng
Schlagworte:	Biobanks Case-Control Studies Celiac disease Celiac Disease - diagnosis Celiac Disease - epidemiology Celiac Disease - genetics Children Diagnosis Gene polymorphism Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Genotyping Health risk assessment Histocompatibility antigen HLA Humans Pilot Projects Polymorphism Polymorphism, Single Nucleotide Risk Factors Single-nucleotide polymorphism
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