Schwann cell-specific Pten inactivation reveals essential role of the sympathetic nervous system activity in adipose tissue development

There is increasing evidence that the sympathetic nervous system (SNS) plays an important role in adipose tissue development. However, the underlying molecular mechanism(s) associated with this remains unclear. SNS innervation of white adipose tissue (WAT) is believed to be necessary and sufficient...

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Veröffentlicht in:	Biochemical and biophysical research communications 2020-10, Vol.531 (2), p.118-124
Hauptverfasser:	Li, Xiao-Xiao, Zhang, Shi-Jie, Man, Ka-Yi, Chiu, Amy P., Lo, Lilian H., To, Jeffrey C., Chiu, Cynthia H., Chan, Chi-On, Mok, Daniel K.W., Rowlands, Dewi K., Keng, Vincent W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - cytology Adipocytes - metabolism Adipose Tissue, White - growth & development Adiposity Animals Cell Size Inguinal Canal - anatomy & histology Mice Neurotransmitter Agents - metabolism Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Pten PTEN Phosphohydrolase - metabolism Pyrimidines - pharmacology Pyrroles - pharmacology Schwann cell Schwann Cells - metabolism Sympathetic nervous system Sympathetic Nervous System - metabolism Up-Regulation White adipose tissue Wnt Signaling Pathway
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