The accelerator-based boron neutron capture reaction evaluation system for head and neck cancer

The purpose of this study is to assess accelerator-based boron neutron capture reaction (BNCR) in human tumor cell lines by colony formation assay and modified high density survival assay (HDS assay). The results of post irradiation survival rate in human oral squamous cell carcinoma and osteosarcoma using both assays were similar. Therefore, HDS assay would be efficient to evaluate BNCR in not only tumor cells but also in normal cells as BNCT screening. •10B uptake was similar in osteosarcoma and squamous cell carcinoma cells.•Colony formation and modified high-density survival assays showed the similar data.•The efficacy of boron neutron capture reaction in osteosarcoma cells was confirmed.