The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer
The purpose of this study is to assess accelerator-based boron neutron capture reaction (BNCR) in human tumor cell lines by colony formation assay and modified high density survival assay (HDS assay). The results of post irradiation survival rate in human oral squamous cell carcinoma and osteosarcom...
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| Veröffentlicht in: | Applied radiation and isotopes 2020-11, Vol.165, p.109271-109271, Article 109271 |
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| container_title | Applied radiation and isotopes |
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| creator | Wang, Shou Igawa, Kazuyo Ogawara, Ryo Suda, Mitsuru Hamano, Tsuyoshi Ibaragi, Soichiro Hanafusa, Tadashi Ichikawa, Yasuaki Sasaki, Akira |
| description | The purpose of this study is to assess accelerator-based boron neutron capture reaction (BNCR) in human tumor cell lines by colony formation assay and modified high density survival assay (HDS assay). The results of post irradiation survival rate in human oral squamous cell carcinoma and osteosarcoma using both assays were similar. Therefore, HDS assay would be efficient to evaluate BNCR in not only tumor cells but also in normal cells as BNCT screening.
•10B uptake was similar in osteosarcoma and squamous cell carcinoma cells.•Colony formation and modified high-density survival assays showed the similar data.•The efficacy of boron neutron capture reaction in osteosarcoma cells was confirmed. |
| doi_str_mv | 10.1016/j.apradiso.2020.109271 |
| format | Article |
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•10B uptake was similar in osteosarcoma and squamous cell carcinoma cells.•Colony formation and modified high-density survival assays showed the similar data.•The efficacy of boron neutron capture reaction in osteosarcoma cells was confirmed.</description><identifier>ISSN: 0969-8043</identifier><identifier>EISSN: 1872-9800</identifier><identifier>DOI: 10.1016/j.apradiso.2020.109271</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>BNCR ; BPA ; Head and neck cancer ; Osteosarcoma ; SCC</subject><ispartof>Applied radiation and isotopes, 2020-11, Vol.165, p.109271-109271, Article 109271</ispartof><rights>2020 Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c444t-b776e4b0b103cad8b9e33c611887f60107dfc7063d6cce40dd52d793cc36eda03</citedby><cites>FETCH-LOGICAL-c444t-b776e4b0b103cad8b9e33c611887f60107dfc7063d6cce40dd52d793cc36eda03</cites><orcidid>0000-0003-4016-8441</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.apradiso.2020.109271$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Wang, Shou</creatorcontrib><creatorcontrib>Igawa, Kazuyo</creatorcontrib><creatorcontrib>Ogawara, Ryo</creatorcontrib><creatorcontrib>Suda, Mitsuru</creatorcontrib><creatorcontrib>Hamano, Tsuyoshi</creatorcontrib><creatorcontrib>Ibaragi, Soichiro</creatorcontrib><creatorcontrib>Hanafusa, Tadashi</creatorcontrib><creatorcontrib>Ichikawa, Yasuaki</creatorcontrib><creatorcontrib>Sasaki, Akira</creatorcontrib><title>The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer</title><title>Applied radiation and isotopes</title><description>The purpose of this study is to assess accelerator-based boron neutron capture reaction (BNCR) in human tumor cell lines by colony formation assay and modified high density survival assay (HDS assay). The results of post irradiation survival rate in human oral squamous cell carcinoma and osteosarcoma using both assays were similar. Therefore, HDS assay would be efficient to evaluate BNCR in not only tumor cells but also in normal cells as BNCT screening.
•10B uptake was similar in osteosarcoma and squamous cell carcinoma cells.•Colony formation and modified high-density survival assays showed the similar data.•The efficacy of boron neutron capture reaction in osteosarcoma cells was confirmed.</description><subject>BNCR</subject><subject>BPA</subject><subject>Head and neck cancer</subject><subject>Osteosarcoma</subject><subject>SCC</subject><issn>0969-8043</issn><issn>1872-9800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFUF1LwzAUDaLgnP4F6aMvnTdNTZo3ZfgFA1_mc0iTW5bZNTVpB_v3pps-CxfO5XDO5Z5DyC2FBQXK77cL3QdtXfSLAoqJlIWgZ2RGK1HksgI4JzOQXOYVlOySXMW4BYCyksWMqPUGM20Mthj04ENe64g2q33wXdbhOExodD-MAbOA2gwuEbjX7aiPazzEAXdZ40O2QW0z3dnkM1_J1BkM1-Si0W3Em1-ck8-X5_XyLV99vL4vn1a5KctyyGshOJY11BSY0baqJTJmOKVVJRoOFIRtjADOLE-_lmDtQ2GFZMYwjlYDm5O7090--O8R46B2LqZUre7Qj1EVJTuOFEnKT1ITfIwBG9UHt9PhoCioqVG1VX-NqqlRdWo0GR9PRkxB9g6DisZhSmldQDMo691_J34AdwaEEg</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Wang, Shou</creator><creator>Igawa, Kazuyo</creator><creator>Ogawara, Ryo</creator><creator>Suda, Mitsuru</creator><creator>Hamano, Tsuyoshi</creator><creator>Ibaragi, Soichiro</creator><creator>Hanafusa, Tadashi</creator><creator>Ichikawa, Yasuaki</creator><creator>Sasaki, Akira</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4016-8441</orcidid></search><sort><creationdate>20201101</creationdate><title>The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer</title><author>Wang, Shou ; Igawa, Kazuyo ; Ogawara, Ryo ; Suda, Mitsuru ; Hamano, Tsuyoshi ; Ibaragi, Soichiro ; Hanafusa, Tadashi ; Ichikawa, Yasuaki ; Sasaki, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c444t-b776e4b0b103cad8b9e33c611887f60107dfc7063d6cce40dd52d793cc36eda03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>BNCR</topic><topic>BPA</topic><topic>Head and neck cancer</topic><topic>Osteosarcoma</topic><topic>SCC</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shou</creatorcontrib><creatorcontrib>Igawa, Kazuyo</creatorcontrib><creatorcontrib>Ogawara, Ryo</creatorcontrib><creatorcontrib>Suda, Mitsuru</creatorcontrib><creatorcontrib>Hamano, Tsuyoshi</creatorcontrib><creatorcontrib>Ibaragi, Soichiro</creatorcontrib><creatorcontrib>Hanafusa, Tadashi</creatorcontrib><creatorcontrib>Ichikawa, Yasuaki</creatorcontrib><creatorcontrib>Sasaki, Akira</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Applied radiation and isotopes</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shou</au><au>Igawa, Kazuyo</au><au>Ogawara, Ryo</au><au>Suda, Mitsuru</au><au>Hamano, Tsuyoshi</au><au>Ibaragi, Soichiro</au><au>Hanafusa, Tadashi</au><au>Ichikawa, Yasuaki</au><au>Sasaki, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer</atitle><jtitle>Applied radiation and isotopes</jtitle><date>2020-11-01</date><risdate>2020</risdate><volume>165</volume><spage>109271</spage><epage>109271</epage><pages>109271-109271</pages><artnum>109271</artnum><issn>0969-8043</issn><eissn>1872-9800</eissn><abstract>The purpose of this study is to assess accelerator-based boron neutron capture reaction (BNCR) in human tumor cell lines by colony formation assay and modified high density survival assay (HDS assay). The results of post irradiation survival rate in human oral squamous cell carcinoma and osteosarcoma using both assays were similar. Therefore, HDS assay would be efficient to evaluate BNCR in not only tumor cells but also in normal cells as BNCT screening.
•10B uptake was similar in osteosarcoma and squamous cell carcinoma cells.•Colony formation and modified high-density survival assays showed the similar data.•The efficacy of boron neutron capture reaction in osteosarcoma cells was confirmed.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.apradiso.2020.109271</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-4016-8441</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | BNCR BPA Head and neck cancer Osteosarcoma SCC |
| title | The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer |
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