N-Cyclohexylimidazo[1,2-a]pyridine derivatives as multi-target-directed ligands for treatment of Alzheimer's disease

[Display omitted] •A series of N-Cyclohexylimidazo[1,2-a]pyridine derivatives were designed and synthesized.•Compound 7g displayed excellent BACE1 inhibitory activity (IC50 = 8.9 µM).•Compounds 7g and 7h showed selective butyrylcholinesterase inhibitory action at IC50 values of 3.2 and 2.5 µM, respe...

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Veröffentlicht in:	Bioorganic chemistry 2020-10, Vol.103, p.104146-104146, Article 104146
Hauptverfasser:	Haghighijoo, Zahra, Akrami, Sara, Saeedi, Mina, Zonouzi, Afsaneh, Iraji, Aida, Larijani, Bagher, Fakherzadeh, Hossein, Sharifi, Farshad, Arzaghi, Seyed Masoud, Mahdavi, Mohammad, Edraki, Najmeh
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2,3-triazole Alzheimer Disease - drug therapy Antioxidant activity Antioxidants - pharmacology Antioxidants - therapeutic use BACE1 inhibitor Cholinesterase inhibitor Humans Imidazopyridine Ligands Molecular Docking Simulation - methods Molecular Structure Neurodegenerative disorder Pyridines - pharmacology Pyridines - therapeutic use Structure-Activity Relationship
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