Histopathological evaluation of different regenerative protocols using Chitosan‐based formulations for management of immature non‐vital teeth with apical periodontitis: In vivo study
This study aimed to assess regenerative treatment protocols for maturogenesis of immature teeth with apical periodontitis in dogs. Apical periodontitis was induced in immature premolars of 8 mongrel dogs teeth that were divided into 5 groups; regeneration via blood clotting (REG group); chitosan loa...
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| Veröffentlicht in: | Australian endodontic journal 2020-12, Vol.46 (3), p.405-414 |
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| container_title | Australian endodontic journal |
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| creator | Abbas, Khaled Farouk Tawfik, Hossam Hashem, Ahmed Abdel Rahman Ahmed, Hany Mohamed Aly Abu‐Seida, Ashraf Mohamed Refai, Hanan Mohamed |
| description | This study aimed to assess regenerative treatment protocols for maturogenesis of immature teeth with apical periodontitis in dogs. Apical periodontitis was induced in immature premolars of 8 mongrel dogs teeth that were divided into 5 groups; regeneration via blood clotting (REG group); chitosan loaded with demineralised bone matrix (REG‐CD group); chitosan loaded with dexamethazone corticosteroid (REG‐CC group); and positive and negative control groups. All groups showed comparable apical hard tissue formation and significantly different from the control group. Results also showed decrease in inflammatory tissue reaction, bone resorption and periodontal ligament thickness. Tissue reaction and inflammatory infiltrates were significantly less in REG‐CC group compared to others. Other parameters showed no significant difference. In conclusion, regenerative endodontic techniques using chitosan‐based formulations have the potential to be used as an alternative for root maturation in teeth with apical periodontitis. |
| doi_str_mv | 10.1111/aej.12426 |
| format | Article |
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Apical periodontitis was induced in immature premolars of 8 mongrel dogs teeth that were divided into 5 groups; regeneration via blood clotting (REG group); chitosan loaded with demineralised bone matrix (REG‐CD group); chitosan loaded with dexamethazone corticosteroid (REG‐CC group); and positive and negative control groups. All groups showed comparable apical hard tissue formation and significantly different from the control group. Results also showed decrease in inflammatory tissue reaction, bone resorption and periodontal ligament thickness. Tissue reaction and inflammatory infiltrates were significantly less in REG‐CC group compared to others. Other parameters showed no significant difference. In conclusion, regenerative endodontic techniques using chitosan‐based formulations have the potential to be used as an alternative for root maturation in teeth with apical periodontitis.</description><identifier>ISSN: 1329-1947</identifier><identifier>EISSN: 1747-4477</identifier><identifier>DOI: 10.1111/aej.12426</identifier><identifier>PMID: 32783325</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Animals ; apical periodontitis ; Blood coagulation ; Bone matrix ; Bone resorption ; Chitosan ; Clotting ; Corticosteroids ; Dental Pulp Necrosis ; Dentistry ; Dogs ; Endodontics ; Gum disease ; immature teeth ; Inflammation ; Periapical Periodontitis - drug therapy ; Periodontal ligament ; Periodontitis ; Premolars ; Regeneration ; regenerative endodontic procedures ; Regenerative Endodontics ; Teeth</subject><ispartof>Australian endodontic journal, 2020-12, Vol.46 (3), p.405-414</ispartof><rights>2020 Australian Society of Endodontology Inc</rights><rights>2020 Australian Society of Endodontology Inc.</rights><rights>Copyright © 2020 Australian Society of Endodontology Inc</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2686-68997a74d86d6d23485be2a2fbdae5c97ee333a6f0b9fec8bc48e462b46835bc3</citedby><cites>FETCH-LOGICAL-c2686-68997a74d86d6d23485be2a2fbdae5c97ee333a6f0b9fec8bc48e462b46835bc3</cites><orcidid>0000-0003-0776-9288 ; 0000-0001-5466-2016 ; 0000-0002-1989-2104</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faej.12426$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faej.12426$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32783325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abbas, Khaled Farouk</creatorcontrib><creatorcontrib>Tawfik, Hossam</creatorcontrib><creatorcontrib>Hashem, Ahmed Abdel Rahman</creatorcontrib><creatorcontrib>Ahmed, Hany Mohamed Aly</creatorcontrib><creatorcontrib>Abu‐Seida, Ashraf Mohamed</creatorcontrib><creatorcontrib>Refai, Hanan Mohamed</creatorcontrib><title>Histopathological evaluation of different regenerative protocols using Chitosan‐based formulations for management of immature non‐vital teeth with apical periodontitis: In vivo study</title><title>Australian endodontic journal</title><addtitle>Aust Endod J</addtitle><description>This study aimed to assess regenerative treatment protocols for maturogenesis of immature teeth with apical periodontitis in dogs. Apical periodontitis was induced in immature premolars of 8 mongrel dogs teeth that were divided into 5 groups; regeneration via blood clotting (REG group); chitosan loaded with demineralised bone matrix (REG‐CD group); chitosan loaded with dexamethazone corticosteroid (REG‐CC group); and positive and negative control groups. All groups showed comparable apical hard tissue formation and significantly different from the control group. Results also showed decrease in inflammatory tissue reaction, bone resorption and periodontal ligament thickness. Tissue reaction and inflammatory infiltrates were significantly less in REG‐CC group compared to others. Other parameters showed no significant difference. In conclusion, regenerative endodontic techniques using chitosan‐based formulations have the potential to be used as an alternative for root maturation in teeth with apical periodontitis.</description><subject>Animals</subject><subject>apical periodontitis</subject><subject>Blood coagulation</subject><subject>Bone matrix</subject><subject>Bone resorption</subject><subject>Chitosan</subject><subject>Clotting</subject><subject>Corticosteroids</subject><subject>Dental Pulp Necrosis</subject><subject>Dentistry</subject><subject>Dogs</subject><subject>Endodontics</subject><subject>Gum disease</subject><subject>immature teeth</subject><subject>Inflammation</subject><subject>Periapical Periodontitis - drug therapy</subject><subject>Periodontal ligament</subject><subject>Periodontitis</subject><subject>Premolars</subject><subject>Regeneration</subject><subject>regenerative endodontic procedures</subject><subject>Regenerative Endodontics</subject><subject>Teeth</subject><issn>1329-1947</issn><issn>1747-4477</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctu1DAUhiNERS-w4AWQJTbtIm1iO3bCrhq1tKgSG1hHjnMy45FjB19SzY5H4Hl4HJ6kzkxhgVQvfJE_fz72n2Xvy-KyTO1KwPayxBSzV9lJySnPKeX8dZoT3ORlQ_lxdur9tigwJbx8kx0TzGtCcHWS_b5TPthJhI3Vdq2k0AhmoaMIyhpkB9SrYQAHJiAHazDg0s4MaHI2WGm1R9Ers0arjQrWC_Pn569OeOjRYN0Y9V7jlwUahRFrGBdT0qpxFCE6QMYuZ2YV0s0BIGzQo0qdmPa1TOCU7a0JKij_Cd0bNKvZIh9iv3ubHQ1Ce3j3PJ5l329vvq3u8oevn-9X1w-5xKxmOaubhgtO-5r1rMeE1lUHWOCh6wVUsuEAhBDBhqJrBpB1J2kNlOGOsppUnSRn2fnBm978I4IP7ai8BK2FARt9mz6VYNJQWib043_o1kZnUnWJYk2VtOVCXRwo6az3DoZ2cmoUbteWRbsE2qZA232gif3wbIzdCP0_8m-CCbg6AI9Kw-5lU3t98-WgfAL7W7G4</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Abbas, Khaled Farouk</creator><creator>Tawfik, Hossam</creator><creator>Hashem, Ahmed Abdel Rahman</creator><creator>Ahmed, Hany Mohamed Aly</creator><creator>Abu‐Seida, Ashraf Mohamed</creator><creator>Refai, Hanan Mohamed</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0776-9288</orcidid><orcidid>https://orcid.org/0000-0001-5466-2016</orcidid><orcidid>https://orcid.org/0000-0002-1989-2104</orcidid></search><sort><creationdate>202012</creationdate><title>Histopathological evaluation of different regenerative protocols using Chitosan‐based formulations for management of immature non‐vital teeth with apical periodontitis: In vivo study</title><author>Abbas, Khaled Farouk ; Tawfik, Hossam ; Hashem, Ahmed Abdel Rahman ; Ahmed, Hany Mohamed Aly ; Abu‐Seida, Ashraf Mohamed ; Refai, Hanan Mohamed</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2686-68997a74d86d6d23485be2a2fbdae5c97ee333a6f0b9fec8bc48e462b46835bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>apical periodontitis</topic><topic>Blood coagulation</topic><topic>Bone matrix</topic><topic>Bone resorption</topic><topic>Chitosan</topic><topic>Clotting</topic><topic>Corticosteroids</topic><topic>Dental Pulp Necrosis</topic><topic>Dentistry</topic><topic>Dogs</topic><topic>Endodontics</topic><topic>Gum disease</topic><topic>immature teeth</topic><topic>Inflammation</topic><topic>Periapical Periodontitis - drug therapy</topic><topic>Periodontal ligament</topic><topic>Periodontitis</topic><topic>Premolars</topic><topic>Regeneration</topic><topic>regenerative endodontic procedures</topic><topic>Regenerative Endodontics</topic><topic>Teeth</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abbas, Khaled Farouk</creatorcontrib><creatorcontrib>Tawfik, Hossam</creatorcontrib><creatorcontrib>Hashem, Ahmed Abdel Rahman</creatorcontrib><creatorcontrib>Ahmed, Hany Mohamed Aly</creatorcontrib><creatorcontrib>Abu‐Seida, Ashraf Mohamed</creatorcontrib><creatorcontrib>Refai, Hanan Mohamed</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Australian endodontic journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abbas, Khaled Farouk</au><au>Tawfik, Hossam</au><au>Hashem, Ahmed Abdel Rahman</au><au>Ahmed, Hany Mohamed Aly</au><au>Abu‐Seida, Ashraf Mohamed</au><au>Refai, Hanan Mohamed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histopathological evaluation of different regenerative protocols using Chitosan‐based formulations for management of immature non‐vital teeth with apical periodontitis: In vivo study</atitle><jtitle>Australian endodontic journal</jtitle><addtitle>Aust Endod J</addtitle><date>2020-12</date><risdate>2020</risdate><volume>46</volume><issue>3</issue><spage>405</spage><epage>414</epage><pages>405-414</pages><issn>1329-1947</issn><eissn>1747-4477</eissn><abstract>This study aimed to assess regenerative treatment protocols for maturogenesis of immature teeth with apical periodontitis in dogs. Apical periodontitis was induced in immature premolars of 8 mongrel dogs teeth that were divided into 5 groups; regeneration via blood clotting (REG group); chitosan loaded with demineralised bone matrix (REG‐CD group); chitosan loaded with dexamethazone corticosteroid (REG‐CC group); and positive and negative control groups. All groups showed comparable apical hard tissue formation and significantly different from the control group. Results also showed decrease in inflammatory tissue reaction, bone resorption and periodontal ligament thickness. Tissue reaction and inflammatory infiltrates were significantly less in REG‐CC group compared to others. Other parameters showed no significant difference. In conclusion, regenerative endodontic techniques using chitosan‐based formulations have the potential to be used as an alternative for root maturation in teeth with apical periodontitis.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32783325</pmid><doi>10.1111/aej.12426</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0776-9288</orcidid><orcidid>https://orcid.org/0000-0001-5466-2016</orcidid><orcidid>https://orcid.org/0000-0002-1989-2104</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals apical periodontitis Blood coagulation Bone matrix Bone resorption Chitosan Clotting Corticosteroids Dental Pulp Necrosis Dentistry Dogs Endodontics Gum disease immature teeth Inflammation Periapical Periodontitis - drug therapy Periodontal ligament Periodontitis Premolars Regeneration regenerative endodontic procedures Regenerative Endodontics Teeth |
| title | Histopathological evaluation of different regenerative protocols using Chitosan‐based formulations for management of immature non‐vital teeth with apical periodontitis: In vivo study |
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