Newborn BCG vaccination complemented by boosting correlates better with reduced juvenile diabetes in females, than vaccination alone

•Retrospective birth cohorts and national vaccination history show BCG effect on T1D.•Newborn BCG vaccination and boosting prevents T1D in female but not in male youth.•BCG mitigates murine and human T1D glycaemia by induction of aerobic glycolysis.•BCG prevents T1D in female NOD mice by suppression...

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Veröffentlicht in:	Vaccine 2020-09, Vol.38 (41), p.6427-6434
1. Verfasser:	Klein, Benjamin Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age Animal models Animals Autoimmune diseases Bacillus Bacillus Calmette-Guerin vaccine BCG BCG Vaccine Birth Birth-cohorts Births Child Datasets Diabetes Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 Epidemiology Female Females Glucose Humans Hygiene Hypotheses Infant, Newborn Microorganisms Modernization Neonates Newborns Population growth Retrospective Studies Schedules Statistical analysis Trends Tuberculosis Type 1 diabetes Urbanization Vaccination Vaccines
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